[1]阎 勤,苏 华,黄玉玲,等.响应曲面法研究百眼藤总蒽醌的提取工艺研究[J].医学信息,2025,38(02):76-81.[doi:10.3969/j.issn.1006-1959.2025.02.013]
　YAN Qin,SU Hua,HUANG Yulin,et al.Study on the Extraction Process of Total Anthraquinones from Caulis Marsdeniae by Response Surface Methodology[J].Journal of Medical Information,2025,38(02):76-81.[doi:10.3969/j.issn.1006-1959.2025.02.013]
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响应曲面法研究百眼藤总蒽醌的提取工艺研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年02期
页码:
76-81
栏目:
药学信息学
出版日期:
2025-01-15

文章信息/Info

Title:
Study on the Extraction Process of Total Anthraquinones from Caulis Marsdeniae by Response Surface Methodology
文章编号:
1006-1959（2025）02-0076-06
作者:
阎 勤1; 苏 华2; 黄玉玲1; 江 蓓1; 马雪莹3; 罗茜怡4
1.柳州市妇幼保健院药学部，广西 柳州 545001；2.广西中医药研究院中药药效与安全性评价中心，广西 南宁 530022；3.右江民族医学院药学院，广西 百色 533000；4.桂林医学院药学院，广西 桂林 541000
Author(s):
YAN Qin1;  SU Hua2;  HUANG Yulin1;  JIANG Bei1;  MA Xueying3;  LUO Xiyi4
1.Department of Pharmacy, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou 545001, Guangxi, China; 2.Department of Evaluation of the Efficacy and Safety of Traditional Chinese Medicine Center, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning 530022, Guangxi, China; 3.College of Pharmacy, Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China;4.College of Pharmacy Guilin Medical University, Guilin 541000, Guangxi, China
关键词:
百眼藤; 蒽醌; 响应曲面法
Keywords:
Morinda parvifolia;  Anthraquinone;  Response surface methodology
分类号:
R284.2
DOI:
10.3969/j.issn.1006-1959.2025.02.013
文献标志码:
A
摘要:
目的 对百眼藤总蒽醌的提取工艺进行研究，考察百眼藤总蒽醌小鼠单次给药毒性反应，为后续百眼藤总蒽醌的动物药效实验剂量设计提供理论依据。方法 利用分光光度法测定百眼藤提取物中总蒽醌的含量，采用响应曲面法对百眼藤提取工艺进行考察。结果 百眼藤总蒽醌的的最佳提取条件为提取溶剂66.26%乙醇，料液比1∶7.94，提取时间148.74 min。 结论 本研究为百眼藤药材中总蒽醌的最佳提取工艺提供了实验依据。
Abstract:
Objective To study the extraction process of total anthraquinone in Morinda parvifolia, and to investigate the single-dose toxicity of total anthraquinone in mice, so as to provide a theoretical basis for the dose design of animal efficacy experiment of total anthraquinone in Morinda parvifolia. Methods The content of total anthraquinones was determined by spectrophotometry, and the extraction process was investigated by response surface methodology. Results The optimum extraction conditions of total anthraquinones were as follows: extraction solvent 66.26% ethanol, solid-liquid ratio 1:7.94, extraction time 148.74 min. Conclusion This study provides an experimental basis for the optimal extraction process of total anthraquinones in Morinda parvifolia.

参考文献/References:

[1]国家中医药管理局.中华本草（第六卷）[M].上海:上海科学技术出版社,1999:5805-5806.[2]谢宗万.全国中草药汇编（上册）[M].北京:人民卫生出版社,1975:335.[3]Chang P,Lee KH,Shingu T,et al.Antitumor Agents 50.1 Morindaparvin-A, a new antileukemic anthraquinone, and alizarin-1-methyl ether from Morinda parvifolia, and the antileukemic activity of the related derivatives[J].J Nat Prod,1982,45(2):206-210.[4]Chang P,Lee KH.Cytotoxic antileukemic anthraquinones from Morinda parvifolia[J].Phytochemistry,1984,23(8):1733-1736.[5]蔡铱妮,孙红梅,陈亚贤,等.响应面法优化双水相提取巴戟天游离蒽醌[J].中药材,2022,45(5):1197-1201．[6]史友航,吕青遥,焦士蓉.响应面法优化微波辅助提取芦荟蒽醌类物质工艺及其抗氧化活性分析[J].食品工业科技,2023,44(19):174-181．[7]侯敏娜,侯少平,刘艳红,等.响应面法优化超声辅助提取浙贝母蒽醌工艺及其抑菌活性研究[J].江西农业学报,2020,32(10):81-86.[8]李钦青,董虹玲,张海,等.桑杞胶囊中总蒽醌含量测定的研究[J].中国中医药现代远程教育,2019,17(24):99-102.[9]韦汉燕,谢恒,廖迎,等.大血藤总蒽醌的含量测定及体外抗氧化活性的研究[J].华夏医学,2019,32(4):27-31.[10]胡筱希,朱荣,唐新,等.响应曲面法优化防己中汉防己甲素及汉防己乙素的提取工艺[J].中国民族民间医药,2020,29(1):25-30.[11]胡筱希,黄周锋,陆国寿,等.响应曲面法优化翼核果中翼核果素及翼核果醌-I的提取工艺[J].现代中药研究与实践,2019,33(1):58-62.[12]韩扬,何聪芬,董银卯,等.响应面法优化超声波辅助酶法制备燕麦ACE抑制肽的工艺研究[J].食品科学,2009,30(22):44-49.[13]温元凯,孙福革,林际兵,等.关于蒽醌类抗肿瘤新药的设计[J].自然杂志,1988(9):709.[14]丁平平,易斌,陈华师,等.炆何首乌饮片中蒽醌糖苷类成分变化与减毒效应[J].中国现代应用药学,2023,40(9):1180-1186.[15]张涛.炆何首乌物质基础、工艺及降低肝毒作用研究[D].南昌:江西中医药大学,2023.[16]陈学艳,魏文芝,张敏娟,等. UPLC法同时测定复方龙胆碳酸氢钠片中10种大黄蒽醌类成分及土大黄苷的含量[J].中国药房,2023,34(21):2595-2600.[17]陈宗燕,梁霜.HPLC法同时测定野菠菜中4种蒽醌类成分的含量[J].中国药师,2022,25(8):1452-1455.[18]王丽丽,徐东亮,王诗涵.一测多评法测定不同产地巴戟天中5种蒽醌类成分的含量[J].信阳师范学院学报(自然科学版),2022,35(2):290-294.[19]赵金秀,贾勇,安志英,等.超高效液相色谱(UHPLC)对大黄饮片炮制前后化学成分定性定量分析[J].化学工程师,2021,35(10):30-33.[20]陈秋铃.中药巴戟天的化学成分研究[D].广州:暨南大学,2022.

更新日期/Last Update: 1900-01-01