[1]陈宝兰,缪建平,谌 帆,等.鼻负压置换联合机械辅助排痰氧气雾化治疗小儿肺炎的临床研究[J].医学信息,2024,37(22):38-41.[doi:10.3969/j.issn.1006-1959.2024.22.009]
　CHEN Baolan,MIAO Jianping,SHEN Fan,et al.Clinical Study of Nasal Negative Pressure Replacement Combined with Mechanical Assisted Expectoration Oxygen Atomization in the Treatment of Pneumonia in Children[J].Journal of Medical Information,2024,37(22):38-41.[doi:10.3969/j.issn.1006-1959.2024.22.009]
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鼻负压置换联合机械辅助排痰氧气雾化治疗小儿肺炎的临床研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年22期
页码:
38-41
栏目:
论著
出版日期:
2024-11-15

文章信息/Info

Title:
Clinical Study of Nasal Negative Pressure Replacement Combined with Mechanical Assisted Expectoration Oxygen Atomization in the Treatment of Pneumonia in Children
文章编号:
1006-1959（2024）22-0038-04
作者:
陈宝兰1; 缪建平1; 谌 帆1; 赖玉婷2
1.定南县第一人民医院儿科，江西 定南 341900；2.赣州市人民医院儿科，江西 赣州 341000
Author(s):
CHEN Baolan1; MIAO Jianping1; SHEN Fan1; LAI Yuting2
1.Department of Pediatrics,Dingnan County First People’s Hospital,Dingnan 341900,Jiangxi,China;2.Department of Pediatrics,Ganzhou People’s Hospital,Ganzhou 341000,Jiangxi,China
关键词:
鼻负压置换; 机械辅助排痰; 氧气雾化; 肺炎
Keywords:
Nasal negative pressure replacement; Mechanically assisted sputum elimination; Oxygen atomization; Pneumonia
分类号:
R563.1
DOI:
10.3969/j.issn.1006-1959.2024.22.009
摘要:
目的 研究鼻负压置换联合机械辅助排痰氧气雾化治疗小儿肺炎的临床疗效。方法 选取2022年3月-2023年9月在我院诊治的72例小儿肺炎患儿为研究对象，采用随机数字表法分为对照组和研究组，各组36例。对照组采用机械辅助排痰氧气雾化治疗，研究组在对照组基础上联合鼻负压置换治疗。比较两组治疗效果、临床症状（咳嗽、体温、肺部啰音）消失时间、血气指标[氧分压（PaO2）、二氧化碳分压（PaCO2）、pH]、炎性因子[C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）]水平。结果 研究组治疗总有效率（94.44%）高于对照组（83.33%）（P＜0.05）；研究组咳嗽消失、体温恢复正常、肺部啰音消失时间均短于对照组（P＜0.05）；两组治疗后PaO2、pH高于治疗前，PaCO2低于治疗前，且研究组PaO2、pH高于对照组，PaCO2低于对照组（P＜0.05）；两组治疗后CRP、PCT、IL-6水平均低于治疗前，且研究组低于对照组（P＜0.05）。结论 鼻负压置换联合机械辅助排痰氧气雾化治疗小儿肺炎临床效果理想，可提高总有效率，改善血气指标，减轻炎症反应，利于患儿临床症状的快速消失，值得临床加以应用。
Abstract:
Objective To study the clinical efficacy of nasal negative pressure replacement combined with mechanical assisted sputum oxygen atomization in the treatment of children with pneumonia.Methods A total of 72 children with pneumonia diagnosed and treated in our hospital from March 2022 to September 2023 were selected as the research objects. They were divided into control group and study group by random number table method, with 36 children in each group. The control group was treated with mechanical assisted expectoration oxygen atomization, and the study group was treated with nasal negative pressure replacement on the basis of the control group. The treatment effect, disappearance time of clinical symptoms (cough, body temperature, lung rale), blood gas indexes [oxygen partial pressure (PaO2), carbon dioxide partial pressure (PaCO2), pH], inflammatory factors [C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6)] were compared between the two groups.Results The total effective rate of treatment in the study group (94.44%) was higher than that in the control group (83.33%) (P<0.05). The time of cough disappearance, body temperature recovery and lung rale disappearance in the study group were shorter than those in the control group (P<0.05). After treatment, PaO2 and pH in the two groups were higher than those before treatment, PaCO2 was lower than that before treatment, and PaO2 and pH in the study group were higher than those in the control group, PaCO2 was lower than that in the control group (P<0.05). After treatment, the levels of CRP, PCT and IL-6 in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P<0.05).Conclusion The clinical effect of nasal negative pressure replacement combined with mechanical assisted expectoration and oxygen atomization in the treatment of pediatric pneumonia is ideal, which can improve the total effective rate, improve the blood gas index, reduce the inflammatory reaction, and is conducive to the rapid disappearance of clinical symptoms in children. It is worthy of clinical application.

参考文献/References:

[1]张建丽.静脉滴注联合雾化吸入沐舒坦治疗新生儿肺炎临床疗效[J].包头医学院学报,2016,32(5):97-98.[2]卢金英,郝明明,常涛涛.布地奈德联合盐酸氨溴索雾化吸入治疗小儿支气管肺炎的疗效研究[J].山西医药杂志,2017,46(23):2906-2907.[3]徐艳丽.儿童肺炎支原体感染应用阿奇霉素联合头孢类抗生素及布地奈德雾化吸入治疗的效果研究[J].国际儿科学杂志,2016,43(5):417-419.[4]蔡惠东,潘剑蓉.沙丁胺醇联合布地奈德氧气雾化吸入与超声雾化吸入对小儿肺炎疗效及炎症因子的改善对比探析[J].检验医学与临床,2017,14(18):2745-2747.[5]王丹,黄辉,魏广友,等.机械辅助排痰治疗小儿大叶性肺炎的疗效评价[J].现代科学仪器,2021,38(3):191-195.[6]诸小飞,凌莉,曹婷婷.无创机械通气后经鼻低流量氧疗对AECOPD合并Ⅱ型呼吸衰竭的疗效分析[J].中国基层医药,2023,30(10):1529-1533.[7]尹丽娟,宝凌云,姚静.机械振动辅助排痰在新生儿感染性肺炎中的应用效果[J].昆明医科大学学报,2022,43(3):166-170.[8]张艳萍.小剂量多巴胺联合磷酸肌酸钠治疗小儿肺炎并心衰的临床疗效及对血清 IGF-1、D-D水平的影响[J].中西医结合心血管病电子杂志,2021,9(5):26-28.[9]李各强.血浆纤维蛋白原与C-反应蛋白检验对小儿肺炎的临床应用及意义[J].中国医药科学,2021,11(13):134-136,157.[10]王玥梅,李军文,侯冬,等.鼻导管吸氧治疗重症肺炎伴呼吸衰竭新生儿的效果[J].吉林医学,2023,15(7):38-40.[11]兰婷婷,詹璐,邓全敏,等.纤维支气管镜肺泡灌洗术联合振动排痰法在重症肺炎机械通气患儿的临床应用[J].临床与病理杂志,2021,41(3):582-589.[12]巩娟,张栋,段兴隆.振动排痰+纤支镜对重症肺炎患者肺泡氧合功能、呼吸功能的影响[J].贵州医药,2021,45(12):1919-1920.[13]刘倩,闫俊梅.人免疫球蛋白联合经鼻高流量湿化氧疗辅助治疗重症新生儿肺炎的临床效果[J].国际免疫学杂志,2021,44(3):274-279.[14]黄丽华,孙贻霞,年福慧,等.机械辅助排痰与人工叩背排痰对儿童支原体肺炎治疗效果的比较[J].安徽医学,2020,41(11):1356-1358.[15]禤瑞华,张明真.经鼻持续气道正压通气在46例小儿重症肺炎治疗中的应用效果[J].上海医药,2017,12(10):23-26.[16]魏威,苏凯,高学,等.对比观察鼻罩导气管在胃镜检查麻醉期间预防低氧血症的作用[J].国际麻醉学与复苏杂志,2022,43(12):1277-1281.[17]石丹英,张红英.加温湿化高流量鼻导管氧疗与nCPAP在小儿重症肺炎呼吸衰竭辅助治疗中的应用对比观察[J].山东医药,2021,25(6):104-106.[18]黎敏,吴赞,张玉明.鼻腔冲洗联合雾化吸入治疗婴幼儿肺炎的疗效观察[J].中国医药科学,2019,25(3):102-105.[19]杜海燕,孙亚凯,刘波,等.经鼻持续气道正压通气与头罩/鼻导管吸氧治疗重症新生儿肺炎的临床疗效[J].海南医学,2023,25(8):27-29.[20]李小娟.高流量鼻导管湿化氧疗治疗新生儿重症肺炎临床效果观察[J].现代诊断与治疗,2017,10(8):68-71.

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更新日期/Last Update: 1900-01-01