[1]吴述兵.高血压家族史对正常高值血压颈动脉内膜中层厚度及血清代谢指标的影响[J].医学信息,2020,33(04):83-86.[doi:10.3969/j.issn.1006-1959.2020.04.025]
　WU Shu-bing.Effects of Family History of Hypertension on Carotid Intima-media Thickness and Serum Metabolic Indexes of Normal High Blood Pressure[J].Medical Information,2020,33(04):83-86.[doi:10.3969/j.issn.1006-1959.2020.04.025]
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高血压家族史对正常高值血压颈动脉内膜中层厚度及血清代谢指标的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年04期
页码:
83-86
栏目:
论著
出版日期:
2020-02-15

文章信息/Info

Title:
Effects of Family History of Hypertension on Carotid Intima-media Thickness and Serum Metabolic Indexes of Normal High Blood Pressure
文章编号:
1006-1959（2020）04-0083-04
作者:
吴述兵
（兴山县人民医院内一科，湖北 兴山 443700）
Author(s):
WU Shu-bing
(Department of Internal Medicine,Subject One,Xingshan County People’s Hospital,Xingshan 443700,Hubei,China)
关键词:
高血压家族史; 正常高值血压; 代谢指标; 颈动脉内膜中层厚度
Keywords:
Family history of hypertension; Normal high blood pressure; Metabolic indicators; Carotid intima-media thickness
分类号:
R543
DOI:
10.3969/j.issn.1006-1959.2020.04.025
文献标志码:
A
摘要:
目的 探究高血压家族史患者正常高值血压对颈动脉内膜中层厚度（IMT）及血清代谢指标的影响。方法 回顾性分析2019年5月~7月我院体检的300名健康者的体检资料，依据血压值及是否存在高血压家族史分为血压值正常且无高血压家族史的A组（110名）、正常高值血压且无高血压家族史的B组（90名）、正常高值血压且伴高血压家族史的C组（100名），比较三组血清代谢指标、[胆固醇（CHO）、低密度脂蛋白（LDLC）、尿酸（UA）、同型半胱氨酸（Hcy）]、颈动脉IMT值，分析正常高值血压人群颈动脉IMT影响因素。结果 C组CHO、LDLC、UA、Hcy、IMT值高于A、B组，且B组CHO、LDLC、UA、Hcy、IMT值高于A组，差异有统计学意义（P＜0.05）；ROC曲线分析显示，IMT值评估正常高值血压人群伴高血压家族史的曲线下面积为0.821，临界值为0.91 mm；多因素Logistic回归分析显示，伴高血压家族史是正常高值血压人群颈动脉IMT增厚的危险因素（P＜0.05）。结论 伴高血压家族史患者正常高值血压有增厚IMT及增加血清代谢指标异常的风险，该类人群在健康体检时需重点筛查，以提高高血压疾病的防治。
Abstract:
Objective To investigate the effect of normal high blood pressure on carotid intima-media thickness (IMT) and serum metabolic indexes in patients with family history of hypertension.Methods The medical examination data of 300 healthy people undergoing physical examination in our hospital from May to July 2019 were retrospectively analyzed.According to blood pressure value and family history of hypertension, they were divided into group A (n=110) with normal blood pressure and no family history of hypertension, group B (n=90) without family history of hypertension, group C (n=100) with normal high blood pressure and family history of hypertension, compared serum metabolic indicators [cholesterol (CHO), low density lipoprotein (LDLC), uric acid (UA), homocysteine (Hcy)] and carotid IMT values of the three groups, and analyzed necks of people with normal high blood pressure factors influencing arterial IMT.Results The values of CHO, LDLC, UA, Hcy, and IMT in group C were higher than those in group A and B, and the values of CHO, LDLC, UA, Hcy, and IMT in group B were higher than those in group A,the differences were statistically significant (P<0.05); ROC curve The analysis showed that the area under the curve for assessing the family history of hypertension with IMT in normal high blood pressure was 0.821, and the cutoff was 0.91 mm.Multivariate Logistic regression analysis showed that a family history with hypertension was a risk factor for carotid IMT thickening in normal high blood pressure patients (P<0.05).Conclusion Patients with a family history of hypertension have a risk of thickening IMT and increasing abnormal serum metabolic indexes. This type of population needs to be screened during physical examination to improve the prevention and treatment of hypertension.

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更新日期/Last Update: 2020-02-15