[1]薛 梅,魏秀芹,康春博,等.SIX1和SIX4蛋白在结肠腺瘤性息肉中的表达和意义[J].医学信息,2022,35(02):118-120.[doi:10.3969/j.issn.1006-1959.2022.02.028]
　XUE Mei,WEI Xiu-qin,KANG Chun-bo,et al.Expression and Significance of SIX1 and SIX4 Protein in Colonic Adenomatous Polyp[J].Medical Information,2022,35(02):118-120.[doi:10.3969/j.issn.1006-1959.2022.02.028]
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SIX1和SIX4蛋白在结肠腺瘤性息肉中的表达和意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
118-120
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Expression and Significance of SIX1 and SIX4 Protein in Colonic Adenomatous Polyp
文章编号:
1006-1959（2022）02-0118-03
作者:
薛 梅; 魏秀芹; 康春博; 贾 伟; 张梦巧; 马 超; 王立伟; 高 强
首都医科大学附属北京康复医院消化科，北京 100144
Author(s):
XUE Mei; WEI Xiu-qin; KANG Chun-bo; JIA Wei; ZHANG Meng-qiao; MA Chao; WANG Li-wei; GAO Qiang
Department of Gastroenterology,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,China
关键词:
SIX1; SIX4; 结肠腺瘤性息肉; 结肠癌
Keywords:
SIX1; SIX4; Colorectal adenomatous polyp; Colon cancer
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2022.02.028
文献标志码:
A
摘要:
目的 探索SIX1和SIX4蛋白在结肠腺瘤性息肉中的表达及意义。方法 利用组织芯片及组织切片，通过免疫组化检测结肠腺瘤性息肉组织、结肠癌组织及癌旁组织中SIX1和SIX4蛋白的表达情况，分析结肠腺瘤性息肉中SIX1和SIX4蛋白表达的意义。结果 结肠腺瘤性息肉组织中SIX1、SIX4蛋白表达低于结肠癌组织，高于癌旁组织，差异有统计学意义（P＜0.05）；SIX1、SIX4蛋白表达在结肠腺瘤性息肉内定位于结肠上皮细胞质及细胞膜。结论 SIX1和SIX4可能在结肠腺瘤性息肉发生过程中发挥作用，检测SIX1和SIX4蛋白表达有助于结肠癌的早期诊断。
Abstract:
Objective To explore the expression and significance of SIX1 and SIX4 proteins in colorectal adenomatous polyps.Methods The expression of SIX1 and SIX4 proteins in colorectal adenomatous polyps, colon cancer tissues and paracancer tissues were detected by immunohistochemistry using tissue chips and sections, and the significance of SIX1 and SIX4 protein expression in colorectal adenomatous polyps was analyzed.Results The expression levels of SIX1 and SIX4 proteins in colon adenomatous polyp tissues were lower than those in colon cancer tissues, and higher than those in adjacent tissues, the difference was statistically significant (P<0.05). The expression of SIX1 and SIX4 proteins was localized in the cytoplasm and cell membrane of colon epithelial cells in colon adenomatous polyps.Conclusion SIX1 and SIX4 may play a role in the occurrence of colorectal adenomatous polyps. Detection of SIX1 and SIX4 protein expression may contribute to the early diagnosis of colon cancer.

参考文献/References:

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更新日期/Last Update: 1900-01-01