[1]冯美娜,杜远敏,许 康.MOG、AQP4抗体阳性NMOSD患者临床特征的Meta分析[J].医学信息,2021,34(08):76-80.[doi:10.3969/j.issn.1006-1959.2021.08.020]
　FENG Mei-na,DU Yuan-min,XU Kang.Meta-analysis of Clinical Characteristics of Patients with MOG and AQP4 Antibody Positive NMOSD[J].Medical Information,2021,34(08):76-80.[doi:10.3969/j.issn.1006-1959.2021.08.020]
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MOG、AQP4抗体阳性NMOSD患者临床特征的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年08期
页码:
76-80
栏目:
论著
出版日期:
2021-04-15

文章信息/Info

Title:
Meta-analysis of Clinical Characteristics of Patients with MOG and AQP4 Antibody Positive NMOSD
文章编号:
1006-1959（2021）08-0076-05
作者:
冯美娜; 杜远敏; 许 康
（武汉市长江航运总医院脑科医院神经内科，湖北 武汉 430015）
Author(s):
FENG Mei-na; DU Yuan-min; XU Kang
(Department of Neurology,Wuhan Brain Hosptial.General Hospital of the YANGTZE River Shipping,Wuhan 430015,Hubei,China)
关键词:
视神经脊髓炎谱系病; 髓鞘少突胶质细胞糖蛋白抗体; 水通道蛋白4抗体
Keywords:
Neuromyelitis optic spectrum diseases; Myelin oligodendrocyte glycoprotein antibody; Aquaporin 4 antibody
分类号:
R744.5
DOI:
10.3969/j.issn.1006-1959.2021.08.020
文献标志码:
A
摘要:
目的 系统比较髓鞘少突胶质细胞糖蛋白抗体（MOG-IgG）阳性和水通道蛋白4抗体（AQP4-IgG）阳性的视神经脊髓炎谱系疾病（NMOSD）患者的临床特征，旨在提高对MOG-IgG阳性NMOSD的认识。方法 检索万方数据库、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库 （CBM disc）、PubMed、EBASE等。按照纳入和排除标准进行筛选文献，采用Revman. 5.3进行数据处理。结果 共7篇文献、437例患者纳入研究。分为MOG-IgG阳性组和AQP4-IgG阳性组，Meta分析结果显示：MOG-IgG阳性组发病年龄要早于AQP4-IgG阳性组，差异有统计学意义[MD=-8.36，95%CI（-11.99，-4.73），P＜0.0001]；MOG-lgG阳性组视神经炎发病率高于AQP4-IgG阳性组，差异有统计学意义[OR=1.97，95%CI（1.07，3.62），P=0.03）]。AQP4-IgG阳性组头部MR典型病灶数及合并自身免疫疾病多于MOG-lgG阳性组[OR=0.29，95%CI（0.14，0.60），P=0.0007；OR=0.34，95%CI（0.13，0.90），P=0.03]。结论 MOG-IgG阳性NMOSD患者与AQP4-IgG阳性患者在发病年龄、临床和影像学表现及合并自身免疫疾病上存在一定差异，MOG-IgG可能成为AQP4-IgG阴性组新的生物标志物，MOG抗体介导的炎性脱髓鞘疾病可能成为IIDDs中的新的一种类型。
Abstract:
Objective To systematically compare the clinical characteristics of patients with neuromyelitis optica spectrum disease (NMOSD) who are positive for myelin oligodendrocyte glycoprotein antibody (MOG-IgG) and aquaporin 4 antibody (AQP4-IgG).It aims to increase the awareness of MOG-IgG positive NMOSD.Methods Searching Wanfang database, Chinese Academic Journal Full-text Database (CNKI), Chinese Biomedical Literature Database (CBM disc), PubMed, EBASE, etc.The literature was screened according to the inclusion and exclusion criteria, and Revman. 5.3 was used for data processing.Results A total of 7 articles and 437 patients were included in the study. Divided into MOG-IgG positive group and AQP4-IgG positive group, the results of Meta analysis showed that the age of onset of MOG-IgG positive group was earlier than that of AQP4-IgG positive group, and the difference was statistically significant [MD=-8.36, 95%CI( -11.99, -4.73), P＜0.0001];The incidence of optic neuritis in the MOG-lgG positive group was higher than that in the AQP4-IgG positive group,the difference was statistically significant [OR=1.97, 95%CI(1.07, 3.62), P=0.03)].The number of typical head MR lesions and combined autoimmune diseases in the AQP4-IgG positive group was more than that in the MOG-lgG positive group [OR=0.29, 95%CI(0.14, 0.60), P=0.0007; OR=0.34, 95%CI(0.13),0.90),P=0.03].Conclusion There are certain differences in age of onset, clinical and imaging findings, and autoimmune diseases between MOG-IgG-positive NMOSD patients and AQP4-IgG-positive patients. MOG-IgG may become a new biomarker of AQP4-IgG-negative group, MOG antibody Mediated inflammatory demyelinating diseases may become a new type of IIDDs.

参考文献/References:

[1]董慧卿.MOG抗体介导的特发性炎性脱髓鞘疾病[J].中国神经免疫学和神经病学杂志,2017,24(2):88-91. [2]阿丽亚克孜·艾合麦提,艾山江·玉素甫江,江沙晶,等.AQP４、MOG抗体阳性视神经脊髓炎谱系疾病的OCT评价[J].中国神经免疫学和神经病学杂志,2019,26(2):84-88. [3]姚海燕,黄清梅,邱伟,等.MOG抗体阳性视神经脊髓炎谱系疾病临床和影像学特点[J].中国神经精神疾病杂志,2018,44(11):646-650. [4]张植,张敏,刘恒方,等.MOG抗体阳性和AQP4抗体阳性NMOSD患者的临床及影像学分析[J].中风与神经疾病杂志,2018,35(10):873-876. [5]杜慧杰.抗AQP4-IgG抗体与抗MOG-IgG抗体的检测及与视神经脊髓炎谱系疾病的相关性分析[D].贵州医科大学,2016. [6]李昕頔,王化冰,周衡,等.脑脊液MOG抗体阳性的视神经脊髓炎谱系疾病患者的临床特征[J].中国神经免疫学和神经病学杂志,2017,24(4):249-255. [7]赵天佑,王静文,杨涛,等.血清MOG抗体阳性炎性脱髓鞘疾病患者临床特征分析[J].中国神经免疫学和神经病学杂志,2019,26(2):94-98. [8]Yan Y,Li Y,Fu Y,et al.Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD[J].Sci China Life Sci,2016,59(12):1270-1281. [9]Narayan R,Simpson A,Fritsche K,et al.MOGantibodydisease:A reviewof MOG antibody seropositive neuromyelitis optica spectrum disorder[J].Mult Scler Relat Disord,2018(25):66-72. [10]Reindl M,Di Pauli F,Rostasy K,et al.The spectrum of MOG autoantibody-associated demyelinating diseases[J].Nat Rev Neurol,2013(9):455-461. [11]Mader S,Gredler V,Schanda K,et al.Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders[J].J Neuro Inflammation,2011(8):184. [12]Saadoun S,Waters P,Owens GP,et al.Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain[J].Acta Neuropathol Commun,2014(2):35. [13]Bettelli E,Baeten D,Jager A,et al.Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice[J].J Clin Invest,2006,116(9):2393-2402. [14]Spadaro M,Gerdes LA,Krumbholz M,et al.Autoantibodies to MOG inadistinct subgroup of adult multiple sclerosis[J].Neurol Neuroimmunol Neuroinflamm,2016,3(5):e257. [15]Kitley J,Waters P,Woodhall M,et al.Neuromyelitis optica spectrum disorders with aquaporin-4 and myelinoligodendrocyte glycoprotein antibodies:a comparative study[J].JAMA Neurol,2014,71(3):276-278. [16]Sato DK,Callegaro D,Lana-Peixoto MA,et al.Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders[J].Neurology,2014,82(6):474-481. [17]Ramanathan S,Prelog K,Barnes EH,et al.Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoproteinantibodies, aquaporin-４ antibodies, andmultiple sclerosis[J].MultScler,2016,22(4):470-482. [18]Juryńczyk M,Jacob A,Fujihara K,et al.Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease: practical considerations[J].Pract Neurol,2019,19(3):187-195.

更新日期/Last Update: 1900-01-01