[1]陈明昊,青玉凤,苟婉星,等.绝经后骨质疏松症相关长链非编码RNA的研究进展[J].医学信息,2022,35(22):160-164.[doi:10.3969/j.issn.1006-1959.2022.22.040]
 CHEN Ming-hao,QING Yu-feng,GOU Wan-xing,et al.Research Progress of Long Non-coding RNA Related to Postmenopausal Osteoporosis[J].Journal of Medical Information,2022,35(22):160-164.[doi:10.3969/j.issn.1006-1959.2022.22.040]
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绝经后骨质疏松症相关长链非编码RNA的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年22期
页码:
160-164
栏目:
综述
出版日期:
2022-11-15

文章信息/Info

Title:
Research Progress of Long Non-coding RNA Related to Postmenopausal Osteoporosis
文章编号:
1006-1959(2022)22-0160-05
作者:
陈明昊青玉凤苟婉星
(川北医学院附属医院核医学科1,风湿免疫科2,四川 南充 637000)
Author(s):
CHEN Ming-haoQING Yu-fengGOU Wan-xinget al.
(Department of Nuclear Medicine1,Department of Rheumatism and Immunology2,Affiliated Hospital ofNorth Sichuan Medical College,Nanchong 637000,Sichuan,China)
关键词:
绝经后骨质疏松症长链非编码RNA雌激素微小RNA
Keywords:
Postmenopausal osteoporosisLong non-coding RNAEstrogenmicroRNA
分类号:
R681
DOI:
10.3969/j.issn.1006-1959.2022.22.040
文献标志码:
A
摘要:
绝经后骨质疏松症(PMOP)是绝经后妇女常见的全身性、代谢性骨病,以骨量降低和骨组织微结构破坏、退化为特征,增加了绝经后妇女骨折的风险。现有研究显示长链非编码RNA(lncRNA)在调节成骨细胞分化、破骨细胞分化等方面有重要作用。本文就lncRNA在PMOP中调控骨代谢的作用、与微小RNA(miRNA)及雌激素的相互作用等方面展开综述,以期为临床PMOP的诊治提供一定参考。
Abstract:
Postmenopausal osteoporosis (PMOP) is a common systemic and metabolic bone disease in postmenopausal women. It is characterized by decreased bone mass and destruction and degradation of bone microstructure, which increases the risk of fracture in postmenopausal women. Existing studies have shown that long non-coding RNA (lncRNA) plays an important role in regulating osteoblast differentiation and osteoclast differentiation. This article reviews the role of lncRNA in regulating bone metabolism in PMOP and its interaction with microRNA (miRNA) and estrogen, in order to provide some reference for the diagnosis and treatment of clinical PMOP.

参考文献/References:

[1]孙国平,罗选翔,潘彬.绝经后骨质疏松症的预防和药物联合序贯治疗[J].中国组织工程研究,2020,24(33):5385-5390.[2]Manolagas SC,O’Brien CA,Almeida M.The role of estrogen and androgen receptors in bone health and disease[J].Nat Rev Endocrinol,2013,9(12):699-712.[3]Batista PJ,Chang HY.Cytotopic localization by long noncoding RNAs[J].Curr Opin Cell Biol,2013,25(2):195-199.[4]Fu XD.Non-coding RNA: a new frontier in regulatory biology[J].Natl Sci Rev,2014,1(2):190-204.[5]Zuo C,Wang Z,Lu H,et al.Expression profiling of lncRNAs in C3H10T1/2 mesenchymal stem cells undergoing early osteoblast differentiation[J].Mol Med Rep,2013,8(2):463-467.[6]Peng S,Gao Y,Shi S,et al.LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation[J].Cell Prolif,2022,55(1):e13174.[7]Li T,Jiang H,Li Y,et al.Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p/SIRT1 axis[J].Mol Cell Endocrinol,2021,527:111171.[8]Song J,Song W,Zhang L.LncRNA RP1-85F18.6 affects osteoblast cells by regulating the cell cycle[J].Open Life Sci,2020,15(1):951-958.[9]Ko NY,Chen LR,Chen KH.The Role of Micro RNA and Long-Non-Coding RNA in Osteoporosis[J].Int J Mol Sci,2020,21(14):4886.[10]Shen JJ,Zhang CH,Chen ZW,et al.LncRNA HOTAIR inhibited osteogenic differentiation of BMSCs by regulating Wnt/β-catenin pathway[J].Eur Rev Med Pharmacol Sci,2019,23(17):7232-7246.[11]Yang K,Tian N,Liu H,et al.LncRNAp21 promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/β-catenin signaling pathway[J].Eur Rev Med Pharmacol Sci,2019,23(10):4303-4309.[12]Li D,Tian Y,Yin C,et al.Silencing of lncRNA AK045490 Promotes Osteoblast Differentiation and Bone Formation via β-Catenin/TCF1/Runx2 Signaling Axis[J].Int J Mol Sci,2019,20(24):6229.[13]Koirala P,Huang J,Ho TT,et al.LncRNA AK023948 is a positive regulator of AKT[J].Nat Commun,2017,8:14422.[14]Wang H,Zhao W,Tian QJ,et al.Effect of lncRNA AK023948 on rats with postmenopausal osteoporosis via PI3K/AKT signaling pathway[J].Eur Rev Med Pharmacol Sci,2020,24(5):2181-2188.[15]Zhang RF,Liu JW,Yu SP,et al.LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression[J].Eur Rev Med Pharmacol Sci,2019,23(16):6774-6782.[16]彭松林,王尚,王振民,等.长链非编码RNA作为绝经后妇女诊断骨质疏松标志物的可行性研究[J].骨科,2022,13(1):52-56.[17]Bellavia D,Salamanna F,Raimondi L,et al.Deregulated miRNAs in osteoporosis: effects in bone metastasis[J].Cell Mol Life Sci,2019,76(19):3723-3744.[18]Gao Y,Xiao F,Wang C,et al.Long noncoding RNA MALAT1 promotes osterix expression to regulate osteogenic differentiation by targeting miRNA-143 in human bone marrow-derived mesenchymal stem cells[J].J Cell Biochem,2018,119(8):6986-6996.[19]Peng S,Cao L,He S,et al.An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells[J].Stem Cells Int,2018,2018:8273648.[20]Peng W,Zhu SX,Wang J,et al.Lnc-NTF3-5 promotes osteogenic differentiation of maxillary sinus membrane stem cells via sponging miR-93-3p[J].Clin Implant Dent Relat Res,2018,20(2):110-121.[21]Feng L,Shi L,Lu YF,et al.Linc-ROR Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Functioning as a Competing Endogenous RNA for miR-138 and miR-145[J].Mol Ther Nucleic Acids,2018,11:345-353.[22]Wei B,Wei W,Zhao B,et al.Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head[J].PLoS One,2017,12(2):e0169097.[23]Wang Q,Li Y,Zhang Y,et al.LncRNA MEG3 inhibited osteogenic differentiation of bone marrow mesenchymal stem cells from postmenopausal osteoporosis by targeting miR-133a-3p[J].Biomed Pharmacother,2017,89:1178-1186.[24]Cai N,Li C,Wang F.Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2[J].Yonsei Med J,2019,60(8):751-759.[25]Yin C,Tian Y,Yu Y,et al.A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation[J].J Cell Physiol,2019,234(7):11524-11536.[26]Zhang W,Dong R,Diao S,et al.Differential long noncoding RNA/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells[J].Stem Cell Res Ther,2017,8(1):30.[27]Xiaoling G,Shuaibin L,Kailu L.MicroRNA-19b-3p promotes cell proliferation and osteogenic differentiation of BMSCs by interacting with lncRNA H19[J].BMC Med Genet,2020,21(1):11.[28]Xu SY,Shi P,Zhou RM.Post-menopausal oestrogen deficiency induces osteoblast apoptosis via regulating HOTAIR/miRNA-138 signalling and suppressing TIMP1 expression[J].J Cell Mol Med,2021,25(10):4572-4582.[29]Aiello A,Bacci L,Re A,et al.MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells[J].Sci Rep,2016,6:38414.[30]Zhou Z,Hossain MS,Liu D.Involvement of the long noncoding RNA H19 in osteogenic differentiation and bone regeneration[J].Stem Cell Res Ther,2021,12(1):74.[31]Al-Momen H,Jasim SK,Hassan QA,et al.Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia[J].Blood Res,2018,53(4):314-319.[32]Schor IE,Bussotti G,Males M,et al.Non-coding RNA Expression, Function, and Variation during Drosophila Embryogenesis[J].Curr Biol,2018,28(22):3547-3561.e9.[33]Yuan H,Xu X,Feng X,et al.A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p[J].Cell Death Differ,2019,26(10):2029-2045.[34]Li CJ,Xiao Y,Yang M,et al.Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging[J].J Clin Invest,2018,128(12):5251-5266.[35]Yang L,Li Y,Gong R,et al.The Long Non-coding RNA-ORLNC1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Fate[J].Mol Ther,2019,27(2):394-410.[36]Rachner TD,Khosla S,Hofbauer LC.Osteoporosis: now and the future[J].Lancet,2011,377(9773):1276-1287.[37]Liu C,Cao Z,Bai Y,et al.LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45[J].J Cell Physiol,2019,234(2):1606-1617.[38]Lee CP,Huang YN,Nithiyanantham S,et al.LncRNA-Jak3:Jak3 coexpressed pattern regulates monosodium urate crystal-induced osteoclast differentiation through Nfatc1/Ctsk expression[J].Environ Toxicol,2019,34(2):179-187.[39]Wang Y,Luo TB,Liu L,et al.LncRNA LINC00311 Promotes the Proliferation and Differentiation of Osteoclasts in Osteoporotic Rats Through the Notch Signaling Pathway by Targeting DLL3[J].Cell Physiol Biochem,2018,47(6):2291-2306.[40]Han Y,Liu C,Lei M,et al.LncRNA TUG1 was upregulated in osteoporosis and regulates the proliferation and apoptosis of osteoclasts[J].J Orthop Surg Res,2019,14(1):416.[41]Chen RS,Zhang X B,Zhu X T,et al.LncRNA Bmncr alleviates the progression of osteoporosis by inhibiting RANML-induced osteoclast differentiation[J].Eur Rev Med Pharmacol Sci,2019,23(21):9199-9206.[42]Yuan H,Xu X,Feng X,et al.A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p[J].Cell Death Differ,2019,26(10):2029-2045.[43]Li W,Zhu H M,Xu H D,et al.CRNDE impacts the proliferation of osteoclast by estrogen deficiency in postmenopausal osteoporosis[J].Eur Rev Med Pharmacol Sci,2018,22(18):5815-5821.[44]Shao Y,Hu X,Wu X.LncRNA X inactive-specific transcript promotes osteoclast differentiation through Tgif2 by acting as a ceRNA of miR-590-3p in a murine model[J].Regen Med,2021,16(7):643-653.[45]Wang Y,Zhu G,Pei F,et al.lncRNA SNHG15 as a ceRNA modulates Osteoclast Differentiation, Proliferation, and Metastasis by Sponging miR-381-3p/NEK2 Axis[J].J Immunol Res,2022,2022:8634820.[46]Huang S,Zhu X,Xiao D,et al.LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis[J].Biosci Rep,2019,39(11):BSR20190445.[47]Quan H,Liang M,Li N,et al.LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells[J].Cell Physiol Biochem,2018,46(1):401-417.

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更新日期/Last Update: 1900-01-01