[1]李文婷.复方丹参滴丸联合羟苯磺酸钙治疗糖尿病视网膜病变的效果[J].医学信息,2023,36(24):117-120.[doi:10.3969/j.issn.1006-1959.2023.24.026]
　LI Wen-ting.Effect of Compound Danshen Dripping Pills Combined with Calcium Dobesilate in the Treatment of Diabetic Retinopathy[J].Journal of Medical Information,2023,36(24):117-120.[doi:10.3969/j.issn.1006-1959.2023.24.026]
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复方丹参滴丸联合羟苯磺酸钙治疗糖尿病视网膜病变的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年24期
页码:
117-120
栏目:
中医中药
出版日期:
2023-12-15

文章信息/Info

Title:
Effect of Compound Danshen Dripping Pills Combined with Calcium Dobesilate in the Treatment of Diabetic Retinopathy
文章编号:
1006-1959（2023）24-0117-04
作者:
李文婷
（天津市第二医院内分泌科，天津 300000）
Author(s):
LI Wen-ting
(Department of Endocrinology,Tianjin Second Hospital,Tianjin 300000,China)
关键词:
复方丹参滴丸; 羟苯磺酸钙; 糖尿病视网膜病变; 血糖
Keywords:
Compound Danshen dropping pills; Calcium dobesilate; Diabetic retinopathy; Blood glucose
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2023.24.026
文献标志码:
A
摘要:
目的 观察复方丹参滴丸联合羟苯磺酸钙治疗糖尿病视网膜病变的效果。方法 选取2020年2月-2022年2月我院诊治的120例糖尿病视网膜病变患者为研究对象，采用随机数字表法分为对照组和观察组，各组60例。对照组采用羟苯磺酸钙治疗，观察组在对照组基础上给予复方丹参滴丸治疗，比较两组临床效果、血糖指标、视力改善情况、眼部症状（视野灰度值、血管瘤体积、黄斑厚度、出血斑面积）以及不良反应发生率。结果 观察组治疗总有效率为96.67%，高于对照组的83.33%（P＜0.05）；两组治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白水平均低于治疗前，且观察组低于对照组（P＜0.05）；观察组视力＞1.0占比大于对照组（P＜0.05），而视力0.7~1.0、0.4~0.6、≤0.4占比与对照组比较，差异无统计学意义（P＞0.05）；两组治疗后视野灰度值、血管瘤体积、黄斑厚度、出血斑面积均小于治疗前，且观察组小于对照组（P＜0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）。结论 复方丹参滴丸联合羟苯磺酸钙治疗糖尿病视网膜病变的效果确切，可改善视网膜症状，提升视力水平，降低血糖水平，且不增加不良反应发生几率。
Abstract:
Objective To observe the effect of compound Danshen dripping pills combined with calcium dobesilate in the treatment of diabetic retinopathy.Methods A total of 120 patients with diabetic retinopathy diagnosed and treated in our hospital from February 2020 to February 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 60 patients in each group. The control group was treated with calcium dobesilate, and the observation group was treated with compound Danshen dripping pills on the basis of the control group. The clinical effect, blood glucose index, visual acuity improvement, ocular symptoms (visual field gray value, hemangioma volume, macular thickness, bleeding spot area) and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%, which was higher than 83.33% in the control group (P<0.05). After treatment, the levels of fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The proportion of visual acuity >1.0 in the observation group was greater than that in the control group (P<0.05), while there was no significant difference in the proportion of visual acuity 0.7-1.0, 0.4-0.6, ≤0.4 between the observation group and the control group (P>0.05). After treatment, the gray value of visual field, hemangioma volume, macular thickness and hemorrhage area in the two groups were smaller than those before treatment, and those in the observation group were smaller than the control group (P<0.05).Conclusion Compound Danshen dripping pills combined with calcium dobesilate is effective in the treatment of diabetic retinopathy, which can improve retinal symptoms, improve visual acuity, reduce blood glucose levels, and does not increase the incidence of adverse reactions.

参考文献/References:

[1]赵朵.羟苯磺酸钙胶囊辅助治疗糖尿病视网膜病变患者的疗效及对其血液流变学、血管内皮功能与凝血酶影响分析[J].实用糖尿病杂志,2019,15(6):57-58.[2]阮余霞,陈明,刘志谦,等.口服复方丹参滴丸联合羟苯磺酸钙糖尿病肾病患者视网膜病变的临床研究[J].中南医学科学杂志,2017,45(1):18-20,23.[3]汤敏,史小英,王维萍,等.阿托伐他汀联合复方丹参滴丸治疗DR伴高血脂的临床研究[J].西南国防医药,2018,28(2):143-146.[4]朱振涛.眼底激光联合羟苯磺酸钙治疗糖尿病视网膜病变[J].国际眼科杂志,2017,17(2):288-290.[5]陈利荣,姚军平,张贻转,等.羟苯磺酸钙联合GLP-1类似物治疗糖尿病视网膜病变的临床意义[J].中国医院药学杂志,2017,37(15):1505-1508.[6]郭硕,王伟.疏血通注射液联合羟苯磺酸钙胶囊治疗单纯型糖尿病视网膜病变的疗效观察[J].现代药物与临床,2016,31(6):819-822.[7]马梦瑾,田晨光,赵志刚,等.复方丹参滴丸治疗早期糖尿病视网膜病变的疗效[J].世界中医药,2016,11(3):450-453.[8]胡小莉,李曼红,车红芳.复方丹参滴丸、明目地黄丸、羟苯磺酸钙联合治疗Ⅲ期糖尿病性视网膜病变的效果观察[J].实用临床医药杂志,2019,23(19):96-99.[9]李会会,姜涛,文祯.羟苯磺酸钙辅助治疗对老年2型糖尿病合并视网膜病变患者血清D-二聚体、同型半胱氨酸及C反应蛋白水平的影响[J].中国老年学杂志,2016,36(18):4488-4490.[10]贾姗姗.康柏西普治疗重度非增殖性糖尿病视网膜病伴黄斑水肿脉络膜厚度的变化[D].大连:大连医科大学,2019.[11]曹霞.芪明颗粒联合羟苯磺酸钙胶囊治疗非增殖期糖尿病视网膜病变患者脉络膜循环及干眼症的疗效[J].临床合理用药,2023,16(8):113-116.[12]叶秀玲,郭晓娜,熊飞.口服羟苯磺酸钙联合和血明目片治疗非增殖性糖尿病视网膜病变临床观察[J].川北医学院学报,2019,34(2):223-225.[13]高立,祁涛,许文彬,等.和血明目片联合羟苯磺酸钙治疗早期糖尿病视网膜病变临床研究[J].中国药业,2020,29(10):133-135.[14]高清垚,郑睿.复方丹参滴丸联合激光光凝多点扫描治疗糖尿病视网膜病变的临床效果[J].世界中医药,2019,14(4):907-910.[15]王妙然,李秋艳,马学竹,等.基于网络药理学的复方丹参滴丸治疗糖尿病视网膜病变的作用机制研究[J].中国中医眼科杂志,2020,30(4):293-302.[16]孙晓艳.益气养阴通络中药复方治疗非增殖期糖尿病视网膜病变的疗效和对PDGF影响的研究[D].南京:南京中医药大学,2023.[17]颜卫星,陆骏麒,彭志佳,等.复方丹参滴丸联合羟苯磺酸钙胶囊治疗糖尿病视网膜病变的临床疗效[J].内蒙古中医药,2022,41(9):40-42.[18]张敏芝,高丰.血府逐瘀汤加减治疗糖尿病视网膜病变Ⅳ期疗效及对患者视力水平、生活质量的影响[J].陕西中医,2022,43(10):1400-1403.[19]蔡凤群,马会杰.芪药益气生津丸治疗糖尿病视网膜病变的效果分析[J].中医临床研究,2022,14(23):75-77.[20]谢红,骆艺,张景,等.复方血栓通胶囊联合康柏西普治疗糖尿病视网膜病变的临床研究[J].现代药物与临床,2022,37(7):1560-1564.

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更新日期/Last Update: 1900-01-01