[1]钱晓娟,熊华珍,袁雯婷,等.NT-proBNP对短暂性脑缺血发作患者近期脑卒中风险的预测价值[J].医学信息,2019,32(24):47-49.[doi:10.3969/j.issn.1006-1959.2019.24.015]
　QIAN Xiao-juan,XIONG Hua-zhen,YUAN Wen-ting,et al.Predictive Value of NT-proBNP in the Risk of Stroke in Patients with Transient Ischemic Attack[J].Medical Information,2019,32(24):47-49.[doi:10.3969/j.issn.1006-1959.2019.24.015]
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NT-proBNP对短暂性脑缺血发作患者近期脑卒中风险的预测价值()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年24期
页码:
47-49
栏目:
论著
出版日期:
2019-12-15

文章信息/Info

Title:
Predictive Value of NT-proBNP in the Risk of Stroke in Patients with Transient Ischemic Attack
文章编号:
1006-1959（2019）24-0047-03
作者:
钱晓娟; 熊华珍; 袁雯婷; 周 茹
（湖北黄梅县人民医院检验科，湖北 黄梅 435500）
Author(s):
QIAN Xiao-juan; XIONG Hua-zhen; YUAN Wen-ting; ZHOU Ru
(Department of Laboratory Medicine,Huangmei County People’s Hospital,Huangmei 435500,Hubei,China)
关键词:
N末端B型利钠肽; 短暂性脑缺血发作; 脑卒中; 预测价值
Keywords:
N-terminal B-type natriuretic peptide; Transient ischemic attack; Stroke; Predictive value
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.24.015
文献标志码:
A
摘要:
目的 探讨血清N末端B型利钠肽（NT-proBNP）对短暂性脑缺血发作（TIA）患者近期脑卒中风险的预测价值。方法 回顾性分析2017年2月~2019年5月我院118例确诊为TIA患者的临床资料，将70例1个月内未发生脑卒中者作为对照组，48例发生卒中者作为观察组，按美国国立卫生研究院卒中量表（NIHSS）分为轻度卒中组18例、中度卒中组16例、重度卒中组14例，分析TIA患者发生近期脑卒中的相关影响因素，比较四组NT-proBNP水平。结果 观察组与对照组单侧肢体无力比较，差异无统计学意义（P＞0.05）；两组同侧颈动脉狭窄≥50%、存在DWI高信号、症状持续时间≥10 min比较，差异有统计学意义（P＜0.05）。多因素Logistic回归分析显示，同侧颈动脉狭窄≥50%、存在DWI高信号、症状持续时间≥10 min是TIA患者发生近期脑卒中的独立影响因素（P＜0.05）。轻度、中度、重度脑卒中组NT-proBNP水平高于对照组（P＜0.05）；且随着脑卒中严重程度的加深，NT-proBNP水平不断提升，其中为轻度脑卒中组＜中度脑卒中组＜重度脑卒中组，差异有统计学意义（P＜0.05）。ROC曲线分析显示，NT-proBNP水平对TIA患者近期脑卒中风险预测的曲线下面积分别为0.863、0.905、0.927。结论 短暂性脑缺血脑卒中患者血清NT-proBNP水平随卒中程度的加深而升高，NT-proBNP水平可作为临床预测TIA患者发展为脑卒中的有效指标。
Abstract:
Objective To investigate the predictive value of serum N-terminal B-type natriuretic peptide (NT-proBNP) on the risk of stroke in patients with transient ischemic attack (TIA). Methods The clinical data of 118 patients diagnosed with TIA in our hospital from February 2017 to May 2019 were retrospectively analyzed. 70 patients without stroke within 1 month were used as the control group, and 48 patients with stroke were used as the observation group. According to the National Institutes of Health Stroke Scale (NIHSS) score, it was divided into 18 patients with mild stroke, 16 patients with moderate stroke, and 14 patients with severe stroke. The related influencing factors of recent stroke in TIA patients were analyzed, and the four groups were compared NT-proBNP levels. Results There was no significant difference in unilateral limb weakness between the control group and observation group(P>0.05); comparing the ipsilateral carotid artery stenosis ≥50%, the presence of high DWI signal, and the duration of symptoms ≥10 min between the two groups were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that ipsilateral carotid artery stenosis ≥50%, high DWI signal, and symptom duration ≥10 min were independent factors affecting stroke in patients with TIA (P<0.05). The NT-proBNP level of mild, moderate, and severe stroke groups was higher than that in control groups (P<0.05); with the deepening of the severity of stroke, the level of NT-proBNP continued to increase, including mild stroke group

参考文献/References:

[1]吕祥龙,李婧.短暂性脑缺血发作后缺血性脑卒中的危险因素[J].临床神经病学杂志,2017,30(4):271-274.[2]唐敏,刘晓亭,朱幼玲,等.肢体抖动短暂性脑缺血发作的临床和影像学特点[J].临床神经病学杂志,2017,30(2):134-136.[3]李立健,饶绍奇,田镭钢,等.BNP或NT-proBNP对冠心病的临床意义[J].海南医学,2017,28(5):784-787.[4]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682.[5]张福波,张丽华,杨潮萍,等.基于ROC曲线分析ABCD3-Ⅰ和ABCD2-Ⅰ评分预测TIA患者继发脑卒中的临床价值[J].河北医药,2018,40(15):2295-2298.[6]Tu WJ,Ma GZ,Ni Y,et al.Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke[J].Neurology,2017,88(20):1899-1905.

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更新日期/Last Update: 2019-12-15