[1]罗健彰,易晓圆,石武祥,等.铁死亡的机制及在肝细胞癌中的应用现状[J].医学信息,2025,38(02):169-173178.[doi:10.3969/j.issn.1006-1959.2025.02.034]
 LUO Jianzhang,YI Xiaoyuan,SHI Wuxiang,et al.Mechanisms of Ferroptosis and its Current Applications in Hepatocellular Carcinoma[J].Journal of Medical Information,2025,38(02):169-173178.[doi:10.3969/j.issn.1006-1959.2025.02.034]
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铁死亡的机制及在肝细胞癌中的应用现状()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年02期
页码:
169-173178
栏目:
综述
出版日期:
2025-01-15

文章信息/Info

Title:
Mechanisms of Ferroptosis and its Current Applications in Hepatocellular Carcinoma
文章编号:
1006-1959(2025)02-0169-06
作者:
罗健彰1易晓圆1石武祥2汪丽燕3
1.桂林医学院研究生学院,广西 桂林 541000;2.桂林医学院人文与管理学院,广西 桂林 541000;3.桂林医学院附属医院消化内科,广西 桂林 541000
Author(s):
LUO Jianzhang1 YI Xiaoyuan1 SHI Wuxiang2 WANG Liyan3
1.Graduate School of Guilin Medical University, Guilin 541000, Guangxi, China;2.School of Humanities and Management, Guilin Medical University, Guilin 541000, Guangxi, China;3.Department of Digestive Medicine, Affiliated Hospital of Guilin Medical University, Guilin 541000, Guangxi, China
关键词:
铁死亡肝细胞癌肝脏恶性肿瘤索拉非尼
Keywords:
Ferroptosis Hepatocellular carcinoma Malignant tumors of the liver Sorafenib
分类号:
R735.7
DOI:
10.3969/j.issn.1006-1959.2025.02.034
文献标志码:
A
摘要:
肝细胞癌(HCC)是原发性肝癌中最常见的类型,通过逃避传统的细胞程序性死亡而不断生长、转移和耐药。铁死亡作为近十年来研究的热点之一,其特点是铁蓄积、脂质过氧化,以及抗氧化体系的失衡。目前在科研及临床上,通过诱导铁死亡来遏制HCC是一种新兴策略。本文概述了铁死亡的细胞形态、发生机制,并梳理了铁死亡在HCC中的分子靶点和最新应用,旨在为未来进一步的研究提供思路。
Abstract:
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which grows, metastasises, and becomes drug-resistant by evading conventional programmed cell death. Ferroptosis, one of the hotspots of research in the last decade, is characterized by iron accumulation, lipid peroxidation, and an imbalance in the antioxidant system. Containment of HCC by inducing ferroptosis is currently an emerging strategy in research and clinical practice. This article summarizes the cell morphology and mechanism of ferroptosis, and sorts out the molecular targets and latest applications of ferroptosis in HCC, aiming to provide ideas for further research in the future.

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