[1]莫燕婷.丙泊酚中长链脂肪乳静脉麻醉对老年骨折患者的疗效及安全性[J].医学信息,2024,37(02):103-106.[doi:10.3969/j.issn.1006-1959.2024.02.019]
　MO Yan-ting.Efficacy and Safety of Medium/long-chain Triglyceride Emulsion of Propofol in the Intravenous Anesthesia of Elderly Patients with Fracture[J].Journal of Medical Information,2024,37(02):103-106.[doi:10.3969/j.issn.1006-1959.2024.02.019]
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丙泊酚中长链脂肪乳静脉麻醉对老年骨折患者的疗效及安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年02期
页码:
103-106
栏目:
论著
出版日期:
2024-01-15

文章信息/Info

Title:
Efficacy and Safety of Medium/long-chain Triglyceride Emulsion of Propofol in the Intravenous Anesthesia of Elderly Patients with Fracture
文章编号:
1006-1959（2024）02-0103-04
作者:
莫燕婷
（九江市第一人民医院药剂科，江西 九江 332000）
Author(s):
MO Yan-ting
(Pharmacy Department of Jiujiang First People’s Hospital,Jiujiang 332000,Jiangxi,China)
关键词:
丙泊酚中长链脂肪乳; 静脉麻醉; 老年骨折; 痛觉阻滞时间
Keywords:
Medium/long-chain triglyceride emulsion of propofol; Intravenous anesthesia; Senile fracture; Pain retention time
分类号:
R614
DOI:
10.3969/j.issn.1006-1959.2024.02.019
文献标志码:
A
摘要:
目的 观察丙泊酚中长链脂肪乳静脉麻醉对老年骨折患者的临床疗效及安全性。方法 选取2020年5月-2022年5月在我院诊治的66例老年骨折患者为研究对象，采用随机数字表法分为对照组和观察组，每组33例。对照组采用丙泊酚长链脂肪乳静脉麻醉，观察组采用丙泊酚中长链脂肪乳静脉麻醉。比较两组注射疼痛率、疼痛评分、不同时间点血流动力学指标[心率（HR）、平均动脉压（MAP）]、血清内皮素（ET）和降钙素基因相关肽（CGRP）浓度、痛觉阻滞起效和持续时间以及不良反应发生率。结果 观察组注射疼痛率、疼痛评分均小于对照组（P＜0.05）；两组麻醉诱导前HR、MAP比较，差异无统计学意义（P＞0.05），两组插管后HR、MAP均降低，但观察组高于对照组（P＜0.05）；两组插管后ET下降，CGRP升高，但观察组ET、CGRP均低于对照组（P＜0.05）；观察组痛觉阻滞起效时间短于对照组，痛觉持续时间长于对照组（P＜0.05）；观察组不良反应发生率为9.09%，低于对照组的21.21%（P＜0.05）。结论 丙泊酚中长链脂肪乳静脉麻醉在老年骨折患者中具有良好的效果，可提升麻醉效果，减轻注射痛，降低注射疼痛率，对患者血流动力学指标的影响小，可调节血浆CGRP和ET浓度，缩短痛觉阻滞起效时间，延长痛觉阻滞持续时间，且不良反应发生率低，安全性良好。
Abstract:
Objective To observe the clinical efficacy and safety of medium/long-chain triglyceride emulsion of propofol in the intravenous anesthesia of elderly patients with fracture.Methods A total of 66 elderly patients with fracture who were diagnosed and treated in our hospital from May 2020 to May 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 33 patients in each group. The control group was treated with long-chain triglyceride emulsion of propofol for intravenous anesthesia, and the observation group was treated with medium/long-chain triglyceride emulsion of propofol for intravenous anesthesia. The injection pain rate, pain score, hemodynamic indexes [heart rate (HR), mean arterial pressure (MAP)] at different time points, serum endothelin (ET) and calcitonin gene-related peptide (CGRP) concentrations, onset and duration of pain retention time, and incidence of adverse reactions were compared between the two groups.Results The injection pain rate and pain score of the observation group were lower than those of the control group (P<0.05). There was no significant difference in HR and MAP between the two groups before anesthesia induction (P>0.05), while the HR and MAP of the two groups decreased after intubation, but the observation group was higher than the control group (P<0.05). After intubation, ET decreased and CGRP increased in the two groups, but ET and CGRP in the observation group were lower than those in the control group (P<0.05). The onset time of pain in the observation group was shorter than that in the control group, and the duration of pain was longer than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was 9.09%, which was lower than 21.21% in the control group (P<0.05).Conclusion Medium/long-chain triglyceride emulsion of propofol for intravenous anesthesia has a good effect in elderly patients with fracture, which can improve the anesthetic effect, reduce the injection pain, reduce the injection pain rate, and has little effect on the hemodynamic indexes of patients. Meanwhile, it can regulate the concentration of plasma CGRP and ET, shorten the onset time of pain block, prolong the duration of pain block, and has low incidence of adverse reactions and good safety.

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更新日期/Last Update: 1900-01-01