[1]雷 婧.肝功能检验对甲状腺功能亢进患者代谢紊乱程度的检测价值[J].医学信息,2022,35(23):153-155,162.[doi:10.3969/j.issn.1006-1959.2022.23.033]
　LEI Jing.Value of Liver Function Test in Detecting Metabolic Disorders in Patients with Hyperthyroidism[J].Journal of Medical Information,2022,35(23):153-155,162.[doi:10.3969/j.issn.1006-1959.2022.23.033]
点击复制

肝功能检验对甲状腺功能亢进患者代谢紊乱程度的检测价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年23期
页码:
153-155,162
栏目:
诊疗技术
出版日期:
2022-12-01

文章信息/Info

Title:
Value of Liver Function Test in Detecting Metabolic Disorders in Patients with Hyperthyroidism
文章编号:
1006-1959（2022）23-0153-04
作者:
雷 婧
（天津市河西医院检验科，天津 300202）
Author(s):
LEI Jing
(Department of Laboratory,Tianjin Hexi Hospital,Tianjin 300202,China)
关键词:
甲状腺功能亢进; 肝功能; 甲状腺激素; 高代谢状态; 谷丙转氨酶
Keywords:
Hyperthyroidism; Liver function; Thyroid hormone; Hypermetabolic state; Alanine aminotransferase
分类号:
R581.1
DOI:
10.3969/j.issn.1006-1959.2022.23.033
文献标志码:
A
摘要:
目的 探究肝功能检验对甲状腺功能亢进患者代谢紊乱程度的检测价值。方法 将2020年7月-2021年7月天津市河西医院收治的50例甲亢患者设为甲状腺功能亢进组，以同期50名体检健康者设为对照组，比较两组甲状腺功能[促甲状腺素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）]、肝功能指标[总胆红素（TBiL）、直接胆红素（DBiL）、总蛋白（TP）、白蛋白（ALB）、谷丙转氨酶（ALT）、谷草转氨酶（AST）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）]、肝功能异常率，并分析二者相关性。结果 甲状腺功能亢进组TSH低于对照组，FT3、FT4高于对照组（P＜0.05）；甲状腺功能亢进组TBiL、DBiL、ALT、AST、ALP、GGT高于对照组，TP、ALB低于对照组（P＜0.05）；甲状腺功能亢进组TBiL、DBiL、TP、ALB、ALT、AST、ALP、GGT异常率均高于对照组（P＜0.05）；Pearson相关性分析显示，FT3、FT4与TBiL、DBiL、ALT、AST、ALP、GGT呈正相关，与TP、ALB呈负相关（P＜0.05）；TSH与TBiL、DBiL、ALT、AST、ALP、GGT、TP、ALB无相关性（P＞0.05）。结论 肝功能指标与甲状腺激素水平密切相关，在甲状腺功能亢进疾病中具有一定检测价值。
Abstract:
Objective To explore the value of liver function test in detecting metabolic disorders in patients with hyperthyroidism.Methods Fifty patients with hyperthyroidism admitted to Tianjin Hexi Hospital from July 2020 to July 2021 were set as hyperthyroidism group, and 50 healthy subjects were set as control group. The thyroid function [thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)], liver function indexes [total bilirubin (TBiL), direct bilirubin (DBiL), total protein (TP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT)] and abnormal rate of liver function were compared between the two groups, and the correlation between the two was analyzed.Results TSH in hyperthyroidism group was lower than that in control group, FT3 and FT4 were higher than those in control group (P<0.05). TBiL, DBiL, ALT, AST, ALP and GGT in hyperthyroidism group were higher than those in control group, TP and ALB were lower than those in control group (P<0.05). The abnormal rates of TBiL, DBiL, TP, ALB, ALT, AST, ALP and GGT in hyperthyroidism group were higher than those in control group (P<0.05). Pearson correlation analysis showed that FT3 and FT4 were positively correlated with TBiL, DBiL, ALT, AST, ALP and GGT, and negatively correlated with TP and ALB (P<0.05). TSH was not correlated with TBiL, DBiL, ALT, AST, ALP, GGT, TP and ALB (P>0.05).Conclusion Liver function indexes are closely related to thyroid hormone levels, and have certain detection value in hyperthyroidism.

参考文献/References:

[1]盛秋菊,丁洋,张翀,等.甲状腺功能亢进症合并肝损伤患者的临床特点分析[J].中华肝脏病杂志,2021,29(10):967-971.[2]贾晨雨,郭丹,林震宇,等.甲状腺功能亢进性肝损害与甲巯咪唑继发性肝损害的临床比较研究[J].临床内科杂志,2020,37(1):23-26.[3]张玲云,张国全,贾涛,等.彩色多普勒超声对甲亢患者甲状腺血流分级与功能指标的关系研究[J].医学影像学杂志,2020,30(8):1357-1360.[4]盛秋菊,丁洋,张翀,等.甲状腺功能亢进症合并肝损伤患者的临床特点分析[J].中华肝脏病杂志,2021,29(10):967-971.[5]肖金玉,王晓胥,康联宗.甲亢性肝病患者血清学指标检验及临床价值分析[J].贵州医药,2019,43(9):1481-1482.[6]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.甲状腺功能亢进症基层诊疗指南(实践版·2019)[J].中华全科医师杂志,2019(12):1129-1135.[7]路娜,冉晓丹,李永伟,等.甲状腺球蛋白及游离甲状腺素/游离三碘甲状腺原氨酸联合甲状腺激素抗体在亚急性甲状腺炎诊断中的应用价值研究[J].中国全科医学,2019,22(3):361-365.[8]Zhang W,Wang X,Li P,et al.Evaluating Hyperthyroidism-Induced Liver Injury Based on In Situ Fluorescence Imaging of Glutathione and Phosphate via Nano-MOFs Sensor[J].Analytical Chemistry,2020,92(13):8952-8958.[9]吕飒,朱冰,徐天娇,等.甲状腺功能亢进症重度肝损伤患者的治疗模式[J].肝脏,2020,25(11):1212-1215.[10]陈杨,凌婉彬,陈曦.联合检测LAP、ALT、γ-GT对甲状腺功能亢进肝损害诊断价值的探讨[J].标记免疫分析与临床,2018,25(6):847-850.[11]Saemi F,Shahneh AZ,Zhandi M,et al.Long-term induced hyperthyroidism in breeder hens: Effects on blood plasma biochemical attributes, indicators of oxidative stress, and markers of liver function[J].Livestock Science,2018,218:26-30.[12]陈赟,马维青,何瑶,等.Graves病患者并发甲亢性肝功能损害的临床特征及相关因素分析[J].江苏医药,2017,43(21):1522-1525.[13]符宝林,符星.甲巯咪唑与丙硫氧嘧啶对甲状腺功能亢进患者肝功能影响的临床对照研究[J].药物评价研究,2017,40(4):545-548.[14]张红卫,周琳,乔丽.不同阶段妊娠期甲状腺功能亢进症患者的甲状腺功能变化[J].中国妇幼保健,2016,31(9):1819-1821.[15]孙可歆,李锋,王子宇,等.甲状腺功能减退患者血清FGF-21的表达水平及其生化指标相关性分析[J].中国地方病防治杂志,2016,31(11):1240-1241.[16]柯比努尔.吐尔逊,韩丹,张跃新.肝硬化患者血清促甲状腺激素和甲状腺素水平变化及其临床意义[J].实用肝脏病杂志,2017,20(6):764-766.[17]杨艳艳,李治锋,王静.甲状腺功能亢进症初诊患者的肝功能检验项目评价[J].国际检验医学杂志,2016,37(19):2779-2781.[18]李前进,董永辉,赵福岩.T淋巴细胞及炎症因子水平变化与甲亢性肝损害相关性分析[J].医学临床研究,2020,37(8):1220-1222.

相似文献/References:

[1]解春军.损伤性胆管狭窄手术时机对肝功能变化影响的实验研究[J].医学信息,2018,31(03):78.[doi:10.3969/j.issn.1006-1959.2018.03.024]
　XIE Chun-jun.Experimental Study on the Influence of Timing of Operation on the Changes of Hepatic Function in Patients with Traumatic Biliary Stricture[J].Journal of Medical Information,2018,31(23):78.[doi:10.3969/j.issn.1006-1959.2018.03.024]
[2]张 黎.中晚期原发性肝癌介入治疗的临床效果及对 肝功能的影响[J].医学信息,2018,31(09):20.[doi:10.3969/j.issn.1006-1959.2018.09.006]
　ZHANG Li.The Clinical Effect of Interventional Treatment of Primary Liver Cancer in Middle and Late Stage and its Effect on Liver Function[J].Journal of Medical Information,2018,31(23):20.[doi:10.3969/j.issn.1006-1959.2018.09.006]
[3]刘钰书.茵陈蒿汤辅助治疗热重于湿型病毒性肝炎患者的效果研究[J].医学信息,2018,31(14):156.[doi:10.3969/j.issn.1006-1959.2018.14.048]
　LIU Yu-shu.Effect of Yinchenhao Decoction on the Treatment of Patients with Heat Heavier than Wet Type Viral Hepatitis[J].Journal of Medical Information,2018,31(23):156.[doi:10.3969/j.issn.1006-1959.2018.14.048]
[4]蒋红梅.丙基硫氧嘧啶与甲巯咪唑治疗妊娠合并甲状腺功能亢进的疗效比较[J].医学信息,2019,32(05):154.[doi:10.3969/j.issn.1006-1959.2019.05.049]
　JIANG Hong-mei.Comparison of Propyl Thiouracil and Methimazole in the Treatment of Pregnancy with Hyperthyroidism[J].Journal of Medical Information,2019,32(23):154.[doi:10.3969/j.issn.1006-1959.2019.05.049]
[5]潘 文,屈 阳,米 俊,等.蜂毒清1号对轻中度毒蜂蜇伤患者心肝肾功能影响的临床研究[J].医学信息,2019,32(06):151.[doi:10.3969/j.issn.1006-1959.2019.06.048]
　PAN Wen,QU Yang,MI Jun,et al.Clinical Study on the Effect of Fengduqing No.1 on Heart,Liver and Kidney Function of Patients with Mild to Moderate Poison Bee Sting[J].Journal of Medical Information,2019,32(23):151.[doi:10.3969/j.issn.1006-1959.2019.06.048]
[6]谢春燕.化学发光免疫分析法在甲状腺疾病诊断中的应用[J].医学信息,2019,32(16):169.[doi:10.3969/j.issn.1006-1959.2019.16.058]
　XIE Chun-yan.Application of Chemiluminescence Immunoassay in the Diagnosis of Thyroid Diseases[J].Journal of Medical Information,2019,32(23):169.[doi:10.3969/j.issn.1006-1959.2019.16.058]
[7]周 煜.恩替卡韦联合微生态制剂对乙肝肝硬化患者肝功能及预后的影响[J].医学信息,2019,32(22):132.[doi:10.3969/j.issn.1006-1959.2019.22.044]
　ZHOU Yu.Effect of Entecavir Combined with Microecological Preparation on Liver Function and Prognosis in Patients with Hepatitis B Cirrhosis[J].Journal of Medical Information,2019,32(23):132.[doi:10.3969/j.issn.1006-1959.2019.22.044]
[8]黄士昌.标本温度、存储时间对肝功能生化检验结果的影响[J].医学信息,2019,32(22):172.[doi:10.3969/j.issn.1006-1959.2019.22.061]
　HUANG Shi-chang.Effect of Specimen Temperature and Storage Time on Biochemical Test Results of Liver Function[J].Journal of Medical Information,2019,32(23):172.[doi:10.3969/j.issn.1006-1959.2019.22.061]
[9]王 晶.垂体后叶素联合硝酸甘油治疗肝硬化上消化道出血的效果[J].医学信息,2020,33(19):147.[doi:10.3969/j.issn.1006-1959.2020.19.046]
　WANG Jing.Effect of Pituitrin and Nitroglycerin on Upper Gastrointestinal Bleeding in Cirrhosis[J].Journal of Medical Information,2020,33(23):147.[doi:10.3969/j.issn.1006-1959.2020.19.046]
[10]毛 锋.标本溶血对生化检验中电解质、心肌酶、肝功能、血脂水平的影响[J].医学信息,2020,33(19):173.[doi:10.3969/j.issn.1006-1959.2020.19.056]
　MAO Feng.The Effect of Specimen Hemolysis on Electrolytes,Myocardial Enzymes, Liver Functionand Blood Lipid Levels in Biochemical Tests[J].Journal of Medical Information,2020,33(23):173.[doi:10.3969/j.issn.1006-1959.2020.19.056]

更新日期/Last Update: 1900-01-01