[1]胡雪涛,杨小亚,安黎明.宫颈癌活检病理与术后石蜡病理两种诊断方法的价值[J].医学信息,2024,37(12):130-132140.[doi:10.3969/j.issn.1006-1959.2024.12.029]
　HU Xue-tao,YANG Xiao-ya,AN Li-ming.Value of Two Diagnostic Methods of Cervical Cancer Biopsy Pathology and Postoperative Paraffin Pathology[J].Journal of Medical Information,2024,37(12):130-132140.[doi:10.3969/j.issn.1006-1959.2024.12.029]
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宫颈癌活检病理与术后石蜡病理两种诊断方法的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年12期
页码:
130-132140
栏目:
论著
出版日期:
2024-06-15

文章信息/Info

Title:
Value of Two Diagnostic Methods of Cervical Cancer Biopsy Pathology and Postoperative Paraffin Pathology
文章编号:
1006-1959（2024）11-0130-04
作者:
胡雪涛; 杨小亚; 安黎明
（北京市房山区中医医院病理科，北京 102400）
Author(s):
HU Xue-tao; YANG Xiao-ya; AN Li-ming
(Department of Pathology,Fangshan District Hospital of Traditional Chinese Medicine,Beijing 102400,China)
关键词:
宫颈癌; 活检病理; 石蜡病理
Keywords:
Cervical cancer; Biopsy pathology; Paraffin pathology
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2024.12.029
文献标志码:
A
摘要:
目的 研究宫颈癌活检病理与术后石蜡病理两种诊断方法的价值。方法 选取2020年12月-2023年6月我院诊治的269例疑似宫颈癌患者为研究对象，术前均进行宫颈病理活检诊断，术后进行病理石蜡切片诊断，观察两种诊断方法检测结果、不同病理类型诊断符合率、不同病理分期诊断符合率以及诊断效能（灵敏度、特异度、准确率）。结果 术后石蜡病理诊断不同病理类型宫颈疾病例数与阴道镜下宫颈活检病理检查比较，差异有统计学意义（P＜0.05）；不同病理类型阴道镜下宫颈活检病理检查诊断符合率比较，差异有统计学意义（P＜0.05）；Ⅰa2期~Ⅱb期阴道镜下宫颈活检病理诊断符合率为66.67%，高于原位癌~Ⅰa1期的60.00%（P＜0.05）；与术后石蜡病理诊断结果比较，宫颈癌活检病理灵敏度、特异度、准确率均较低。结论 宫颈癌术后石蜡病理诊断价值更高，术前阴道镜下宫颈病理活检虽然利于高级别鳞状上皮内病变、原位癌~Ⅰa1期宫颈癌的检出，但是诊断存在漏检可能性，临床应尽量开展有效的病理会诊，为后续治疗提供合理依据。
Abstract:
bjective To study the value of two diagnostic methods of cervical cancer biopsy and postoperative paraffin pathology.Methods A total of 269 patients with suspected cervical cancer diagnosed and treated in our hospital from December 2020 to June 2023 were selected as the research objects. Cervical pathological biopsy was performed before operation, and pathological paraffin section diagnosis was performed after operation. The detection results of the two diagnostic methods, the diagnostic coincidence rate of different pathological types, the diagnostic coincidence rate of different pathological stages and the diagnostic efficiency (sensitivity, specificity and accuracy) were observed.Results The number of cases of different pathological types of cervical diseases diagnosed by postoperative paraffin pathology was significantly different from that of cervical biopsy under colposcopy (P<0.05). There were significant differences in the coincidence rate of pathological examination of cervical biopsy among different pathological types (P<0.05). The coincidence rate of pathological diagnosis of cervical biopsy under colposcopy in stage Ⅰa2-Ⅱb was 66.67%, which was higher than 60.00% in carcinoma in situ-stage Ⅰa1 (P<0.05). Compared with the results of postoperative paraffin pathological diagnosis, the sensitivity, specificity and accuracy of cervical cancer biopsy were lower.Conclusion The value of paraffin pathological diagnosis after cervical cancer surgery is higher. Although preoperative cervical pathological biopsy under colposcopy is conducive to the detection of high-grade intraepithelial neoplasia and carcinoma in carcinoma in situ-stage Ⅰa1 cervical cancer, there is a possibility of missed diagnosis. Effective pathological consultation should be carried out as far as possible to provide a reasonable basis for subsequent treatment.

参考文献/References:

[1]黄颖.LEEP术后病理检查与阴道镜宫颈活检对宫颈癌前病变诊断的准确性研究[J].吉林医学,2020,12(3):114-116.[2]方明辉.宫颈活检为CIN3级锥切术后病理升级为宫颈癌的相关因素分析[J].桂林医学院,2021,6(1):106-108.[3]徐水芳,徐凤英,王桂芳,等.LEEP术后病理检查与阴道镜宫颈活检对宫颈癌前病变的诊断准确性[J].实用癌症杂志,2019,25(3):231-235.[4]丁亚芳,方萍,李洪梅.探讨阴道镜下四象限活检在宫颈癌筛查中的临床应用价值[J].现代诊断与治疗,2022,8(4):124-126.[5]刘钰,王君梅.阴道镜下宫颈活检诊断宫颈上皮内瘤变的准确性及其漏诊宫颈癌的影响因素[J].贵州医药,2022,28(1):182-185.[6]曲首辉,鲍志敏,刘荣欣,等.TCT、活检病理在宫颈上皮瘤变及早期宫颈癌诊断中的价值分析[J].天津医科大学学报,2018,24(4):360-362.[7]龙玉惠,杨娇娥.人乳头瘤病毒DNA分型检测宫颈液基薄层细胞学检查及阴道镜活检组织病理学检查在宫颈癌筛查中的应用价值[J].中国妇幼保健,2021,36(10):2419-2421.[8]王梅霞.宫颈锥切术联合术中冰冻病理检查在高级别宫颈上皮内瘤变诊断与治疗中的价值[J].河北医科大学,2018,3(1):185-187.[9]于康军,牛三强,胡猛,等.micro RNA-211 在宫颈癌外周血清中的表达及其与临床病理特征的关系[J].现代肿瘤医学,2020,28(10):1750-1753.[10]徐晓锋,王纯,卢国丰,等.宫颈癌患者 Kruppel 样因子6,p21蛋白表达水平与病理特征及化疗敏感性的相关性分析[J].现代检验医学杂志,2020,35(6):12-15.[11]黄琼.LEEP术后病理检查与阴道镜宫颈活检对宫颈癌前病变的诊断准确性及宫颈癌漏诊相关因素分析[J].中国妇幼保健,2020,35(5):960-963.[12]薛小芳,岳会珠,何涯丽.自噬相关蛋白Atg5和Beclin-1 在宫颈癌组织中的表达及与临床病理的相关性[J].实用癌症杂志,2021,36(10):1601-1604,1613.[13]曹倩文,尤志学,钱晓月,等.绝经后子宫颈高级别鳞状上皮内病变诊治方式的探讨[J].中华妇产科杂志,2019,54(6):393-398.[14]李侠,金艳,袁幼红.宫颈环形电切术及冷刀锥切术治疗宫颈上皮内瘤变患者疗效分析[J]临床军医杂志,2018,46(7):827－828.[15]沈成万.宫颈癌病理活检与术后病理石蜡切片的符合率分析[J].宁德师范学院学报,2020,28(9):73－75.[16]陈志强,米贤军,陈昂,等.免疫组织化学法检测子宫颈组织p16蛋白表达的石蜡切片厚度探讨[J].浙江大学学报(医学版),2018,47(4):362-366.[17]彭梅,索玉平,屈重霄,等.HPVE6/E7m RNA基因在HPV52、58型阳性患者宫颈病变组织中的表达[J].山西医科大学学报,2018,49(8):968-970.[18]于文力.LEEP术后病理检查与阴道镜宫颈活检对宫颈癌前病变诊断的准确性[J].中国药物经济学,2017,12(4):135-137.[19]刘英霞,黄卓雅,钟鸣,等.宫颈癌病理分期与临床分期差异性及影响淋巴结转移的危险因素分析[J].哈尔滨医药,2021,41(3):29-31.

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更新日期/Last Update: 1900-01-01