[1]蒋峰丽,马亚楠,乌 丽.胎盘生长因子在子痫前期早期诊断中的临床价值[J].医学信息,2019,32(16):160-162.[doi:10.3969/j.issn.1006-1959.2019.16.054]
　JIANG Feng-li,MA Ya-nan,WU Li.Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia[J].Journal of Medical Information,2019,32(16):160-162.[doi:10.3969/j.issn.1006-1959.2019.16.054]
点击复制

胎盘生长因子在子痫前期早期诊断中的临床价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
160-162
栏目:
诊疗技术
出版日期:
2019-08-15

文章信息/Info

Title:
Clinical Value of Placental Growth Factor in Early Diagnosis of Preeclampsia
文章编号:
1006-1959（2019）16-0160-03
作者:
蒋峰丽1; 马亚楠2; 乌 丽1
1.中国医学科学院整形外科医院检验科，北京 100043； 2.天津市第三中心医院检验科，天津 300170
Author(s):
JIANG Feng-li1; MA Ya-nan2; WU Li1
1.Department of Clinical Laboratory,Chinese Academy of Medical Sciences Plastic Surgery Hospital,Beijing 100043,China; 2.Department of Clinical Laboratory,Tianjin Third Central Hospital,Tianjin 300170,China
关键词:
子痫前期; 胎盘生长因子; 灵敏度; 特异度
Keywords:
Key words：Preeclampsia; Placental growth factor; Sensitivity; Specificity
分类号:
R714.24+4
DOI:
10.3969/j.issn.1006-1959.2019.16.054
文献标志码:
A
摘要:
目的 探讨外周血浆中胎盘生长因子（PLGF）对子痫前期（PE）患者的早期预测意义。方法 选取天津市第三中心医院收治的105例正常妊娠妇女（对照组）、69例轻度PE患者（轻度组）及54例重度PE患者（重度组）为研究对象，采用荧光免疫分方法测定血浆中PLGF的浓度。使用ROC曲线分析PLGF，预测PE发生的灵敏度和特异度。结果 重度组患者血清PIGF水平低于轻度组和对照组，且轻度组低于对照组，差异均有统计学意义（P＜0.05）。ROC曲线分析显示，血清PIGF水平在预测PE发生中，曲线下面积0.962（95%CI：0.921~1.000，P＜0.05），取截点值47.5 pg/ml，特异度为0.907，敏感度为0.900。结论 PE患者外周血PLGF水平明显降低，PLGF水平与疾病严重程度呈负相关，PLGF或许可以作为早期筛选PE患者的方法之一，预防和控制PE，为母婴安全提供帮助。
Abstract:
Abstract：Objective To investigate the early predictive value of placental plasma growth factor (PLGF) in patients with preeclampsia (PE).Methods A total of 105 normal pregnant women (control group), 69 patients with mild PE (mild group) and 54 patients with severe PE (severe group) were enrolled in the Third Central Hospital of Tianjin. The concentration of PLGF in plasma was measured. The PLGF was analyzed using the ROC curve to predict the sensitivity and specificity of PE occurrence.Results Serum PIGF levels in the severe group were lower than those in the mild group and the control group, and the mild group was lower than the control group, the difference was statistically significant (P<0.05). ROC curve analysis showed that serum PIGF level in the prediction of PE occurred, the area under the curve was 0.962 (95% CI: 0.921~1.000, P<0.05), the cut-off point value was 47.5 pg/ml, the specificity was 0.907, and the sensitivity was 0.900.Conclusion The level of PLGF in peripheral blood of PE patients is significantly decreased. The level of PLGF is negatively correlated with the severity of disease. PLGF may be one of the methods for early screening of PE patients to prevent and control PE and provide help for maternal and child safety.

参考文献/References:

[1]Taraseviciene V,Grybauskiene R,Maciuleviciene R.sFlt-1,PlGF,sFlt-1/PlGF ratio and uterine artery Doppler for preeclampsia diagnostics[J].Medicina,2016,52(6):349-353. [2]Klein E,Schlembach D,Ramoni A,et al.Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia[J].PLoS One,2016,11(5):e0156013. [3]王珊,张燕,钟文明,等.子痫前期发病的相关高危因素调查分析[J].中国妇幼保健,2017,32(1):125-127. [4]果崇慧,杨青,赵雪莲,等.子痫前期相关危险因素的临床分析[J].河北医药,2016,38(16):2465-2467. [5]Verlohren S,Galindo A,Schlembach D,et al.An automated method for the determination of the sFlt-1/PlGF ratio in the assessment of preeclampsia[J].Am J Obstet Gynecol,2010,202(2):161.e1-161.e11. [6]Duhig KE,Shennan AH.Recent advances in the diagnosis and management of pre-eclampsia[J].F1000Prime Rep,2015(7):242. [7]Hayes E,Dominguez C,VoelkelS,et al.Effect of glycodelin on the production of vascular endothelial growth factor in cumulus cells[J].Ferrtil Steril,2013,85(5):1553-1556. [8]Karumanchi SA,Granger JP.Preeclampsia and pregnancy-related hypertensive disorders[J].Hypertension,2016,67(2):238-242. [9]Mijal RS,Holzman CB,Rana S,et al.Mid-regnancy levels of angiogenic markers as indicators of pathways to preterm delivery[J].Matern Fetal Neonatal Med,2012,25(7):1135-1141. [10]谢幸,苟文丽.妇产科学[M].第8版.北京:人民卫生出版社,2013. [11]Tang P,Xu J,Xie BJ,et al.Use of serum and urinary soluble Flt-1 and PLGF in the diagnosis of preeclampsia[J].Hypertens Pregnancy,2017,36(1):48-52. [12]Stepan H, Herraiz I,Schlembach D,et al.Implementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy:implications for clinical practice[J].Ultrasound Obstet Gynecol,2015,45(3):241-246. [13]Taylor RN,Grimwood J,Taylor R,et al.Longicaudate serum concentrations of placental growth factor: evidence for abnormalplacental angiogenesis in pathologic pregnancies[J].Am J Obstet Gyne,2003,188(1):177. [14]贾冬丽,方丽丽,司晓辉.血清血小板衍生生长因子-B、胎盘生长因子和可溶性Fms样酪氨酸激酶1水平检测在预测子痫前期发生中的意义[J].安徽医药,2018,22(4):685-688. [15]陈雪,应豪,杨慧琳,等.血清PAPP-A、PIGF和sFlt-1在子痫前期患者中的表达及意义[J].医学临床研究,2015,32(7):1277-1279. [16]苏晓珠.重度子痫前期162例并发症的研究[J].齐齐哈尔医学院学报,2014,35(1):89-90. [17]Rohra DK,Zeb A,Qureishi RN,et al.Prediction of preeclampsia during early pregnancy in primiparas with soluble fms-like tyrosine kinase-1 and placental growth factor[J].Natl Med J India,2012,25(2):68-73. [18]Mijal RS,Holzman CB,Rana S,et al.Mid-pregnancy levels of angiogenic markers as indicators of pathways to preterm delivery[J].J Matern Fetal Neonatal Med,2012,25(7):1135-1141. [19]Kolialexi A,Mavreli D,Papantoniou N.Proteomics for early prenatal screening of pregnancy complications:a 2017 perspective[J].Expert Rev Proteomics,2017,14(2):113-115. [20]吴雪琴,赵勇,朱小芳,等.子痫前期患者白细胞介素-8和胎盘生长因子的表达及其意义[J].热带医学杂志,2009,9(5):539-541. [21]黄凤凤,张东妹.孕妇血清sEng、sFlt-1及PLGF浓度变化对子痫前期的预测价值[J].广东医学,2015,36(4):597-598. [22]Arakaki T,Hasegawa J,Nakamura M,et al.Prediction of early-andlate-onset pregnancy-induced hypertension using placental volume on three-dimensional ultrasound and uterine artery Doppler[J].Ultrasound in Obstetrics&Gynecology,2015,45(5):539-543. [23]Momen A,Pedro M,Navid S,et al.Ultrasound-guided three-dimensional needle steering in biological tissue with curved surfaces[J].Medical Engineering&Physics,2015,37(1):145-150.

相似文献/References:

[1]李仲均,黄丽姗,曾带娣,等.孕妇血清维生素A、维生素E、25-羟基维生素D与 子痫前期的相关性研究[J].医学信息,2019,32(11):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
　LI Zhong-jun,HUANG Li-shan,ZENG Dai-di,et al.Correlation between Serum Vitamin A,Vitamin E,25-hydroxyvitamin D and Pre-eclampsia in Pregnant Women[J].Journal of Medical Information,2019,32(16):63.[doi:10.3969/j.issn.1006-1959.2019.11.018]
[2]尤 鑫,崔洪艳.PDGF与子痫前期相关性的研究进展[J].医学信息,2019,32(17):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
　YOU Xin,CUI Hong-yan.Advances in Research on the Relationship between PDGF and Preeclampsia[J].Journal of Medical Information,2019,32(16):53.[doi:10.3969/j.issn.1006-1959.2019.17.017]
[3]王金凤,王克涛.红细胞压积、血清纤维蛋白原、D-二聚体及尿白蛋白/尿肌酐比值在子痫前期诊断中的价值[J].医学信息,2020,33(20):156.[doi:10.3969/j.issn.1006-1959.2020.20.049]
　WANG Jin-feng,WANG Ke-tao.The Value of Hematocrit,Serum Fibrinogen,D-dimer and Urine Albumin/Urinary Creatinine Ratio in the Diagnosis of Preeclampsia[J].Journal of Medical Information,2020,33(16):156.[doi:10.3969/j.issn.1006-1959.2020.20.049]
[4]史爱红,刘爱玲,封 玲,等.凝血功能指标对不同类型子痫前期的诊断价值[J].医学信息,2020,33(21):90.[doi:10.3969/j.issn.1006-1959.2020.21.026]
　SHI Ai-hong,LIU Ai-ling,FENG Ling,et al.The Diagnostic Value of Coagulation Function Indexes for Different Types of Preeclampsia[J].Journal of Medical Information,2020,33(16):90.[doi:10.3969/j.issn.1006-1959.2020.21.026]
[5]杨双燕,杨琦芳,李银凤.子痫前期病因及发病机制的研究[J].医学信息,2021,34(04):52.[doi:10.3969/j.issn.1006-1959.2021.04.014]
　YANG Shuang-yan,YANG Qi-fang,LI Yin-feng.Study on the Etiology and Pathogenesis of Preeclampsia[J].Journal of Medical Information,2021,34(16):52.[doi:10.3969/j.issn.1006-1959.2021.04.014]
[6]车 莹,杨 丽,孙 昊.前瞻性护理对妊娠高血压轻度子痫前期患者血压及自我管理能力的影响[J].医学信息,2022,35(02):190.[doi:10.3969/j.issn.1006-1959.2022.02.051]
　CHE Ying,YANG Li,SUN Hao.Effect of Prospective Nursing on Blood Pressure and Self-management Ability of Patientswith Mild Preeclampsia of Pregnancy-induced Hypertension[J].Journal of Medical Information,2022,35(16):190.[doi:10.3969/j.issn.1006-1959.2022.02.051]
[7]马梦茹,吴胜军,赵宗霞,等.子痫前期患者相关生化指标的研究进展[J].医学信息,2022,35(22):176.[doi:10.3969/j.issn.1006-1959.2022.22.043]
　MA Meng-ru,WU Sheng-jun,ZHAO Zong-xia,et al.Research Progress of Biochemical Indexes in Patients with Preeclampsia[J].Journal of Medical Information,2022,35(16):176.[doi:10.3969/j.issn.1006-1959.2022.22.043]
[8]霍春霞,谢 玲,张爱萍.早期干预治疗对早期筛查阳性子痫前期孕妇妊娠结局的影响[J].医学信息,2023,36(19):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]
　HUO Chun-xia,XIE Ling,ZHANG Ai-ping.Effect of Early Intervention on Pregnancy Outcome of Pregnant Women with Early Screening Positive Preeclampsia[J].Journal of Medical Information,2023,36(16):134.[doi:10.3969/j.issn.1006-1959.2023.19.029]
[9]郭 丽,黄淑娟,隋红梅.子痫前期的药物预防研究[J].医学信息,2023,36(23):170.[doi:10.3969/j.issn.1006-1959.2023.23.043]
　GUO Li,HUANG Shu-juan,SUI Hong-mei.Research on Drug Prevention of Preeclampsia[J].Journal of Medical Information,2023,36(16):170.[doi:10.3969/j.issn.1006-1959.2023.23.043]
[10]李 琳,李仲均.普伐他汀的作用机制及防治子痫前期的研究[J].医学信息,2024,37(05):178.[doi:10.3969/j.issn.1006-1959.2024.05.034]
　LI Lin,LI Zhong-jun.Study on the Mechanism of Pravastatin and its Prevention and Treatment of Preeclampsia[J].Journal of Medical Information,2024,37(16):178.[doi:10.3969/j.issn.1006-1959.2024.05.034]

更新日期/Last Update: 2019-08-15