[1]彭 蘡,黄 婷,徐 燕.载脂蛋白E、三酰甘油、LDL-C及联合检测在早期动脉粥样硬化性脑梗死患者中的应用价值[J].医学信息,2023,36(20):99-102.[doi:10.3969/j.issn.1006-1959.2023.20.018]
 PENG Ying,HUANG Ting,XU Yan.Application Value of Apolipoprotein E, Triglyceride, LDL-C and Combined Detection in Patients with Early Atherosclerotic Cerebral Infarction[J].Journal of Medical Information,2023,36(20):99-102.[doi:10.3969/j.issn.1006-1959.2023.20.018]
点击复制

载脂蛋白E、三酰甘油、LDL-C及联合检测在早期动脉粥样硬化性脑梗死患者中的应用价值()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年20期
页码:
99-102
栏目:
论著
出版日期:
2023-10-15

文章信息/Info

Title:
Application Value of Apolipoprotein E, Triglyceride, LDL-C and Combined Detection in Patients with Early Atherosclerotic Cerebral Infarction
文章编号:
1006-1959(2023)20-0099-04
作者:
彭 蘡黄 婷徐 燕
(溧阳市人民医院检验科,江苏 溧阳 213300)
Author(s):
PENG YingHUANG TingXU Yan
(Department of Clinical Laboratory,Liyang People ’s Hospital,Liyang 213300,Jiangsu,China)
关键词:
早期动脉粥样硬化性脑梗死载脂蛋白E三酰甘油低密度脂蛋白胆固醇
Keywords:
Early atherosclerotic cerebral infarctionApolipoprotein ETriacylglycerolLow-density lipoprotein cholesterol
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2023.20.018
文献标志码:
A
摘要:
目的 研究载脂蛋白E(ApoE)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)及联合检测在早期动脉粥样硬化性脑梗死(ACI)患者中的应用价值。方法 将2021年7月-2022年9月溧阳市人民医院收治的107例早期ACI患者设为ACI组,同期收集107例健康体检者设为健康组,比较两组血清ApoE、TG和LDL-C的表达水平,并对三项指标的阳性检出率及诊断价值进行分析。结果 ACI组ApoE、TG、LDL-C表达水平均高于健康组(P<0.05),且ACI组三项指标单独及联合检测的阳性检出率均高于健康组(P<0.05);经受试者工作特征曲线分析显示,三项指标单独及联合检测对早期诊断ACI均存在价值,且三项指标中ApoE对应的曲线下面积最大(AUC=0.768),诊断灵敏度和特异度分别为87.90%和57.90%,三项联合对应的AUC为0.775,与ApoE相比并无升高。结论 ApoE、TG、LDL-C单独及联合检测均对ACI有潜在早期诊断价值,其中ApoE单独检测的意义更为明显。
Abstract:
Objective To study the application value of apolipoprotein E (ApoE), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C) and their combined detection in patients with early atherosclerotic cerebral infarction (ACI).Methods A total of 107 patients with early ACI admitted to Liyang People’s Hospital from July 2021 to September 2022 were set as ACI group, and 107 healthy subjects were collected as healthy group. The expression levels of serum ApoE, TG and LDL-C were compared between the two groups, and the positive detection rate and diagnostic value of the three indicators were analyzed.Results The expression levels of ApoE, TG and LDL-C in ACI group were higher than those in healthy group (P<0.05), and the positive detection rates of the three indexes in ACI group were higher than those in the healthy group (P<0.05). The receiver operating characteristic curve analysis showed that the three indicators alone and combined detection had value in the early diagnosis of ACI, among the three indicators, the area under the curve corresponding to ApoE was the largest (AUC=0.768), the diagnostic sensitivity and specificity were 87.90% and 57.90% respectively, and the AUC corresponding to the combination of the three indicators was 0.775, which was not obviously higher than that of ApoE.Conclusion ApoE, TG, LDL-C alone and combined detection have potential early diagnostic value for ACI, and the significance of ApoE alone is more obvious.

参考文献/References:

[1]解吉雄,王锐,戴颖,等.巨细胞病毒及肺炎支原体感染和载脂蛋白E基因多态性与脑梗死患者颈动脉粥样硬化的关联[J].中华医院感染学杂志,2022,32(11):1673-1677.[2]Li Y,Zhong Z,Luo S,et al.Efficacy of Antihypertensive Therapy in the Acute Stage of Cerebral Infarction - A Prospective, Randomized Control Trial[J].Acta Cardiol Sin,2018,34(6):502-510.[3]Zhao X,Zhao M,Pang B,et al.Diagnostic value of combined serological markers in the detection of acute cerebral infarction[J].Medicine (Baltimore),2021,100(36):e27146.[4]边素艳,王艳丽,刘宏斌.动脉粥样硬化性心血管病危险分层患者SLCO1B1和载脂蛋白E基因多态性与血脂的关系[J].中华老年心脑血管病杂志,2018,20(7):676-680.[5]李欣灿,崔虎.血清LP(a)、LDL-C、Hcy和Cys C与急性脑梗死的相关性及诊断价值的研究[J].蚌埠医学院学报,2021,46(5):630-634.[6]郭笑颜,陈伟彬,李盖,等.脑梗死患者血脂水平与颈动脉粥样硬化CTA特征的相关性[J].临床放射学杂志,2019,38(2):214-218.[7]Chang JJ,Katsanos AH,Khorchid Y,et al.Higher low-density lipoprotein cholesterol levels are associated with decreased mortality in patients with intracerebral hemorrhage[J].Atherosclerosis,2018,269:14-20.[8]王静,刘旭,王冥思,等.探讨载脂蛋白E和超敏C反应蛋白与冠心病的相关性[J].标记免疫分析与临床,2021,28(11):1848-1850.[9]Centa M,Prokopec KE,Garimella MG,et al.Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis[J].Arterioscler Thromb Vasc Biol,2018,38(8):e145-e158.[10]中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.缺血性卒中基层诊疗指南(2021年)[J].中华全科医师杂志,2021,20(9):927-946.[11]何平.脑梗死患者血脂、载脂蛋白、血尿酸水平的变化及其临床价值探讨[J].中国实验诊断学,2019,23(6):1038-1040.[12]匡静,冯婷,刘莉.血清半胱氨酸、载脂蛋白、纤维蛋白原水平变化对脑梗死患者病情的影响[J].实用医院临床杂志,2021,18(1):148-151.[13]吴强,吕晓影,张乐国.血浆脂蛋白相关磷脂酶A2、超敏C反应蛋白联合载脂蛋白E检测在脑梗死诊断中的应用价值[J].中南医学科学杂志,2019,47(1):40-43.[14]刘淑静,常欣魁,陈柯霖,等.载脂蛋白E基因多态性与脑梗患者年龄和血脂的相关性研究[J].标记免疫分析与临床,2018,25(11):1595-1598.[15]孙文静,黄流清,周菲,等.载脂蛋白B联合低密度脂蛋白胆固醇检测预测急性脑梗死的价值[J].实用临床医药杂志,2018,22(21):102-103,106.[16]张晓愉,栾少群,张涛,等.甘油三酯、尿蛋白、氧化低密度脂蛋白对急性腔隙性脑梗死临床分析[J].内蒙古医科大学学报,2019,41(1):63-66.[17]Gerdes C,Fisher RM,Nicaud V,et al.Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies[J].Circulation,1997,96(3):733-740.[18]卫晓红,宋艳玲.血浆同型半胱氨酸、C反应蛋白和低密度脂蛋白-胆固醇水平与脑梗死患者颅内动脉、颅外动脉狭窄相关性分析[J].陕西医学杂志,2019,48(10):1366-1368,1373.[19]Gao S,Zhao D,Qi Y,et al.Circulating Oxidized Low-Density Lipoprotein Levels Independently Predict 10-Year Progression of Subclinical Carotid Atherosclerosis: A Community-Based Cohort Study[J].J Atheroscler Thromb,2018,25(10):1032-1043.[20]Shim J,Poulsen CB,Hagensen MK,et al.Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs[J].JACC Basic Transl Sci,2017,2(5):591-600.[21]凌启节.血清LP(a)、ApoE水平与大动脉粥样硬化型脑梗死的关系[J].皖南医学院学报,2017,36(6):552-554.

相似文献/References:

[1]王寿梅,宋 媛,王敏佳,等.载脂蛋白E与不同卒中亚型关系的研究进展[J].医学信息,2024,37(17):177.[doi:10.3969/j.issn.1006-1959.2024.17.040]
 WANG Shou-mei,SONG Yuan,WANG Min-jia,et al.Research Progress on the Relationship Between Apolipoprotein E and Different Stroke Subtypes[J].Journal of Medical Information,2024,37(20):177.[doi:10.3969/j.issn.1006-1959.2024.17.040]

更新日期/Last Update: 1900-01-01