[1]何琛琛,高 媛,张明霞,等.初诊双相障碍Ⅱ型抑郁发作患者认知功能改变及与临床特征的关系研究[J].医学信息,2024,37(11):74-78.[doi:10.3969/j.issn.1006-1959.2024.11.013]
　HE Chen-chen,GAO Yuan,ZHANG Ming-xia,et al.Study on the Changes of Cognitive Function and its Relationship with Clinical Characteristics in Patients with Newly Diagnosed Bipolar Disorder Type Ⅱ Depressive Episode[J].Journal of Medical Information,2024,37(11):74-78.[doi:10.3969/j.issn.1006-1959.2024.11.013]
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初诊双相障碍Ⅱ型抑郁发作患者认知功能改变及与临床特征的关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年11期
页码:
74-78
栏目:
论著
出版日期:
2024-06-01

文章信息/Info

Title:
Study on the Changes of Cognitive Function and its Relationship with Clinical Characteristics in Patients with Newly Diagnosed Bipolar Disorder Type Ⅱ Depressive Episode
文章编号:
1006-1959（2024）11-0074-05
作者:
何琛琛; 高 媛; 张明霞; 等
（国药东风茅箭医院/十堰市精神病医院精神科，湖北 十堰 442012）
Author(s):
HE Chen-chen; GAO Yuan; ZHANG Ming-xia; et al.
(Department of Psychiatry,Sinopharm Dongfeng Maojian Hospital/Shiyan Mental Hospital,Shiyan 442012,Hubei,China)
关键词:
双相情感障碍; 抑郁发作; 认知功能; 临床特征
Keywords:
Bipolar disorder; Depressive episode; Cognitive function; Clinical characteristics
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2024.11.013
文献标志码:
A
摘要:
目的 探讨初诊双相障碍Ⅱ型抑郁发作患者认知功能改变及与临床特征的关系。方法 纳入2018年1月-2021年1月我院就诊初诊双相障碍Ⅱ型抑郁发作患者，以及同期招募的我院体检中心完善检查的健康人群各172例。比较两组一般资料、临床特征、精神分裂症认知功能评估成套测验认知功能评分（MCCB）及认知功能损伤发生率，并进一步评价患者临床症状与认知功能间相关性。结果 两组性别、年龄及受教育年限比较，差异无统计学意义（P＞0.05）；观察组 HAMD24量表总分高于对照组（P＜0.05）；观察组信息处理评分、注意力警觉评分、工作记忆评分、词语学习评分、视觉学习评分、推理与问题解决评分、社会认知评分及MCCB量表总分低于对照组（P＜0.05）；观察组低于1个、1.5个及2个标准差MCCB量表评分比例均高于对照组（P＜0.05）；相关性分析结果显示，患者词语学习能力、推理与问题解决能力评分均与抑郁发作次数存在负相关关系（P＜0.05）；年龄、受教育年限、发作次数、总病程及HAMD24总分与MCCB量表评分间无相关性（P＞0.05）。结论 初诊双相障碍Ⅱ型抑郁发作患者认知功能改变与抑郁发作次数密切相关。
Abstract:
Objective To investigate the changes of cognitive function in patients with newly diagnosed bipolar disorder type Ⅱ depressive episode and its relationship with clinical characteristics.Methods From January 2018 to January 2021, 172 patients with newly diagnosed bipolar disorder type Ⅱ depressive episode and 172 healthy people who were recruited in the physical examination center of our hospital during the same period were included. The general data, clinical characteristics, MATRICS Consensus Cognitive Battery(MCCB) and the incidence of cognitive impairment were compared between the two groups, and the correlation between clinical symptoms and cognitive function was further evaluated.Results There was no significant difference in gender, age and years of education between the two groups (P>0.05). The total score of HAMD24 scale in the observation group was higher than that in the control group (P<0.05). The information processing score, attention alertness score, working memory score, word learning score, visual learning score, reasoning and problem solving score, social cognitive score and MCCB total score of the observation group were lower than those of the control group (P<0.05). The proportion of MCCB scale scores lower than 1, 1.5 and 2 standard deviations in the observation group was higher than that in the control group (P<0.05). The results of correlation analysis showed that the scores of patients’ word learning ability, reasoning and problem solving ability were negatively correlated with the number of depressive episodes (P<0.05). There was no correlation between age, years of education, number of episodes, total course of disease and HAMD24 total score and MCCB scale score (P>0.05).Conclusion The changes of cognitive function in patients with newly diagnosed bipolar disorder type Ⅱ depressive episode are closely related to the number of depressive episodes.

参考文献/References:

[1]El Nagar Z,El Shahawi HH,Effat SM,et al.Single episode brief psychotic disorder versus bipolar disorder: A diffusion tensor imaging and executive functions study[J].Schizophr Res Cogn,2021,27(9):100214.[2]Xu X,Xiang H,Qiu Y,et al.Sex differences in cognitive function of first-diagnosed and drug-naive patients with bipolar disorder[J].J Affect Disord,2021,295(9):431-437.[3]Huang Y,Wang Y,Wang H,et al.Prevalence of mental disorders in China: a cross-sectional epidemiological study[J].Lancet Psychiatry,2019,6(3):211-224.[4]Bomyea JA,Parrish EM,Paolillo EW,et al.Relationships between daily mood states and real-time cognitive performance in individuals with bipolar disorder and healthy comparators: A remote ambulatory assessment study[J].J Clin Exp Neuropsychol,2021,8(9):1-12.[5]汪作为,马燕桃,陈俊,等.中国双相障碍防治指南:基于循证的选择[J].中华精神科杂志,2017,50(2):96-100.[6]Simjanoski M,McIntyre A,Kapczinski F,et al.Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review[J].Trends Psychiatry Psychother,2021,9(8):1152-1159.[7]Simjanoski M,Jansen K,Mondin TC,et al.Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study[J].Psychiatry Res,2021,300(6):113894.[8]Simonetti A,Kurian S,Saxena J,et al.Cognitive correlates of impulsive aggression in youth with pediatric bipolar disorder and bipolar offspring[J].J Affect Disord,2021,287(5):387-396.[9]Douglas KM,Gallagher P,Robinson LJ,et al.Prevalence of cognitive impairment in major depression and bipolar disorder[J].Bipolar Disord,2018,20(3):260-274.[10]Petersen JZ,Macoveanu J,Kj?覸rstad HL,et al.Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt[J].J Psychopharmacol,2021,35(8):983-991.[11]Miskowiak KW,Jespersen AE,Obenhausen K,et al.Internet-based cognitive assessment tool: Sensitivity and validity of a new online cognition screening tool for patients with bipolar disorder[J].J Affect Disord,2021,289(6):125-134.[12]Liu T,Zhong S,Wang B,et al.Similar profiles of cognitive domain deficits between medication-na?觙ve patients with bipolar Ⅱ depression and those with major depressive disorder[J].J Affect Disord,2019,243(10):55-61.[13]Ribera C,Vidal-Rubio SL,Romeu-Climent JE,et al.Cognitive impairment and consumption of mental healthcare resources in outpatients with bipolar disorder[J].J Psychiatr Res,2021,138(6):535-540.[14]Callahan BL,McLaren-Gradinaru M,Burles F,et al.How Does Dementia Begin to Manifest in Bipolar Disorder? A Description of Prodromal Clinical and Cognitive Changes[J].J Alzheimers Dis,2021,82(2):737-748.[15]Beunders AJM,Kemp T,Korten NCM,et al.Cognitive performance in older-age bipolar disorder: Investigating psychiatric characteristics, cardiovascular burden and psychotropic medication[J].Acta Psychiatr Scand,2021,144(4):392-406.[16]Macoveanu J,Freeman KO,Kjaerstad HL,et al.Structural brain abnormalities associated with cognitive impairments in bipolar disorder[J].Acta Psychiatr Scand,2021,144(4):379-391.[17]Burdick KE,Millett CE.Cognitive heterogeneity is a key predictor of differential functional outcome in patients with bipolar disorder[J].Eur Neuropsychopharmacol,2021,53(7):4-6.[18]Millett CE,Harder J,Locascio JJ,et al.TNF-α and its soluble receptors mediate the relationship between prior severe mood episodes and cognitive dysfunction in euthymic bipolar disorder[J].Brain Behav Immun,2020,88(7):403-410.[19]Tsapekos D,Strawbridge R,Cella M,et al.Cognitive impairment in euthymic patients with bipolar disorder: Prevalence estimation and model selection for predictors of cognitive performance[J].J Affect Disord,2021,294(11):497-504.

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更新日期/Last Update: 1900-01-01