[1]欧志燕,奎 翔,易晓佳,等.SPC25在恶性肿瘤中的研究[J].医学信息,2022,35(19):167-171.[doi:10.3969/j.issn.1006-1959.2022.19.048]
 OU Zhi-yan,KUI Xiang,YI Xiao-jia,et al.Study of SPC25 in Malignant Tumor[J].Journal of Medical Information,2022,35(19):167-171.[doi:10.3969/j.issn.1006-1959.2022.19.048]
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SPC25在恶性肿瘤中的研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年19期
页码:
167-171
栏目:
综述
出版日期:
2022-10-01

文章信息/Info

Title:
Study of SPC25 in Malignant Tumor
文章编号:
1006-1959(2022)19-0167-05
作者:
欧志燕奎 翔易晓佳
(昆明医科大学第二附属医院病理科,云南 昆明 650101)
Author(s):
OU Zhi-yanKUI XiangYI Xiao-jiaet al.
(Department of Pathology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,Yunnan,China)
关键词:
SPC25Ndc80复合体恶性肿瘤
Keywords:
SPC25Ndc80 complexMalignant tumor
分类号:
R73
DOI:
10.3969/j.issn.1006-1959.2022.19.048
文献标志码:
A
摘要:
纺锤体成分25(SPC25)作为Ndc80复合体成员之一,是有丝分裂的重要调节因子,在染色体的分离过程中起着重要作用,同时也是纺锤体组装检查点所必须的,可维持遗传物质精确分配。SPC25异常表达会造成有丝分裂紊乱,导致细胞异常增殖,最终增加恶性肿瘤形成的几率。目前在多种恶性肿瘤中均发现SPC25过表达,研究SPC25在恶性肿瘤中的表达情况与患者预后及各项临床病理参数的相关性,探索SPC25在恶性肿瘤中的发生发展机制,寻求SPC25靶向治疗药物,充分发掘SPC25的应用价值,是为肿瘤患者寻得生机的重要途径。本文就SPC25在细胞分裂中的作用、SPC25在肝癌、肺癌、乳腺癌、前列腺癌和其他肿瘤中的研究及其在非肿瘤性病变中的研究作一综述。
Abstract:
SPC25, as a member of Ndc80 complex, is an important regulator of mitosis and plays an important role in chromosome separation. It is also necessary for spindle assembly checkpoint and maintains accurate distribution of genetic material. Abnormal expression of SPC25 results in mitosis disorder, which leads to abnormal cell proliferation and ultimately increases the risk of malignant tumor formation. At present, SPC25 overexpression has been found in a variety of malignant tumors,to study the correlation between the expression of SPC25 in malignant tumors and patient prognosis and various clinicopathological parameters, explore the occurrence and development mechanism of SPC25 in malignant tumors, seek targeted drugs for SPC25, and fully explore the application value of SPC25, it is an important way for cancer patients to find vitality. This article reviews the role of SPC25 in cell division, the research of SPC25 in liver cancer, lung cancer, breast cancer, prostate cancer and other tumors, and its research in non-neoplastic lesions.

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更新日期/Last Update: 1900-01-01