[1]陈 甜,付朝霞.中性粒细胞明胶酶相关脂质运载蛋白对早期糖尿病肾病的诊断价值[J].医学信息,2023,36(23):95-98.[doi:10.3969/j.issn.1006-1959.2023.23.024]
　CHEN Tian,FU Zhao-xia.Diagnostic Value of Neutrophil Gelatinase-associated Lipocalin in Early-stage Diabetic Nephropathy[J].Journal of Medical Information,2023,36(23):95-98.[doi:10.3969/j.issn.1006-1959.2023.23.024]
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中性粒细胞明胶酶相关脂质运载蛋白对早期糖尿病肾病的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
95-98
栏目:
论著
出版日期:
2023-12-01

文章信息/Info

Title:
Diagnostic Value of Neutrophil Gelatinase-associated Lipocalin in Early-stage Diabetic Nephropathy
文章编号:
1006-1959（2023）23-0095-04
作者:
陈 甜; 付朝霞
（高安市人民医院检验科，江西 高安 330800）
Author(s):
CHEN Tian; FU Zhao-xia
(Laboratory of Gao’an People’s Hospital,Gao’an 330800,Jiangxi,China)
关键词:
早期糖尿病肾病; 中性粒细胞明胶酶相关脂质运载蛋白; 肾小球滤过率; 尿白蛋白/肌酐比值; 肾损伤
Keywords:
Earlystage diabetes nephropathy; Neutrophil gelatinase associated lipid transporter protein; Glomerular filtration rate; Urinary albumin/creatinine ratio; Renal injury
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2023.23.024
文献标志码:
A
摘要:
目的 研究中性粒细胞明胶酶相关脂质运载蛋白（NGAL）对早期糖尿病肾病（DN）的诊断价值。方法 将2020年1月-2023年1月高安市人民医院收治的82例早期DN患者设为DN组，另取同期就诊的50例单纯糖尿病患者设为DM组，检测两组患者的NGAL水平、尿白蛋白/肌酐比值（UACR）、肾小球滤过率（eGFR）指标，分析NGAL指标对早期DN的诊断价值，另比较不同肾损伤分级患者的NGAL、UACR、eGFR水平，采用Spearman相关性分析NGAL水平与UACR、eGFR的关系。结果 DN组NGAL、UACR水平高于DM组，eGFR水平低于DM组（P＜0.05）。经ROC曲线分析显示，NGAL检测对早期DN疾病具有确切诊断价值，其AUC值为0.836，敏感性为90.14%，特异性为87.62%，约登指数为0.875，95%CI区间为0.682~0.914。不同肾损伤分级患者的NGAL、UACR、eGFR水平比较，差异有统计学意义（P＜0.05），其中NGAL、UACR指标由高至低依次为Ⅲ期＞Ⅱ期＞Ⅰ期，eGFR指标由高至低依次为Ⅰ期＞Ⅱ期＞Ⅲ期。Spearman相关性分析显示，DN患者的NGAL水平与UACR呈正相关（r=0.502，P=0.000），与eGFR呈负相关（r=-0.473，P=0.000）。结论 NGAL指标对早期DN疾病具有良好诊断价值，其参数水平与患者肾损伤程度密切相关。
Abstract:
Objective To study the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in early-stage diabetic nephropathy (DN).Methods A total of 82 patients with early-stage DN admitted to Gao’an People’s Hospital from January 2020 to January 2023 were set as DN group, and 50 patients with simple diabetes were set as DM group. The NGAL level, urinary albumin/creatinine ratio (UACR) and glomerular filtration rate (eGFR) of the two groups were detected, and the diagnostic value of NGAL index for early DN was analyzed. The levels of NGAL, UACR and eGFR in patients with different renal injury grades were compared. Spearman correlation was used to analyze the relationship between NGAL level and UACR and eGFR.Results The levels of NGAL and UACR in DN group were higher than those in DM group, and the level of eGFR was lower than that in DM group (P<0.05). ROC curve analysis showed that NGAL detection had a definite diagnostic value for early DN disease. The AUC value was 0.836, the sensitivity was 90.14%, the specificity was 87.62%, the Youden index was 0.875, and the 95%CI interval was 0.682-0.914. The levels of NGAL, UACR and eGFR in patients with different renal injury grades were statistically significant (P<0.05). The NGAL and UACR indexes from high to low were stage Ⅲ> stage Ⅱ> stage Ⅰ, and the eGFR indexes from high to low were stage Ⅰ> stage Ⅱ> stage Ⅲ. Spearman correlation analysis showed that NGAL level in DN patients was positively correlated with UACR (r=0.502, P=0.000) and negatively correlated with eGFR (r=-0.473, P=0.000).Conclusion NGAL index has good diagnostic value for early DN disease, and its parameter level is closely related to the degree of renal injury in patients.

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更新日期/Last Update: 1900-01-01