[1]谭子跃.干扰素合并恩替卡韦治疗乙型病毒性肝炎患者的疗效及对患者肝功能的影响[J].医学信息,2023,36(20):137-140.[doi:10.3969/j.issn.1006-1959.2023.20.027]
　TAN Zi-yue.Effect of Interferon Combined with Entecavir in the Treatment of Patients with Hepatitis B and its Effect on Liver Function[J].Journal of Medical Information,2023,36(20):137-140.[doi:10.3969/j.issn.1006-1959.2023.20.027]
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干扰素合并恩替卡韦治疗乙型病毒性肝炎患者的疗效及对患者肝功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年20期
页码:
137-140
栏目:
论著
出版日期:
2023-10-15

文章信息/Info

Title:
Effect of Interferon Combined with Entecavir in the Treatment of Patients with Hepatitis B and its Effect on Liver Function
文章编号:
1006-1959（2023）20-0137-04
作者:
谭子跃
（余干县人民医院门诊二楼，江西 余干 335100）
Author(s):
TAN Zi-yue
(The Second Floor of the Outpatient Department of Yugan County People’s Hospital,Yugan 335100,Jiangxi,China)
关键词:
干扰素; 恩替卡韦; 乙型病毒性肝炎; 肝功能
Keywords:
Interferon; Entecavir; Hepatitis B; Liver function
分类号:
R575.1
DOI:
10.3969/j.issn.1006-1959.2023.20.027
文献标志码:
A
摘要:
目的 研究干扰素合并恩替卡韦治疗乙型病毒性肝炎患者的疗效及对肝功能的影响。方法 选取2020年1月-2022年9月在我院诊治的58例乙型病毒性肝炎患者为研究对象，采用随机数字表法分为对照组（n=29）和观察组（n=29），对照组采用恩替卡韦治疗，观察组在对照组基础上给予干扰素治疗，比较两组临床疗效、乙肝病毒基因（HBV－DNA）转阴率、肝功能指标［谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）]、并发症发生率、生活质量水平及不良反应发生率。结果 观察组治疗总有效率（93.10%）高于对照组（79.31%）（P＜0.05）；观察组HBV－DNA转阴率（75.86%）高于对照组（51.72%）（P＜0.05）；两组治疗后ALT、AST均低于治疗前，TBIL均高于治疗前，且观察组ALT、AST低于对照组，TBIL高于对照组（P＜0.05）；观察组并发症发生率为10.34%，低于对照组的24.14%（P＜0.05）；两组治疗后生活质量水平高于治疗前，且观察组高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 干扰素合并恩替卡韦治疗乙型病毒性肝炎具有确切的疗效，可提高治疗效果，改善肝功能，提升HBV-DNA转阴率，降低并发症发生率，且无严重不良反应，具有良好的有效性、安全性，值得临床应用。
Abstract:
Objective To study the efficacy of interferon combined with entecavir in the treatment of patients with hepatitis B and its effect on liver function.Methods A total of 58 patients with hepatitis B diagnosed and treated in our hospital from January 2020 to September 2022 were selected as the research objects. They were divided into control group (n=29) and observation group (n=29) by random number table method. The control group was treated with entecavir, and the observation group was treated with interferon on the basis of the control group. The clinical efficacy, negative conversion rate of hepatitis B virus gene (HBV-DNA), liver function indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL)], incidence of complications, quality of life level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group (93.10%) was higher than that in the control group (79.31%) (P<0.05). The negative conversion rate of HBV-DNA in the observation group (75.86%) was higher than that in the control group (51.72%) (P<0.05). After treatment, ALT and AST in the two groups were lower than those before treatment, TBIL was higher than that before treatment, and ALT and AST in the observation group were lower than those in the control group, TBIL was higher than that in the control group (P<0.05). The incidence of complications in the observation group was 10.34 %, which was lower than 24.14 % in the control group (P<0.05). The quality of life of the two groups after treatment was higher than that before treatment, and that of the observation group was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Interferon combined with entecavir has a definite effect in the treatment of viral hepatitis B, which can improve the therapeutic effect, improve liver function, increase HBV-DNA negative conversion rate, reduce the incidence of complications, and has no serious adverse reactions. It has good efficacy and safety and is worthy of clinical application.

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更新日期/Last Update: 1900-01-01