[1]汤百惠,苏建男,林先和.TyG指数联合甘油三酯/高密度脂蛋白胆固醇比值对NSTE-ACS患者冠状动脉病变严重程度的预测价值[J].医学信息,2023,36(17):88-92,97.[doi:10.3969/j.issn.1006-1959.2023.17.016]
 TANG Bai-hui,SU Jian-nan,LIN Xian-he.Predictive Value of TyG Index Combined with Triglyceride/High Density Lipoprotein Cholesterol Ratio on the Severity of Coronary Artery Lesions in Patients with NSTE-ACS[J].Journal of Medical Information,2023,36(17):88-92,97.[doi:10.3969/j.issn.1006-1959.2023.17.016]
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TyG指数联合甘油三酯/高密度脂蛋白胆固醇比值对NSTE-ACS患者冠状动脉病变严重程度的预测价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年17期
页码:
88-92,97
栏目:
论著
出版日期:
2023-09-01

文章信息/Info

Title:
Predictive Value of TyG Index Combined with Triglyceride/High Density Lipoprotein Cholesterol Ratio on the Severity of Coronary Artery Lesions in Patients with NSTE-ACS
文章编号:
1006-1959(2023)17-0088-06
作者:
汤百惠苏建男林先和
(安徽医科大学第一附属医院心血管内科,安徽 合肥 230001)
Author(s):
TANG Bai-huiSU Jian-nanLIN Xian-he
(Department of Cardiovascular Medicine,the First Affiliated Hospital of Anhui Medical University,Hefei 230001,Anhui,China)
关键词:
甘油三酯葡萄糖乘积指数甘油三酯/高密度脂蛋白胆固醇比值非ST段抬高型急性冠脉综合征冠状动脉评分Gensini评分
Keywords:
Triglyceride glucose product indexTriglyceride/high density lipoprotein cholesterolratioNon-ST-segment elevation acute coronary syndromeCoronary artery scoreGensini score
分类号:
R543.3
DOI:
10.3969/j.issn.1006-1959.2023.17.016
文献标志码:
A
摘要:
目的 探讨甘油三酯葡萄糖乘积指数(TyG index)联合甘油三酯/高密度脂蛋白胆固醇比值(TG/HDL-C比值)对非ST段抬高型急性冠脉综合征(NSTE-ACS)患者冠状动脉病变严重程度的预测价值。方法 选择2021年2月-2022年3月安徽医科大学第一附属医院NSTE-ACS患者203例作为研究对象,根据患者的冠脉造影结果进行Gensini评分,以Gensini积分的中位数(QU=51)为切点,分为高危组(QU≥51,n=102)和非高危组(QU<51,n=101),比较两组临床资料、TyG指数、TG/HDL-C比值,分析TyG指数、TG/HDL-C比值与Gensini评分的相关性;使用 Logistic 回归分析TyG指数、TG/HDL-C比值与冠脉病变严重程度的相关性;使用ROC曲线评估TyG指数联合TG/HDL-C比值对冠脉病变严重程度的预测价值。结果 高危组糖尿病患者比例、HDL-C、TG、BNP、HbA1c、FBG、TyG指数及TG/HDL-C比值均高于非高危组,差异有统计学意义(P<0.05);Pearson相关分析显示,TyG指数和TG/HDL-C比值均与Gensini评分呈正相关(r=0.779、0.830);多因素二元Logistic回归分析显示,TyG指数、BNP和TG/HDL-C比值是冠脉高危病变的独立危险因素;ROC曲线分析显示,TyG指数评估冠状动脉高危病变的AUC为0.839,敏感度为72.50%,特异度为86.10%;TG/HDL-C比值评估冠状动脉高危病变的AUC为0.815,敏感度为68.60%,特异度为84.20%;TyG指数联合TG/HDL-C比值评估冠状动脉高危病变的AUC为0.845,敏感度为72.50%,特异度为85.10%。结论 TyG指数、TG/HDL-C比值均为NSTE-ACS患者冠脉病变的独立危险因素,并且具有一定的预测价值。
Abstract:
Objective To investigate the predictive value of the triglyceride glucose product index (TyG index) combined with the triglyceride/high density lipoprotein cholesterol ratio(TG/HDL-C ratio) on the severity of coronary artery lesions in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS).Methods A total of 203 patients with NSTE-ACS in the First Affiliated Hospital of Anhui Medical University from February 2021 to March 2022 were selected as the study subjects. Gensini score was performed according to the results of coronary angiography. The median of Gensini score (QU=51) was used as the cut-off point, and the patients were divided into high-risk group (QU≥51, n=102) and non-high-risk group (QU<51, n=101). The clinical data, TyG index and TG/HDL-C ratio were compared between the two groups, and the correlation between TyG index, TG/HDL-C ratio and Gensini score was analyzed. Logistic regression was used to analyze the correlation between TyG index, TG/HDL-C ratio and the severity of coronary artery disease. ROC curve was used to evaluate the predictive value of TyG index combined with TG/HDL-C ratio for the severity of coronary artery disease.Results The proportion of diabetic patients, HDL-C, TG, BNP, HbA1c, FBG, TyG index and TG/HDL-C ratio in the high-risk group were higher than those in the non-high-risk group (P<0.05). Pearson correlation analysis showed that TyG index and TG/HDL-C ratio were positively correlated with Gensini score (r=0.779,0.830). Multivariate binary Logistic regression analysis showed that TyG index, BNP and TG/HDL-C ratio were independent risk factors for high-risk coronary artery lesions. ROC curve analysis showed that the AUC of TyG index in evaluating high-risk coronary artery lesions was 0.839, the sensitivity was 72.50%, and the specificity was 86.10%; the AUC of TG/HDL-C ratio in evaluating high-risk coronary artery lesions was 0.815, the sensitivity was 68.60%, and the specificity was 84.20%; the AUC of TyG index combined with TG/HDL-C ratio in evaluating high-risk coronary artery lesions was 0.845, the sensitivity was 72.50%, and the specificity was 85.10%.Conclusion TyG index and TG/HDL-C ratio are independent risk factors for coronary artery lesions in patients with NSTE-ACS and have some predictive value.

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更新日期/Last Update: 1900-01-01