[1]龚晓芹,钟 平.CYP2C19基因多态性与急性脑梗死及病灶面积的相关性[J].医学信息,2023,36(06):85-88,138.[doi:10.3969/j.issn.1006-1959.2023.06.018]
　GONG Xiao-qin,ZHONG Ping.Correlation Between CYP2C19 Gene Polymorphism and Acute Cerebral Infarction and Lesion Size[J].Journal of Medical Information,2023,36(06):85-88,138.[doi:10.3969/j.issn.1006-1959.2023.06.018]
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CYP2C19基因多态性与急性脑梗死及病灶面积的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年06期
页码:
85-88,138
栏目:
论著
出版日期:
2023-03-15

文章信息/Info

Title:
Correlation Between CYP2C19 Gene Polymorphism and Acute Cerebral Infarction and Lesion Size
文章编号:
1006-1959（2023）06-0085-05
作者:
龚晓芹; 钟 平
（安徽医科大学附属宿州医院神经内科，安徽 宿州 234000）
Author(s):
GONG Xiao-qin; ZHONG Ping
(Department of Neurology,Suzhou Hospital Affiliated to Anhui Medical University,Suzhou 234000,Anhui,China)
关键词:
CYP2C19基因多态性; 脑梗死; 病灶面积
Keywords:
CYP2C19 gene polymorphism; Cerebral infarction; Lesion area
分类号:
R743.33
DOI:
10.3969/j.issn.1006-1959.2023.06.018
文献标志码:
A
摘要:
目的 探究细胞色素P450同工酶亚族2C19（CYP2C19）基因多态性与急性脑梗死及患者病灶面积的关系。方法 选取2021年11月-2022年6月在我院神经内科就诊的无血缘关系的汉族患者213例，根据磁共振表现、临床表现分为急性脑梗死组（142例）及对照组（非急性脑梗死组71例），均行CYP2C19基因多态性检测，比较两组临床资料（性别、年龄、BMI、颈动脉硬化形成、低密度脂蛋白、ADL评分、血糖等）、CYP2C19基因型、等位基因分布频率，Logistic回归分析该基因多态性与急性脑梗死的相关性；141例急性脑梗死患者按照梗死面积分为大面积梗死组（直径≥4 cm）和非大面积梗死组（直径＜4 cm），分析基因型与等位基因在脑梗死与非脑梗死及脑梗死不同病灶面积间分布的差异。结果 急性脑梗死组与对照组血糖、低密度脂蛋白、ADL评分、颈动脉斑块形成比例比较，差异有统计学意义（P＜0.05）；急性脑梗死组与对照组基因型、等位基因分布频率比较，差异无统计学意义（P＞0.05）；大面积脑梗死组CYP2C19*1/*1基因型及CYP2C19*1等位基因分布频率低于非大面积梗死组，差异有统计学意义（P＜0.05）；Logistic多因素回归分析显示，血糖、低密度脂蛋白、颈动脉彩超、ADL评分是急性脑梗死发病的独立危险因素；CYP2C19基因型与急性脑梗死的发病无明显相关性。结论 血糖、低密度脂蛋白、颈动脉彩超、ADL评分是急性脑梗死发病的独立危险因素，CYP2C19基因多态性与急性脑梗死的发生无明显相关，但可能与病灶面积大小有一定相关性。
Abstract:
Objective To investigate the relationship between cytochrome P450 isoenzyme subfamily 2C19 (CYP2C19) gene polymorphism and acute cerebral infarction and lesion area.Methods A total of 213 unrelated Han patients who were treated in the Department of Neurology of our hospital from November 2021 to June 2022 were selected. According to magnetic resonance imaging and clinical manifestations, they were divided into acute cerebral infarction group (142 cases) and control group (non-acute cerebral infarction group 71 cases). CYP2C19 gene polymorphism was detected. The clinical data (gender, age, BMI, carotid atherosclerosis, low density lipoprotein, ADL score, blood glucose, etc.), CYP2C19 genotype and allele distribution frequency were compared between the two groups. Logistic regression analysis was used to analyze the correlation between CYP2C19 gene polymorphism and acute cerebral infarction. According to the infarct size, 141 patients with acute cerebral infarction were divided into large area infarction group (diameter≥ 4 cm) and non-large area infarction group (diameter<4 cm). The differences of genotype and allele distribution between cerebral infarction and non-cerebral infarction and different lesion areas of cerebral infarction were analyzed.Results There were significant differences in blood glucose, low density lipoprotein, ADL score and carotid plaque formation ratio between acute cerebral infarction group and control group, the difference was statistically significant (P<0.05). There was no significant difference in the distribution frequency of genotype and allele between acute cerebral infarction group and control group (P>0.05). The distribution frequency of CYP2C19 *1/*1 genotype and CYP2C19*1 allele in large area cerebral infarction group was lower than that in non-large area cerebral infarction group, and the difference was statistically significant (P<0.05). Logistic multivariate regression analysis showed that blood glucose, low density lipoprotein, carotid ultrasound and ADL score were independent risk factors for acute cerebral infarction. There was no significant correlation between CYP2C19 genotype and acute cerebral infarction.Conclusion Blood glucose, low density lipoprotein, carotid ultrasound and ADL score are independent risk factors for acute cerebral infarction. CYP2C19 gene polymorphism is not significantly related to the occurrence of acute cerebral infarction, but may be related to the size of lesion area.

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更新日期/Last Update: 1900-01-01