[1]林飞帆,石学军,王春光.替吉奥对比卡培他滨在晚期乳腺癌疗效及安全性的Meta分析[J].医学信息,2019,32(10):91-94.[doi:10.3969/j.issn.1006-1959.2019.10.029]
　LIN Fei-fan,SHI Xue-jun,WANG Chun-guang.Meta-analysis of the Efficacy and Safety of Tiggio Versus Capecitabine in Advanced Breast Cancer[J].Journal of Medical Information,2019,32(10):91-94.[doi:10.3969/j.issn.1006-1959.2019.10.029]
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替吉奥对比卡培他滨在晚期乳腺癌疗效及安全性的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年10期
页码:
91-94
栏目:
论著
出版日期:
2019-05-15

文章信息/Info

Title:
Meta-analysis of the Efficacy and Safety of Tiggio Versus Capecitabine in Advanced Breast Cancer
文章编号:
1006-1959（2019）10-0091-04
作者:
林飞帆; 石学军; 王春光
（重庆医科大学附属永川医院肿瘤内科，重庆 402160）
Author(s):
LIN Fei-fan; SHI Xue-jun; WANG Chun-guang
(Department of Oncology,Yongchuan Hospital Affiliated to Chongqing Medical University, Chongqing 402160,China)
关键词:
替吉奥; 卡培他; 晚期乳腺癌; Meta分析
Keywords:
Tiggio; Capecita; Advanced breast cancer; Meta-analysis
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2019.10.029
文献标志码:
A
摘要:
目的 对替吉奥与卡培他滨在晚期乳腺癌的疗效及安全性进行Meta分析。方法 计算机检索Pubmed、The Cochrane Library、EMbase、CKNI、万方数据库，按照纳入和排除标准筛选文献和提取资料后，采用 RevMan 5.3 软件进行Meta分析。结果 最终纳入12篇文献，包括829例患者。Meta分析结果显示，替吉奥较卡培他滨能有效改善晚期乳腺癌疾病控制率，差异有统计学意义[OR=1.64（1.12，2.40），P=0.01]；而二者客观缓解率比较，差异无统计学意义[OR=1.34（0.99，1.81），P=0.05]；安全性方面：替吉奥在恶性呕吐[OR=0.32（0.16，0.65），P=0.002]、手足综合症[OR=0.14（0.06，0.30），P＜0.00001]发生率低于卡培他滨，差异有统计学意义。结论 在治疗晚期乳腺癌方面，替吉奥与卡培他滨相比能有效改善疾病控制率，在恶性呕吐及手足综合症方面具有更良好的安全性。
Abstract:
Objective To conduct a meta-analysis of the efficacy and safety of Tiggio and capecitabine in advanced breast cancer. Methods The Pubmed, The Cochrane Library, EMbase, CKNI, and Wanfang databases were searched by computer. After screening and extracting data according to inclusion and exclusion criteria, meta-analysis was performed using RevMan 5.3 software. Results A total of 12 articles were included, including 829 patients. Meta-analysis showed that Tiggio was more effective than capecitabine in improving the control rate of advanced breast cancer, and the difference was statistically significant [OR=1.64 (1.12, 2.40), P=0.01]; The difference was not statistically significant [OR=1.34 (0.99, 1.81), P=0.05]; safety: Tiggio in malignant vomiting [OR=0.32 (0.16, 0.65), P=0.002], hand-foot syndrome [ The incidence of OR=0.14 (0.06, 0.30), P<0.00001] was lower than that of capecitabine, and the difference was statistically significant. Conclusion In the treatment of advanced breast cancer, tiggio can effectively improve the disease control rate compared with capecitabine, and has better safety in malignant vomiting and hand-foot syndrome.

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更新日期/Last Update: 2019-05-15