[1]潘澄一,陈亚,江浩.联合肝脏离断门静脉结扎二步肝切除术(ALPPS)治疗肝恶性肿瘤的研究[J].医学信息,2020,33(08):55-57.[doi:10.3969/j.issn.1006-1959.2020.08.018]
　PAN Cheng-yi,CHEN Ya,JIANG Hao.The Application of Two-step Hepatectomy Combined with Liver Ligation of Portal Vein in the Treatment of Liver Malignant Tumors[J].Medical Information,2020,33(08):55-57.[doi:10.3969/j.issn.1006-1959.2020.08.018]
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联合肝脏离断门静脉结扎二步肝切除术(ALPPS)治疗肝恶性肿瘤的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年08期
页码:
55-57
栏目:
综述
出版日期:
2020-04-15

文章信息/Info

Title:
The Application of Two-step Hepatectomy Combined with Liver Ligation of Portal Vein in the Treatment of Liver Malignant Tumors
文章编号:
1006-1959（2020）08-0055-03
作者:
潘澄一; 陈亚; 江浩
（台州市中心医院/台州学院附属医院普外科，浙江 台州 317511）
Author(s):
PAN Cheng-yi; CHEN Ya; JIANG Hao
(Taizhou Central Hospital/Department of General Surgery,Taizhou University Affiliated Hospital,Taizhou 317511,Zhejiang,China)
关键词:
联合肝脏离断门静脉结扎二步肝切除术; 肝脏肿瘤; 肝切除
Keywords:
Two-step hepatectomy combined with liver ligation of portal vein; Liver tumor; Hepatectomy
分类号:
R735.7
DOI:
10.3969/j.issn.1006-1959.2020.08.018
文献标志码:
A
摘要:
肝癌是肝胆系统常见肿瘤，死亡率高，预后差。对于肝癌的治疗，目前治疗方式仍以根治性手术切除为主，而其中对于部分大肝癌甚至巨大肝癌患者，术后剩余肝体积（FLR）不足为手术禁忌之一。传统门静脉栓塞（PVE）与门静脉结扎（PVL）虽可促进FLR的增生，但仍存在术后FLR增生不足及长间歇内期肿瘤进展等问题。联合肝脏离断门静脉结扎二步肝切除术（ALPPS）是一种以诱导剩余肝脏快速生长以达到切除要求的新型手术方式，该术式为患者的诊治提供了另一种思路。然而ALPPS也因其术后并发症发生率高、死亡率高等备受争议。本文就ALPPS术式在治疗肝恶性肿瘤的应用现状、手术指征、手术争论焦点及优势等方面做一综述，以期为临床应用提供参考。
Abstract:
Liver cancer is a common tumor of the hepatobiliary system, with high mortality and poor prognosis. For the treatment of liver cancer, the current treatment is still based on radical surgical resection, and for some patients with large liver cancer or even huge liver cancer, the residual liver volume (FLR) is not one of the surgical contraindications. Although traditional portal vein embolization (PVE) and portal vein ligation (PVL) can promote FLR hyperplasia, there are still problems such as insufficient postoperative FLR hyperplasia and long-term intermittent tumor progression. Combined with liver dissection and portal vein ligation two-step hepatectomy (ALPPS) is a new surgical method that induces the rapid growth of the remaining liver to meet the requirements of resection. This procedure provides another way of diagnosis and treatment for patients. However, ALPPS is also controversial because of its high postoperative complication rate and high mortality rate. This article reviews the current status of application of ALPPS in the treatment of liver malignant tumors, indications for surgery, focus and advantages of surgery arguments, etc., in order to provide a reference for clinical application.

参考文献/References:

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更新日期/Last Update: 2020-04-15