[1]黄红芳,管凌君,徐 奂.龈沟液中TIMP-1、MMP-8水平与广泛型侵袭性牙周炎患者牙槽嵴骨丢失的相关性[J].医学信息,2023,36(17):103-106.[doi:10.3969/j.issn.1006-1959.2023.17.019]
　HUANG Hong-fang,GUAN Ling-jun,XU Huan.Correlation Between the Levels of TIMP-1 and MMP-8 in Gingival Crevicular Fluid and Alveolar Bone Loss in Patients with Generalized Aggressive Periodontitis[J].Journal of Medical Information,2023,36(17):103-106.[doi:10.3969/j.issn.1006-1959.2023.17.019]
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龈沟液中TIMP-1、MMP-8水平与广泛型侵袭性牙周炎患者牙槽嵴骨丢失的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年17期
页码:
103-106
栏目:
论著
出版日期:
2023-09-01

文章信息/Info

Title:
Correlation Between the Levels of TIMP-1 and MMP-8 in Gingival Crevicular Fluid and Alveolar Bone Loss in Patients with Generalized Aggressive Periodontitis
文章编号:
1006-1959（2023）17-0103-04
作者:
黄红芳; 管凌君; 徐 奂
（广丰区人民医院口腔科，江西 上饶 334600）
Author(s):
HUANG Hong-fang; GUAN Ling-jun; XU Huan
(Stomatological Department of Guangfeng District People’s Hospital,Shangrao 334600,Jiangxi,China)
关键词:
TIMP-1; MMP-8; 广泛型侵袭性牙周炎; 牙槽嵴骨丢失
Keywords:
IMP-1; MMP-8; Generalized aggressive periodontitis; Alveolar ridge bone loss
分类号:
R781.4+2
DOI:
10.3969/j.issn.1006-1959.2023.17.019
文献标志码:
A
摘要:
目的 研究龈沟液中TIMP-1、MMP-8水平与广泛型侵袭性牙周炎患者牙槽嵴骨丢失的相关性。方法 选择2022年1月-4月在广丰区人民医院治疗的136例广泛型侵袭性牙周炎患者为研究对象，观察治疗前后患者龈沟液中MMP-8和TIMP-1水平、牙周健康指标[附着丧失（CAL）、探诊深度（PD）、出血指数（BI）、牙菌斑指数（PLI）]、牙槽嵴顶高度、牙槽嵴顶灰度值（HU），分析龈沟液中MMP-8和TIMP-1水平与以上各指标的相关性。结果 治疗3个月后，龈沟液中MMP-8低于治疗前，TIMP-1高于治疗前（P＜0.05）；治疗3个月后，患者CAL、PD、BI、PLI均低于治疗前（P＜0.05）；治疗3个月后，患者前磨牙区、磨牙区牙槽嵴顶高度大于治疗前（P＜0.05），前牙区牙槽嵴顶高度与治疗前比较，差异无统计学意义（P＞0.05）；治疗3个月后，前磨牙区、磨牙区、前牙区牙槽骨HU值均高于治疗前（P＜0.05）；龈沟液MMP-8与CAL、PD、BI、PLI、牙槽嵴顶高度、HU值无相关性（P＞0.05），TIMP-1与PLI呈负相关（P＜0.05）。结论 广泛型侵袭性牙周炎患者龈沟液TIMP-1、MMP-8水平会一定程度升高，在治疗后龈沟液TIMP-1、MMP-8水平会下降，TIMP-1、MMP-8参与疾病的发生、进展，可判断疾病预后。同时TIMP-1水平与PLI呈负相关，临床可通过检测龈沟液中TIMP-1、MMP-8水平，了解牙槽嵴骨丢失情况，避免反复检查。
Abstract:
Objective To study the correlation between the levels of TIMP-1 and MMP-8 in gingival crevicular fluid and alveolar bone loss in patients with generalized aggressive periodontitis.Methods A total of 136 patients with generalized aggressive periodontitis who were treated in Guangfeng District People’s Hospital from January to April 2022 were selected as the study subjects. The levels of MMP-8 and TIMP-1 in gingival crevicular fluid, periodontal health indicators [clinical attachment level (CAL), probing depth (PD), bleeding index (BI), plaque index (PLI)], alveolar crest height, and alveolar crest gray value (HU) were observed before and after treatment. The correlation between MMP-8 and TIMP-1 levels in gingival crevicular fluid and the above indicators was analyzed.Results After 3 months of treatment, MMP-8 in gingival crevicular fluid was lower than that before treatment, and TIMP-1 was higher than that before treatment (P<0.05). After 3 months of treatment, the CAL, PD, BI and PLI of patients were lower than those before treatment (P<0.05). After 3 months of treatment, the height of alveolar crest in premolar area and molar area was higher than that before treatment (P<0.05), and there was no significant difference in the height of alveolar crest in anterior teeth area compared with that before treatment (P>0.05). After 3 months of treatment, the HU values of alveolar bone in premolar area, molar area and anterior teeth area were higher than those before treatment (P<0.05), and TIMP-1 was negatively correlated with PLI (P<0.05).Conclusion The levels of TIMP-1 and MMP-8 in gingival crevicular fluid of patients with generalized aggressive periodontitis will increase to a certain extent. After treatment, the levels of TIMP-1 and MMP-8 in gingival crevicular fluid will decrease. TIMP-1 and MMP-8 are involved in the occurrence and progression of the disease, which can judge the prognosis of the disease. At the same time, the level of TIMP-1 was negatively correlated with PLI. Clinically, the levels of TIMP-1 and MMP-8 in gingival crevicular fluid can be detected to understand the loss of alveolar bone and avoid repeated examination.

参考文献/References:

[1]陈洁,夏凤君,王慧.广泛型侵袭性牙周炎患者治疗期间牙齿缺失和牙槽嵴骨丢失情况分析[J]. 口腔医学研究,2019,35(9):846-849. [2]朱亚桥,陈丽娟,刘一.广泛型侵袭性牙周炎的牙周基础治疗长期疗效观察[J].临床口腔医学杂志,2019,35(7):418-421. [3]刘建,王宪娥,吕达,等.广泛型侵袭性牙周炎患者牙根形态异常与相关致病基因的关联[J].北京大学学报,2021,53(1):16-23. [4]孙晓娟,许春姣,池毓坦,等.广泛型侵袭性牙周炎基础治疗前后牙槽骨变化的CBCT评价[J].牙体牙髓牙周病学杂志,2017,9(11):638-643.[5]孙俊毅,汪明敏,董凯,等.牙周炎患牙位点保存术的临床疗效观察[J].西安交通大学学报,2018,37(3):437-440.[6]王晖,蒋勇.CBCT在评价慢性牙周炎牙周基础治疗前后牙槽骨变化的应用研究[J].口腔医学,2017,37(5):444-448.[7]徐倩,杨佳佳,刘志华,等.低氧和牙周炎对牙周组织中HIF-1a和MMP2表达的影响[J].第三军医大学学报,2017,39(7):616-621.[8]张海亮,苏智勇,裴 玉 岩,等.甲硝唑联合羟氨苄青霉素对侵袭性牙周炎患者龈沟液中MMP-1、MMP-2和TIMP-1水平的影响[J].实用口腔医学杂志,2016,32(2):285-288.[9]詹暶,林燕,陈梅芳,等.牙周非手术治疗对重度慢性牙周炎患者龈沟液中MMP-8和TIMP-1水平的影响[J].福建医科大学学报,2017,11(6):365-368.[10]高颖,郝晨笛.慢性牙周炎患者唾液中miR-146a的表达及其与龈沟炎症、MMP-8/TIMP-1水平的关系[J].上海口腔医学,2018,27(3):309-312. [11]郑琼琪,王淑芳,金煌.治疗依从性与慢性牙周炎患者IL-16、MMP-8和TIMP-1水平、基础治疗疗效的关系[J].国际检验医学杂志,2018,39(15):1849-1852. [12]孙欣彤,郭莹,曹洁,等.慢性牙周炎患者β-catenin,MMP-8表达情况及与病情严重程度的相关性分析[J].川北医学院学报,2020,35(2):227-231. [13]龚攀,曾玉,邝燕好,等.龈沟液中Shh蛋白、MMP-8与老年慢性牙周炎患者炎症程度的相关性[J].中国老年学杂志,2020,40(16):3478-3481. [14]徐玉丽,冉明,杨星民.拔牙后不同移植材料牙槽窝保存术对牙槽骨吸收的影响[J].口腔颌面外科杂志,2020,30(1):23-27.[15]张晓莉,马嘉平.神经调节蛋白4及其受体ErbB4在牙周炎患者龈沟液中的表达及对牙周炎大鼠牙周组织炎症和牙槽骨丢失的影响[J].徐州医科大学学报,2022,42(5):318-325.[16]王玉玲.光动力疗法辅助非手术治疗对慢性牙周炎患者龈沟液MMP-8、TNF-α和TIMP-1水平的影响[J].广西医科大学学报,2019,30(8):125-128.[17]Tolstunov L,Hamrick JFE,Broumand V,et al.Bone Augmentation Techniques for Horizontal and Vertical Alveolar Ridge Deficiency in Oral Implantology[J].Oral Maxillofac Surg Clin North Am,2019,31(2):163-191. [18]张丽薇.吸烟对慢性牙周炎患者龈沟液中MMP-8、TIMP-1表达影响的研究[D].佳木斯:佳木斯大学,2018.[19]康建颖.正畸与牙周联合治疗牙周炎对MMP-8与TIMP-1的影响[J].河南医学高等专科学校学报,2017,12(15):139-141.[20]詹暶,林燕,陈梅芳,等.牙周非手术治疗对重度慢性牙周炎患者龈沟液中MMP-8和TIMP-1水平的影响[J].福建医科大学学报,2018,28(15):103-105.

更新日期/Last Update: 1900-01-01