[1]严婧奕.卡贝缩宫素、卡前列素氨丁三醇治疗宫缩乏力性产后出血的效果及对产妇泌乳功能的影响[J].医学信息,2020,33(21):146-148.[doi:10.3969/j.issn.1006-1959.2020.21.045]
　YAN Jing-yi.The Effect of Carbetocin and Carboprost Tromethamine in the Treatment of Postpartum Hemorrhage due to Uterine Contraction and Their Influence on the Lactation Function of the Parturient[J].Medical Information,2020,33(21):146-148.[doi:10.3969/j.issn.1006-1959.2020.21.045]
点击复制

卡贝缩宫素、卡前列素氨丁三醇治疗宫缩乏力性产后出血的效果及对产妇泌乳功能的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年21期
页码:
146-148
栏目:
药物与临床
出版日期:
2020-11-01

文章信息/Info

Title:
The Effect of Carbetocin and Carboprost Tromethamine in the Treatment of Postpartum Hemorrhage due to Uterine Contraction and Their Influence on the Lactation Function of the Parturient
文章编号:
1006-1959（2020）21-0146-03
作者:
严婧奕
（常州市妇幼保健院妇产科，江苏 常州 213000）
Author(s):
YAN Jing-yi
(Department of Obstetrics and Gynecology,Changzhou Maternal and Child Health Hospital,Changzhou213000,Jiangsu,China)
关键词:
卡贝缩宫素; 卡前列素氨丁三醇; 宫缩乏力性产后出血; 泌乳功能
Keywords:
Carbetocin; Carboprost tromethamine; Postpartum hemorrhage due to uterine asthenia;  Lactation function
分类号:
R714.461
DOI:
10.3969/j.issn.1006-1959.2020.21.045
文献标志码:
A
摘要:
目的 探讨卡贝缩宫素、卡前列素氨丁三醇治疗宫缩乏力性产后出血的效果及对产妇泌乳功能的影响。方法 选取我院2018年1月~2020年1月收治的80例阴道分娩宫缩乏力产妇作为研究对象，随机分为对照组和观察组，各40例。对照组给予卡贝缩宫素治疗，观察组在此基础上联合卡前列素氨丁三醇治疗，比较两组产中出血量、产后2、24 h出血量及不良反应发生情况，记录两组泌乳始动时间及产后24、48 h泌乳量评分。结果 两组产中出血量比较，差异无统计学意义（P＞0.05）；观察组产后2、24 h出血量均少于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为15.00%，低于对照组的40.00%，差异有统计学意义（P＜0.05）；观察组泌乳始动时间短于对照组，差异有统计学意义（P＜0.05）；观察组产后24、48 h泌乳量评分分别为（1.62±0.78）分、（2.05±0.89）分，高于对照组的（1.23±0.69）分、（1.53±0.82）分，差异有统计学意义（P＜0.05）。结论 卡贝缩宫素联合卡前列素氨丁三醇治疗宫缩乏力性产后出血效果良好，可以有效减少产妇产后2、24 h出血量，不良反应少，安全性良好，同时可有效改善产妇泌乳功能，促进母体排乳，值得临床应用。
Abstract:
Objective To investigate the effects of carbetocin and carboprost tromethamine in the treatment of postpartum hemorrhage caused by uterine asthenia and their influence on the lactation function of parturients.Methods A total of 80 women with vaginal delivery and uterine attenuation admitted to our hospital from January 2018 to January 2020 were selected as the research objects, and they were randomly divided into a control group and an observation group, with 40 cases in each group. The control group was treated with carbetocin, and the observation group was treated with carboprost tromethamine on this basis. The amount of bleeding during delivery, the amount of bleeding at 2, 24 h after delivery and the occurrence of adverse reactions were compared between the two groups, and the two groups were recorded lactation initiation time and milk production score at 24 and 48 h postpartum.Results There was no statistically significant difference in the amount of bleeding during delivery between the two groups (P>0.05); the bleeding volume of the observation group at 2 and 24 h after delivery was less than that of the control group,the difference was statistically significant (P<0.05); adverse reactions in the observation group incidence was 15.00%, which was lower than 40.00% of the control group,the difference was statistically significant (P＜0.05); the observation group’s lactation initiation time was shorter than that of the control group,the difference was statistically significant (P＜0.05); postpartum observation group the milk production scores at 24 and 48 h were (1.62±0.78) and (2.05±0.89) points, which were higher than the control group’s (1.23±0.69) points and (1.53±0.82) points,the difference was statistically significant (P<0.05). Conclusion The combination of carbetocin and carboprost tromethamine was effective in treating postpartum hemorrhage caused by uterine asthenia. It could effectively reduce the amount of postpartum hemorrhage at 2 and 24 h after delivery, with few adverse reactions and good safety. At the same time, it could effectively improve maternal lactation function, promote maternal milk discharge, worthy of clinical application.

参考文献/References:

[1]和旭华,范晶晶,李艳霞. 缩宫素卡前列甲酯栓及卡前列素氨丁三醇注射液治疗宫缩乏力性产后出血的临床观察[J].中国药物与临床,2018,18(2):239-240.[2]茹仲轩.产后出血患者的临床抢救经验及临床效果探析[J].中外医学研究,2017,15(19):140-141.[3]殷筑萍,魏亚丽.观察益母草注射液对缩宫素治疗剖宫产子宫收缩性乏力产后出血的增效作用[J].母婴世界,2019(4):127.[4]张敏.卡贝缩宫素与卡前列腺素氨丁三醇防治瘢痕子宫剖宫产后出血的临床效果比较[J].中国计划生育学杂志,2017(25):779-780.[5]冯苗苗,邢梅.卡前列素氨丁三醇联合卡贝缩宫素对前置胎盘剖宫产产后出血的疗效观察[J].中国计划生育和妇产科,2017,9(9):56-58.[6]郑同英,钟思燕.卡贝缩宫素及卡前列素氨丁三醇联合产后出血预测评分表预防产后出血的临床研究[J].河北医学,2016, 22(7):1075-1078.[7]罗健敏,郭跃文,廖桂霞.卡前列素氨丁三醇联合卡贝缩宫素在产后出血患者中的应用效果观察[J].内蒙古医学杂志,2017, 49(2):154-156.[8]李洪书,覃春艳,余卢妹.预防性宫体注射卡前列素氨丁三醇在合并产后出血高危因素患者中的应用[J].海南医学,2017,28(15):2540-2541.[9]李舰.称重法测量产后出血的临床应用价值分析[J].临床医药文献电子杂志,2018,5(21):72.[10]管少英.无痛分娩对临床初产妇产后出血量、泌乳功能和母婴结局的影响[J].医学理论与实践,2016,29(13):1768-1770.[11]金李雪.卡前列素氨丁三醇联合卡贝缩宫素辅助预防前置胎盘剖宫产产后出血的效果[J].浙江实用医学,2017,22(2):142-144.[12]廖桂娟.宫缩乏力性产后出血的原因分析及护理对策[J].中国保健营养,2018,28(25):225-226.[13]劳力,张映辉,梁娇,等.卡贝缩宫素联合缩宫素预防人工流产后出血的临床研究[J].中国性科学,2018,27(2):128-130.[14]倪宇锦,李爱红.卡贝缩宫素预防产后出血的临床效果观察[J].锦州医科大学学报,2017,38(5):63-65.[15]刘亚男,石艳君.卡贝缩宫素联合欣母沛预防宫缩乏力性产后出血的效果分析[J].中国实用医药,2017,12(13):95-97.

相似文献/References:

[1]孙玉珍.卡前列素氨丁三醇对产后出血影响的临床效果[J].医学信息,2020,33(18):147.[doi:10.3969/j.issn.1006-1959.2020.18.049]
　SUN Yu-zhen.The Clinical Effect of Carboprost Tromethamine Injection on Postpartum Hemorrhage[J].Medical Information,2020,33(21):147.[doi:10.3969/j.issn.1006-1959.2020.18.049]
[2]卓明词,周柳红,易保连.静脉输注瑞芬太尼对剖宫产术中卡前列素氨丁三醇不良反应的影响[J].医学信息,2021,34(06):160.[doi:10.3969/j.issn.1006-1959.2021.06.042]
　ZHUO Ming-ci,ZHOU Liu-hong,YI Bao-lian.Effect of Intravenous Infusion of Remifentanil on Adverse Reactions of Carboprost Tromethamine During Cesarean Section[J].Medical Information,2021,34(21):160.[doi:10.3969/j.issn.1006-1959.2021.06.042]
[3]周 宏.缩宫素联合卡贝缩宫素在剖宫产术中子宫收缩乏力引起产后出血中的临床疗效及对血流动力学的影响[J].医学信息,2023,36(23):62.[doi:10.3969/j.issn.1006-1959.2023.23.015]
　ZHOU Hong.Clinical Efficacy of Oxytocin Combined with Carbetocin in Postpartum Hemorrhage Caused by Uterine Atony During Cesarean Section and its Effect on Hemodynamics[J].Medical Information,2023,36(21):62.[doi:10.3969/j.issn.1006-1959.2023.23.015]
[4]刘佩莲,龙小艳.卡前列素氨丁三醇联合缩宫素防治前置胎盘引起产后出血的效果[J].医学信息,2024,37(04):136.[doi:10.3969/j.issn.1006-1959.2024.04.025]
　LIU Pei-lian,LONG Xiao-yan.Effect of Carboprost Tromethamine Combined with Oxytocin on Prevention and Treatment of Postpartum Hemorrhage Caused by Placenta Previa[J].Medical Information,2024,37(21):136.[doi:10.3969/j.issn.1006-1959.2024.04.025]
[5]吴 丹.卡前列素氨丁三醇、麦角新碱、缩宫素三联疗法对阴道分娩产妇产后出血及子宫复旧的影响[J].医学信息,2024,37(15):107.[doi:10.3969/j.issn.1006-1959.2024.15.024]
　WU Dan.Effect of Triple Therapy of Carboprost Tromethamine, Ergometrine and Oxytocin on Postpartum Hemorrhage and Uterine Involution in Vaginal Delivery Women[J].Medical Information,2024,37(21):107.[doi:10.3969/j.issn.1006-1959.2024.15.024]
[6]简余清.缩宫素结合卡前列素氨丁三醇在高危妊娠分娩者产后出血治疗中的作用[J].医学信息,2024,37(22):78.[doi:10.3969/j.issn.1006-1959.2024.22.019]
　JIAN Yuqing.Effrect of Oxytocin Combined with Carboprost Tromethamine in the Treatment of Postpartum Hemorrhage in High-risk Pregnant Women[J].Medical Information,2024,37(21):78.[doi:10.3969/j.issn.1006-1959.2024.22.019]
[7]白建华.改良B-Lynch缝合术对产后出血患者并发症发生率及凝血功能指标的影响[J].医学信息,2025,38(24):123.[doi:10.3969/j.issn.1006-1959.2025.24.025]
　BAI Jianhua.Effect of Modified B-Lynch Suture on the Incidence of Complicationsand Coagulation Function in Patients with Postpartum Hemorrhage[J].Medical Information,2025,38(21):123.[doi:10.3969/j.issn.1006-1959.2025.24.025]

更新日期/Last Update: 1900-01-01