[1]胡 玲,王思思,周乐汀,等.IL-10基因-819T/C多态性与糖尿病肾病易感性的Meta分析[J].医学信息,2020,33(10):61-64.[doi:10.3969/j.issn.1006-1959.2020.10.018]
　HU Ling,WANG Si-si,ZHOU Le-ting,et al.Meta Analysis of IL-10 Gene-819T/C Polymorphism and Susceptibility to Diabetic Nephropathy[J].Medical Information,2020,33(10):61-64.[doi:10.3969/j.issn.1006-1959.2020.10.018]
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IL-10基因-819T/C多态性与糖尿病肾病易感性的Meta分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年10期
页码:
61-64
栏目:
论著
出版日期:
2020-05-15

文章信息/Info

Title:
Meta Analysis of IL-10 Gene-819T/C Polymorphism and Susceptibility to Diabetic Nephropathy
文章编号:
1006-1959（2020）10-0061-04
作者:
胡 玲; 王思思; 周乐汀; 等
（南京医科大学附属无锡人民医院肾内科，江苏 无锡 214023）
Author(s):
HU Ling; WANG Si-si; ZHOU Le-ting; et al
(Department of Nephrology,Wuxi People’s Hospital,Nanjing Medical University,Wuxi 214023,Jiangsu,China)
关键词:
IL-10基因; -819T/C多态性; 糖尿病肾病; 易感性
Keywords:
IL-10 gene; -819T / C polymorphism; Diabetic nephropathy; Susceptibility
分类号:
R587.2；R692
DOI:
10.3969/j.issn.1006-1959.2020.10.018
文献标志码:
A
摘要:
目的 评价白细胞介素10（IL-10）基因-819T/C多态位点与糖尿病肾病（DN）易感性的关系。方法 检索PubMed、Embase、Medline、中国知网、维普数据库、万方数据库中与IL-10基因-819T/C多态性及DN发病相关的研究，检索时间为建库至2019年10月，使用纽卡斯尔渥太华（NOS）标准对纳入文献进行质量评价。以发病风险比值比（OR）及95%可信区间（CI）为效应指标，使用STATA12.0进行统计学分析。结果 共纳入7项病例对照研究，其中实验组均为DN患者，对照组为糖尿病（DM）患者或健康对照者（HC）。Meta分析结果显示：①DN组与对照组相比，IL-10基因-819T/C位点在等位基因模型（C vs. T：OR=0.999，P=0.990）、纯合子模型（CC vs. TT：OR=1.040，P=0.713）、显性模型（TC+CC vs. TT：OR=1.052，P=0.561）、隐性模型（CC vs. TC+TT：OR=0.993，P=0.954）、杂合子模型（TC vs. TT：OR=1.039，P=0.679）上的差异均无统计学意义（P＞0.05）；②地区亚组分析显示，在亚洲及中国人群中，DN组与对照组在各遗传模型上的差异均无统计学意义（P＞0.05）。结论 IL-10基因-819T/C多态性不增加DN易感性，在亚洲及中国地区人群中可得到类似结论，但仍需高质量的研究进一步验证。
Abstract:
Objective To evaluate the relationship between interleukin 10 (IL-10) gene-819T/C polymorphism and susceptibility to diabetic nephropathy (DN).Methods To search the studies related to IL-10 gene-819T/C polymorphism and DN incidence in PubMed, Embase, Medline, China HowNet, Weipu database, Wanfang database. The search time was from the establishment of the database to October 2019, use The Newcastle Ottawa (NOS) standard evaluates the quality of the included literature. Taking morbidity risk ratio (OR) and 95% confidence interval (CI) as the effect indicators, STATA12.0 was used for statistical analysis.Results A total of 7 case-control studies were included, in which the experimental group was all patients with DN, and the control group was patients with diabetes (DM) or healthy controls (HC). Meta analysis results showed that: ①Compared with the control group in the DN group,IL-10 gene-819T / C locus is in allele model (C vs. T: OR=0.999, P=0.990), homozygous model (CC vs. TT: OR=1.040, P=0.713), dominant Model (TC+CC vs. TT:OR=1.052, P=0.561), recessive model (CC vs. TC+TT:OR=0.993, P=0.954), heterozygous model (TC vs. TT:OR=1.039,P=0.679), there was no statistically significant difference(P>0.05); ②Analysis of regional subgroups showed that in Asian and Chinese populations, there were no statistically significant differences in genetic models between the DN group and the control group(P>0.05). Conclusion The IL-10 gene-819T/C polymorphism does not increase the susceptibility to DN. Similar conclusions can be obtained in populations in Asia and China, but high-quality research is still needed to further verify.

参考文献/References:

[1]Kishore L,Kaur N,Singh R.Distinct Biomarkers for Early Diagnosis of Diabetic Nephropathy[J].Curr Diabetes Rev,2017,13(6):598-605.[2]Wada J,Makino H.Inflammation and the pathogenesis of diabetic nephropathy[J].Clin Sci(Lond),2013,124(3):139-152.[3]Zhang X,Reinsmoen NL.Comprehensive assessment for serum treatment for single antigen test for detection of HLA antibodies[J].Hum Immunol,2017,78(11-12):699-703.[4]Mysliwska J,Zorena K,Semetkowska-Jurkiewicz E,et al.High levels of circulating interleukin-10 in diabetic nephropathy patients[J].Eur Cytokine Netw,2005,16(2):117-122.[5]咸伟,郑航,王素娟,等.血清IL-8、IL-10及IL-18水平与不同分期2型糖尿病肾病的关系[J].实用医学杂志,2013,29(13):2158-2160.[6]Shu Y,Chen Y,Luo H,et al.The Roles of IL-10 Gene Polymorphisms in Diabetes Mellitus and Their Associated Complications:A Meta-Analysis[J].Hormone&Metabolic Research,2018.[7]Stang A.Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J].Eur J Epidemiol,2010,25(9):603-605. [8]Chavarria-Buenrostro LE,Hernandez-Bello J,Munoz-Valle JF,et al.IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico[J].J Clin Lab Anal,2019,33(2):e22691.[9]Mtiraoui N,Ezzidi I,Kacem M,et al.Predictive value of interleukin-10 promoter genotypes and haplotypes in determining the susceptibility to nephropathy in type 2 diabetes patients[J].Diabetes Metab Res Rev,2009,25(1):57-63. [10]Fathy SA,Mohamed MR,Ali MAM,et al.Influence of IL-6,IL-10,IFN-γ and TNF-α genetic variants on susceptibility to diabetic kidney disease in type 2 diabetes mellitus patients[J].Biomarkers,2019,24(1):43-55.[11]Kung WJ,Lin CC,Liu SH,et al.Association of interleukin-10 polymorphisms with cytokines in type 2 diabetic nephropathy[J].Diabetes Technol Ther,2010,12(10):809-813. [12]Ma DH,Xu QY,Liu Y,et al.Association between interleukin-10 gene polymorphisms and susceptibility to diabetic nephropathy in a Chinese population[J].Genet Mol Res,2016,15(2):10. [13]Yin Q,Zhai Q,Wang D,et al.Investigation on the association between inerleukin-10 -592C/A,819C/T and -1082A/G gene polymorphisms and development of diabetic nephrophathy[J]. Int J Clin Exp Pathol,2015,8(11):15216-15221.[14]马东红,刘云,石岩,等.IL-10基因多态性与中国北方人群糖尿病肾病易感性的关系[J].重庆医学,2018,47(26):3390-3393.[15]葛景利,代青湘.糖尿病肾病治疗的研究进展综述[J].外科,2019,8(3):78-83.[16]卢葵花,黎荣.血清HPA及IL-10与2型糖尿病合并肾病的相关性分析[J].国际检验医学杂志,2018,39(14):1687-1690.[17]Sinuani I,Beberashvili I,Averbukh Z,et al.Role of IL-10 in the progression of kidney disease[J].World J Transplant,2013,3(4):91-98.

更新日期/Last Update: 2020-05-15