[1]黄少敏,祝建玲,赖旭佳,等.TRPC1在食管胃结合部腺癌中的表达及临床病理意义[J].医学信息,2024,37(18):65-69.[doi:10.3969/j.issn.1006-1959.2024.18.011]
 HUANG Shao-min,ZHU Jian-ling,LAI Xu-jia,et al.Expression and Clinicopathological Significance of TRPC1 in Adenocarcinomaof Esophagogastric Junction[J].Journal of Medical Information,2024,37(18):65-69.[doi:10.3969/j.issn.1006-1959.2024.18.011]
点击复制

TRPC1在食管胃结合部腺癌中的表达及临床病理意义()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年18期
页码:
65-69
栏目:
论著
出版日期:
2024-09-15

文章信息/Info

Title:
Expression and Clinicopathological Significance of TRPC1 in Adenocarcinomaof Esophagogastric Junction
文章编号:
1006-1959(2024)18-0065-05
作者:
黄少敏1祝建玲1赖旭佳2陈树钦1曾芸珠1
1.汕头大学医学院附属肿瘤医院病理科,广东 汕头 515031;2.普宁华侨医院病理科,广东 普宁 515300
Author(s):
HUANG Shao-min1ZHU Jian-ling1LAI Xu-jia2CHEN Shu-qin1ZENG Yun-zhu1
1.Department of Pathology,Cancer Hospital of Shantou University Medical College,Shantou 515031,Guangdong,China;2.Department of Pathology,Puning Overseas Chinese Hospital,Puning 515300,Guangdong,China
关键词:
食管胃结合部腺癌TRPC1肿瘤免疫微环境
Keywords:
Adenocarcinoma of esophagogastric junctionTRPC1Tumor immune microenvironment
分类号:
R735.1
DOI:
10.3969/j.issn.1006-1959.2024.18.011
摘要:
目的 探讨TRPC1在食管胃结合部腺癌(AEG)中的表达情况及其与患者临床病理特征、肿瘤免疫微环境的关系。方法选取2017年8月-2022年7月汕头大学医学院附属肿瘤医院病理科接收的AEG标本83例,以及27例正常胃黏膜组织。采用免疫组化检测AEG患者肿瘤组织和正常胃黏膜组织TRPC1的表达;分析TRPC1在肿瘤组织和正常胃黏膜组织表达的差异及其与临床病理特征及肿瘤免疫微环境的关系。结果 AEG患者正常胃黏膜组织有不同程度TRPC1表达,肿瘤组织TRPC1存在异常表达;83例患者TRPC1表达的H评分均值为84,其中低表达TRPC1有50例(60.24%),高表达TRPC1有33例(39.76%)。TRPC1表达与患者性别、年龄、病理T分期、淋巴结转移、神经侵犯、脉管侵犯、组织学分化程度、免疫指标均无相关性(P>0.05);Spearman等级相关检验分析显示,TRPC1表达与CD8、CD163、LAG-3均无相关性(P>0.05),但CD8与LAG-3呈负相关(r=-0.226,P=0.040)。结论 AEG中TRPC1的异常表达与患者临床病理特征、肿瘤浸润淋巴细胞均无相关性。
Abstract:
Objective To investigate the expression of TRPC1 in adenocarcinoma of esophagogastric junction (AEG) and its relationship with clinicopathological features and tumor immune microenvironment.Methods A total of 83 AEG specimens and 27 normal gastric mucosa tissues were selected from the Department of Pathology, Cancer Hospital of Shantou University Medical College from August 2017 to July 2022. The expression of TRPC1 in tumor tissues and normal gastric mucosa tissues of AEG patients was detected by immunohistochemistry. The difference of TRPC1 expression between tumor tissues and normal gastric mucosa tissues and its relationship with clinicopathological features and tumor immune microenvironment were analyzed.Results TRPC1 was expressed in different degrees in normal gastric mucosa tissues of AEG patients, and abnormal expression of TRPC1 was found in tumor tissues. The mean H score of TRPC1 expression in 83 patients was 84, including 50 cases (60.24%) with low expression of TRPC1 and 33 cases (39.76%) with high expression of TRPC1. The expression of TRPC1 was not correlated with gender, age, pathological T stage, lymph node metastasis, nerve invasion, vascular invasion, histological differentiation and immune index (P>0.05). Spearman rank correlation test showed that TRPC1 expression was not correlated with CD8, CD163 and LAG-3 (P>0.05), but CD8 was negatively correlated with LAG-3 (r=-0.226, P=0.040).Conclusion The abnormal expression of TRPC1 in adenocarcinoma of esophagogastric junction is not related to clinicopathological features and tumor infiltrating lymphocytes.

参考文献/References:

[1]Elzamzamy OM,Penner R,Hazlehurst LA.The Role of TRPC1 in Modulating Cancer Progression[J].Cells,2020,9(2):388.[2]Tai YK,Chan KKW,Fong CHH,et al.Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach[J].Front Oncol,2022,11:783803.[3]Azimi I,Milevskiy MJG,Kaemmerer E,et al.TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells[J].J Cell Sci,2017,130(14):2292-2305.[4]张荣,陈婧,黄江涛,等.TRPC3在胰腺癌细胞系中的表达及功能[J].现代肿瘤医学,2020,28(15):2560-2565.[5]Selli C,Pearce DA,Sims AH,et al.Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing[J].Mol Cell Biochem,2016,420(1-2):129-140.[6]Guéguinou M,Harnois T,Crottes D,et al.SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline[J].Oncotarget,2016,7(24):36168-36184.[7]Bomben VC,Sontheimer H.Disruption of transient receptor potential canonical channel 1 causes incomplete cytokinesis and slows the growth of human malignant gliomas[J].Glia,2010,58(10):1145-1156.[8]Jiang HN,Zeng B,Zhang Y,et al.Involvement of TRPC channels in lung cancer cell differentiation and the correlation analysis in human non-small cell lung cancer[J].PLoS One,2013,8(6):e67637.[9]Asghar MY,Magnusson M,Kemppainen K,et al.Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression: IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION[J].J Biol Chem,2015,290(26):16116-16131.[10]Zhang LY,Zhang YQ,Zeng YZ,et al.TRPC1 inhibits the proliferation and migration of estrogen receptor-positive Breast cancer and gives a better prognosis by inhibiting the PI3K/AKT pathway[J].Breast Cancer Res Treat,2020,182(1):21-33.[11]Zeng YZ,Zhang YQ,Chen JY,et al.TRPC1 Inhibits Cell Proliferation/Invasion and Is Predictive of a Better Prognosis of Esophageal Squamous Cell Carcinoma[J].Front Oncol,2021,11:627713.[12]Yang Z,Wang YG,Su K.VEGF-C and VEGF-D expression and its correlation with lymph node metastasis in esophageal squamous cell cancer tissue[J].Asian Pac J Cancer Prev,2015,16(1):271-274.[13]Detre S,Saclani Jotti G,Dowsett M.A "quickscore" method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas[J].J Clin Pathol,1995,48(9):876-878.[14]McClelland RA,Finlay P,Walker KJ,et al.Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer[J].Cancer Res,1990,50(12):3545-3550.[15]Treppiedi E,Giacopuzzi S,de Pascale S.Adenocarcinoma of the esophagogastric junction; going up or down?[J].Gastric Cancer,2020,23(5):948-949.[16]Pang T,Nie M,Yin K.The correlation between the margin of resection and prognosis in esophagogastric junction adenocarcinoma[J].World J Surg Oncol,2023,21(1):316.[17]Pottier C,Wheatherspoon A,Roncarati P,et al.The importance of the tumor microenvironment in the therapeutic management of cancer.Expert Rev Anticancer Ther.2015;15(8):943-954.[18]杨敏,蒋敬庭,卢斌峰.肿瘤浸润CD8+T淋巴细胞的功能缺失分子机制[J].临床检验杂志,2016,34(1):42-45.[19]Li SM,Gong YX,Zhang ZZ,et al.Effect of Radical Surgery for Advanced Adenocarcinoma of Esophagogastric Junction on Perioperative Cellular Cell Immunity[J].J Invest Surg,2021,34(2):134-141.[20]Wang J,Sanmamed MF,Datar I,et al.Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3[J].Cell,2019,176(1-2):334-347.e12.[21]Chen Z,Zhao M,Liang J,et al.Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma[J].E Bio Medicine,2021,69:103459.

相似文献/References:

[1]李 尤,王子卫.食管胃结合部腺癌的研究进展[J].医学信息,2019,32(13):39.[doi:10.3969/j.issn.1006-1959.2019.13.013]
 LI You,WANG Zi-wei.Advances in Research on Esophageal and Gastric Junction Adenocarcinoma[J].Journal of Medical Information,2019,32(18):39.[doi:10.3969/j.issn.1006-1959.2019.13.013]

更新日期/Last Update: 1900-01-01