[1]谢春燕.化学发光免疫分析法在甲状腺疾病诊断中的应用[J].医学信息,2019,32(16):169-171.[doi:10.3969/j.issn.1006-1959.2019.16.058]
　XIE Chun-yan.Application of Chemiluminescence Immunoassay in the Diagnosis of Thyroid Diseases[J].Journal of Medical Information,2019,32(16):169-171.[doi:10.3969/j.issn.1006-1959.2019.16.058]
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化学发光免疫分析法在甲状腺疾病诊断中的应用()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
169-171
栏目:
诊疗技术
出版日期:
2019-08-15

文章信息/Info

Title:
Application of Chemiluminescence Immunoassay in the Diagnosis of Thyroid Diseases
文章编号:
1006-1959（2019）16-0169-03
作者:
谢春燕
重庆市九龙坡区中西医结合医院检验科，重庆 401326
Author(s):
XIE Chun-yan
Department of Clinical Laboratory,Chongqing Jiulongpo District Hospital of Integrated Traditional Chinese and Western Medicine,Chongqing 401326,China
关键词:
化学发光免疫分析法; 甲状腺疾病; 甲状腺球蛋白水平; 甲状腺肿瘤; 甲状腺功能亢进
Keywords:
Key words： Chemiluminescence immunoassay; Thyroid disease; Thyroglobulin level; Thyroid neoplasms;  Hyperthyroidism
分类号:
R446.6
DOI:
10.3969/j.issn.1006-1959.2019.16.058
文献标志码:
A
摘要:
目的 探讨化学发光免疫分析法在甲状腺疾病诊断中的应用。方法 选取2017年5月~2018年5月我院接收的甲状腺疾病患者63例作为研究对象，按照疾病类型分为实验1组（甲状腺肿瘤患者）、实验2组（甲状腺功能亢进患者）、实验3组（其他甲状腺疾病患者），每组21例；另选取同期来我院健康体检人员21名作为对照组。所有研究对象均实施化学发光免疫分析法、放射免疫法评估甲状腺球蛋白水平、假阴性、假阳性及符合率、敏感度、特异度。结果 实验1、2、3组甲状腺球蛋白水平高于对照组，四组放射免疫法检测的甲状腺球蛋白低于化学发光免疫法，差异有统计学意义（P＜0.05）。四组假阴性、假阳性、符合率、敏感度、特异度比较，差异无统计学意义（P＞0.05）；化学发光免疫法检测结果优于放射免疫法，差异有统计学意义（P＜0.05）。结论 在甲状腺疾病临床检验中，化学发光免疫分析法比放射免疫法更具有优势，其操作简单，且对甲状腺疾病有极高的敏感度、特异度。
Abstract:
Abstract：Objective To investigate the application of chemiluminescence immunoassay in the diagnosis of thyroid diseases. Methods 63 patients with thyroid disease admitted to our hospital from May 2017 to May 2018 were selected as subjects. According to the type of disease, they were divided into experimental group 1 (thyroid tumor patients), experimental group 2 (thyroid hyperthyroidism patients), and experiment group 3 (other patients with thyroid disease), 21 cases in each group; another 21 healthy people in our hospital were selected as the control group. All subjects were subjected to chemiluminescence immunoassay and radioimmunoassay to assess thyroglobulin levels, false negatives, false positives and coincidence rates, sensitivity, and specificity.Results The levels of thyroglobulin in groups 1, 2 and 3 were higher than those in the control group. The thyroglobulin detected by radioimmunoassay was lower than that in chemiluminescence immunoassay,the difference was statistically significant (P<0.05). There were no significant differences in the four groups of false negative, false positive, coincidence rate, sensitivity and specificity (P>0.05). The results of chemiluminescence immunoassay were better than radioimmunoassay,the difference was statistically significant (P<0.05).Conclusion In the clinical test of thyroid disease, chemiluminescence immunoassay has more advantages than radioimmunoassay, its operation is simple, and it has extremely high sensitivity and specificity to thyroid diseases.

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更新日期/Last Update: 2019-08-15