[1]韩玺铭,朱兵兵,刘凤霞,等.腰椎间盘退变与血糖、血脂、白介素-6、降钙素原的相关性分析[J].医学信息,2022,35(02):90-93.[doi:10.3969/j.issn.1006-1959.2022.02.022]
　HAN Xi-ming,ZHU Bing-bing,LIU Feng-xia,et al.Correlation Analysis of Lumbar Intervertebral Disc Degeneration with Blood Glucose,Blood Lipid,Interleukin-6 and Procalcitonin[J].Medical Information,2022,35(02):90-93.[doi:10.3969/j.issn.1006-1959.2022.02.022]
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腰椎间盘退变与血糖、血脂、白介素-6、降钙素原的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
90-93
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Correlation Analysis of Lumbar Intervertebral Disc Degeneration with Blood Glucose,Blood Lipid,Interleukin-6 and Procalcitonin
文章编号:
1006-1959（2022）02-0090-04
作者:
韩玺铭1; 朱兵兵1; 刘凤霞1; 马景旭2; 王 红2
1.新疆医科大学基础医学院，新疆 乌鲁木齐 830000；2.新疆医科大学第二附属医院影像科，新疆 乌鲁木齐 830011
Author(s):
HAN Xi-ming1; ZHU Bing-bing1; LIU Feng-xia1; MA Jing-xu2; WANG Hong2
1.Basic Medical College of Xinjiang Medical University,Urumqi 830000,Xinjiang,China;2.Department of Imaging,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China
关键词:
腰椎间盘; MRI加权成像; 炎性因子
Keywords:
Lumbar intervertebral disc; MRI weighted imaging; Inflammatory factors
分类号:
R73
DOI:
10.3969/j.issn.1006-1959.2022.02.022
文献标志码:
A
摘要:
目的 分析腰椎间盘退变与血糖、血脂、白介素-6（IL-6）、降钙素原的相关性的关系。方法 收集2017年9月-2020年6月新疆医科大学第二附属医院住院、门诊或体检的328名受试者临床资料，根据MRI检查结果分为正常对照组和腰椎间盘突出组，比较两组临床资料，分析腰椎间盘突出组Pfirrmann分级情况，并采用Spearman相关性分析Pfirrmann分级与各指标的相关性。结果 腰椎间盘突出组年龄、空腹血糖、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、糖化血红蛋白、IL-6与正常对照组比较，差异有统计学意义（P＜0.05）；两组性别、降钙素原比较，差异无统计学意义（P＞0.05）；腰椎间盘突出组共865个腰椎间盘，PfirrmannⅠ~Ⅴ级椎间盘数量依次为90、210、264、193、108个；磁共振T2WI矢位图像显示，部分腰椎间盘突出、椎间隙狭窄、信号低于脑脊液信号等影像表现；Spearman相关性分析显示，Pfirrmann分级与年龄、糖化血红蛋白、空腹血糖、胆固醇、甘油三酯、低密度脂蛋白、IL-6水平呈正相关（r=0.718、0.246、0.178、0.218、0.172、0.152、0.384，P＜0.05），与高密度脂蛋白水平呈负相关（r=-0.112，P＜0.05），与降钙素原无相关性（r=0.024，P＞0.05）。结论 血糖、血脂、IL-6上调以及高密度脂蛋白下调将加重腰椎间盘退变等级，增加腰椎间盘突出症的发病率。
Abstract:
Objective To analyze the correlation between lumbar disc degeneration and blood glucose, blood lipid, interleukin-6 and procalcitonin.Methods The clinical data of 328 subjects hospitalized, outpatient or physical examination in the Second Affiliated Hospital of Xinjiang Medical University from September 2017 to June 2020 were collected. According to the results of MRI examination, they were divided into normal control group and lumbar disc herniation group. The clinical data of the two groups were compared, and the Pfirrmann grading of lumbar disc herniation group was analyzed. Spearman correlation analysis was used to analyze the correlation between Pfirrmann grading and various indicators.Results There were significant differences in age, fasting blood glucose, cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, glycosylated hemoglobin and IL-6 between lumbar disc herniation group and normal control group (P<0.05). There was no significant difference in gender and procalcitonin between the two groups (P>0.05). There were 865 lumbar intervertebral discs in the lumbar disc herniation group, and the number of Pfirrmann Ⅰ-Ⅴ intervertebral discs was 90, 210, 264, 193 and 108, respectively. MRI T2WI sagittal images showed partial lumbar disc herniation, intervertebral space stenosis, signal lower than cerebrospinal fluid signal and other imaging manifestations. Spearman correlation analysis showed that Pfirrmann classification was positively correlated with age, glycosylated hemoglobin, blood glucose, cholesterol, triglyceride, low-density lipoprotein and interleukin-6 levels (r=0.718, 0.246, 0.178, 0.218, 0.172, 0.152, 0.384, P<0.05), was negatively correlated with HDL level (r=-0.112, P<0.05), and was no correlation with procalcitonin (r=0.024, P>0.05).Conclusion The up-regulation of blood glucose, blood lipid, interleukin-6 and down-regulation of high-density lipoprotein will aggravate the grade of lumbar disc degeneration and increase the incidence of lumbar disc herniation.

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更新日期/Last Update: 1900-01-01