[1]曹自平,江豁达,姜良勇,等.乳腺癌Dab1、E-cad的表达及其在上皮间质转化中的作用[J].医学信息,2020,33(04):80-82.[doi:10.3969/j.issn.1006-1959.2020.04.024]
　CAO Zi-ping,JIANG Huo-da,JIANG Liang-yong,et al.Expression of Dab1,E-cad in Breast Cancer and Its Role in Epithelial-mesenchymal Transition[J].Medical Information,2020,33(04):80-82.[doi:10.3969/j.issn.1006-1959.2020.04.024]
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乳腺癌Dab1、E-cad的表达及其在上皮间质转化中的作用()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年04期
页码:
80-82
栏目:
论著
出版日期:
2020-02-15

文章信息/Info

Title:
Expression of Dab1,E-cad in Breast Cancer and Its Role in Epithelial-mesenchymal Transition
文章编号:
1006-1959（2020）04-0080-03
作者:
曹自平; 江豁达; 姜良勇; 等
（1.佳木斯大学，黑龙江 佳木斯 154007；2.佳木斯大学附属第一医院肿瘤外科，黑龙江 佳木斯 154003）
Author(s):
CAO Zi-ping; JIANG Huo-da; JIANG Liang-yong; et al
(1.Jiamusi University,Jiamusi 154007,Heilongjiang,China;2.Department of Oncology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,Heilongjiang,China)
关键词:
残障蛋白-1; E-钙粘蛋白; 上皮间质转化; 乳腺癌; 免疫组织化学
Keywords:
Disability protein-1; E-cadherin; Epithelial-mesenchymal transition; Breast cancer; Immunohistochemistry
分类号:
R737.31
DOI:
10.3969/j.issn.1006-1959.2020.04.024
文献标志码:
A
摘要:
目的 探讨乳腺癌残障蛋白-1（Dab1）与E-钙粘蛋白（E-cad）在乳腺癌中的表达及其与上皮间质转化（EMT）的相关性。方法 收集2018年3月~2019年3月佳木斯大学附属第一医院病理科乳腺癌组织与癌旁组织各80例，采用免疫组织化学方法检测乳腺癌Dab1和E-cad的表达，并分析其与患者临床病理特征的关系。结果 Dab1在乳腺癌组织中的阳性表达率为45.00%（36/80），在癌旁组织中的阳性表达率为75.00%（60/80）；E-cad在乳腺癌组织中的阳性表达率为60.00%（48/80），在癌旁组织中的阳性表达为85.00%（68/80），差异均有统计学意义（P＜0.05）；不同年龄、月经史、肿瘤大小间Dab1、E-cad阳性率比较，差异无统计学意义（P＞0.05）；不同TNM分期、分化程度及淋巴结转移情况间Dab1、E-cad阳性率比较，差异有统计学意义（P＜0.05）；Spearman相关分析显示，Dab1和E-cad呈正相关（r=0.226，P＜0.05）。结论 Dab1、E-cad在乳腺癌中异常表达，二者呈正相关，均与乳腺癌临床分期、肿瘤分化程度、淋巴结转移相关，可作为判断乳腺癌预后的指标。
Abstract:
Objective To investigate the expression of breast cancer disability protein-1(Dab1) and E-cadherin(E-cad)in breast cancer and their correlation with epithelial-mesenchymal transition (EMT).Methods From March 2018 to March 2019, 80 cases of breast cancer tissues and adjacent tissues from the Department of Pathology of the First Affiliated Hospital of Jiamusi University were selected.The expressions of Dab1 and E-cad in breast cancer were detected by immunohistochemistry,and their correlation with the relationship between the clinicopathological characteristics of patients.Results The positive expression rate of Dab1 in breast cancer tissues was 45.00% (36/80),and the positive expression rate in adjacent tissues was 75.00%(60/80).The positive expression rate of E-cad in breast cancer tissues 60.00%(48/80),the positive expression in the adjacent tissues was 85.00%(68/80),the differences were statistically significant(P＜0.05);There was no significant difference in Dab1, E-cad positive rates between different ages,menstrual history,and tumor size(P＞0.05);Dab1,E-cad positive rates were different among different TNM stages,degrees of differentiation, and lymph node metastasis,the difference was statistically significant(P＜0.05);Spearman correlation analysis showed that Dab1 and E-cad were positively correlated (r=0.226,P＜0.05).Conclusion Dab1 and E-cad are abnormally expressed in breast cancer.Both of them are positively correlated,and both are related to the clinical stage of breast cancer,the degree of tumor differentiation,and lymph node metastasis.Therefore,the two can be used as indicators to judge the prognosis of breast cancer.

参考文献/References:

[1]Dasgupta P,Aitken JF,Pyke C,et al.Competing mortality risks among women aged 50-79 years when diagnosed with invasive breast cancer,Queensland,1997-2012[J].Breast,2018(41):113-119. [2]Wei Z,Shan Z,Shaikh ZA.Epithelial-mesenchymal transition in breast epithelial cells treated with cadmium and the role of Snail[J].Toxicology and Applied Pharmacology,2018,344(1):46-55. [3]刘志娴,魏尔清,卢韵碧.上皮—间质转化在肿瘤发生发展中的作用研究进展[J].浙江大学学报(医学版),2015,44(2):211-216. [4]郭鱼波,王春晖,裴晓华.乳腺癌细胞上皮间质转化的分子机制及其防治的研究进展[J].中国肿瘤,2018,27(12):933-943. [5]雷珍,钟锡明,周岐,等.p53,Ki-67及E-钙粘蛋白在三阴性乳腺癌中的表达及预后[J].临床与病理杂志,2017(2):308-314. [6]da Cunha IW,Souza MJ,da Costa WH,et al.Epithelial-mesenchymal transition(EMT)phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes[J].Urol Oncol,2016,34(433):e19-e26. [7]Ortega FG,Alvarez-Cubero MJ,Nadal R,et al.EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer[J].Oncotarget,2014,5(17):7486-7497. [8]张建华.DCC介导的Dab1磷酸化参与调控新皮质神经元辐射迁移的研究[D].东北师范大学,2018. [9]王琼.Reelin-dab1信号转导通路在铝致Aβ代谢异常中的作用及其机制研究[D].山西医科大学,2018,31(8):3278-3281. [10]王同玫,张一奇,文普帅,等.乳腺癌组织中Dab1蛋白表达及其临床相关性研究[J].中国现代医学杂志,2018,28(15):32-36.

更新日期/Last Update: 2020-02-15