[1]欧阳婷.那屈肝素钙注射液在急性下肢深静脉血栓治疗中的有效性及安全性[J].医学信息,2025,38(04):120-123.[doi:10.3969/j.issn.1006-1959.2025.04.021]
　OUYANG Ting.Efficacy and Safety of Nadroparin Calcium Injection in the Treatment of Acute Lower Extremity Deep Venous Thrombosis[J].Journal of Medical Information,2025,38(04):120-123.[doi:10.3969/j.issn.1006-1959.2025.04.021]
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那屈肝素钙注射液在急性下肢深静脉血栓治疗中的有效性及安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年04期
页码:
120-123
栏目:
论著
出版日期:
2025-02-15

文章信息/Info

Title:
Efficacy and Safety of Nadroparin Calcium Injection in the Treatment of Acute Lower Extremity Deep Venous Thrombosis
文章编号:
1006-1959（2025）04-0120-04
作者:
欧阳婷
江西省人民医院进贤医院药剂科，江西 进贤 331700
Author(s):
OUYANG Ting
Pharmacy Department of Jiangxi Provincial People’s Hospital Jinxian Hospital, Jinxian 331700, Jiangxi, China
关键词:
急性下肢深静脉血栓; 那屈肝素钙注射液; 凝血功能; 下肢肿胀
Keywords:
Acute deep vein thrombosis of ower limbs;  Nadroparin calcium injection;  Coagulation function;  Lower limb swelling
分类号:
R543.6
DOI:
10.3969/j.issn.1006-1959.2025.04.021
文献标志码:
A
摘要:
目的 研究那屈肝素钙注射液在急性下肢深静脉血栓治疗中的应用疗效及安全性。方法 选取2020年1月-2023年12月江西省人民医院进贤医院收治的58例急性下肢深静脉血栓患者，经随机数字表法分为对照组（29例）和观察组（29例）。对照组行常规溶栓治疗，观察组在其基础上联合那屈肝素钙注射液治疗，比较两组临床疗效、凝血功能[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）]、患肢肿胀程度（大腿周径差、小腿周径差）、并发症发生情况。结果 观察组血管再通率高于对照组（P＜0.05）；两组治疗后PT、APTT指标大于治疗前，且观察组PT、APTT指标大于对照组（P＜0.05）；两组治疗后大腿周径差、小腿周径差均小于治疗前，且观察组大腿周径差、小腿周径差小于对照组（P＜0.05）；两组并发症发生率比较，差异无统计学意义（P＞0.05）。结论 那屈肝素钙注射液在急性下肢深静脉血栓治疗中具有确切疗效，可改善患者凝血功能，缓解其患肢肿胀，且具有良好安全性。
Abstract:
Objective To study the efficacy and safety of nadroparin calcium injection in the treatment of acute deep venous thrombosis of lower limbs. Methods A total of 58 patients with acute deep venous thrombosis of lower limbs admitted to the Jiangxi Provincial People’s Hospital Jinxian Hospital from January 2020 to December 2023 were selected and divided into control group (29 patients) and observation group (29 patients) by random number table method. The control group was treated with routine thrombolysis, and the observation group was treated with nadroparin calcium injection on the basis of the control group. The clinical efficacy, coagulation function [ prothrombin time (PT), activated partial thromboplastin time (APTT)], swelling degree of affected limb (thigh circumference difference, calf circumference difference) and complications were compared between the two groups. Results The vascular recanalization rate of the observation group was higher than that of the control group (P<0.05). The PT and APTT indexes of the two groups after treatment were higher than those before treatment, and the PT and APTT indexes of the observation group were higher than those of the control group (P<0.05). After treatment, the thigh circumference difference and calf circumference difference of the two groups were smaller than those before treatment, and the thigh circumference difference and calf circumference difference of the observation group were smaller than those of the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusion Nadroparin calcium injection has definite curative effect in the treatment of acute deep venous thrombosis of lower limbs, which can improve the coagulation function of patients, relieve the swelling of affected limbs, and has good safety.

参考文献/References:

[1]李倩,程浩,镇万源,等.加减桃红四物汤联合低分子肝素钙对下肢骨折术后深静脉血栓发生率、血流变及凝血功能的影响[J].湖北中医药大学学报,2023,25(6):92-94.[2]王金磊,杨晓龙,康春博.低分子肝素钙结合物理疗法预防长期卧床老年患者下肢深静脉血栓的效果[J].中华老年多器官疾病杂志,2023,22(7):512-515.[3]向忠,陈志武,胡国潢.腰椎术后那曲肝素钙预防下肢深静脉血栓的临床研究[J].湖南师范大学学报(医学版),2023,20(3):80-83,87.[4]王颖,王孝高,官泽宇,等.低分子肝素联合普通肝素在下肢深静脉血栓形成导管直接溶栓中的应用[J].中华全科医学,2023,21(4):568-571.[5]张永辉,李云霞,郑晓拓.低分子肝素钙辅以大腔导管血栓抽吸术对深静脉血栓患者血液流变学、凝血功能、炎症因子及治疗安全性的影响[J].岭南心血管病杂志,2023,29(1):55-59,105.[6]谷艳超,谢维,李莹,等.不同剂量低分子肝素预防腰椎内固定术后静脉血栓栓塞症的安全性分析[J].骨科,2021,12(5):421-425.[7]Hou J,Wang W,Cai H,et al.Patients With Right Lower Extremity Deep Vein Thrombosis Have a Higher Risk of Symptomatic Pulmonary Embolism: A Retrospective Study of 1585 Patients[J].Annals of Vascular Surgery,2022,81(1):240-248.[8]Qu SW,Cong YX,Wang PF,et al.Features for deep vein thrombosis in the uninjured limbs of lower extremity fractures: a retrospective study 1454 patients[J].Clin Appl Thromb Hemost,2021,27:1076029620986862.[9]游丰源,陈国仙,林宗锦,等.阿哌沙班与低分子肝素预防老年髋关节置换术后下肢深静脉血栓形成的有效性及安全性比较[J].中国骨与关节损伤杂志,2022,37(2):176-178.[10]张乐乐,刘怡,王梦妮,等.低分子肝素钙联合利伐沙班对腹腔镜下全子宫切除术后下肢深静脉血栓形成的预防效果[J].解放军医药杂志,2021,33(12):92-95.[11]何昕昕,丰艳,郭剑颖.低分子肝素对下肢骨折高龄患者凝血功能的影响及Sonoclot凝血及血小板功能分析仪监测效果评估[J].临床与病理杂志,2021,41(12):2894-2899.[12]孙伟文,杜新辉,邱忠鹏,等.利伐沙班和低分子肝素在下肢骨折中预防下肢深静脉血栓形成的安全性及疗效[J].临床骨科杂志,2021,24(6):818-821.[13]郑紫磊,张玉平,李海英.低分子量肝素与口服抗凝剂预防脊柱创伤后下肢深静脉血栓形成和肺栓塞研究[J].河北医学,2021,27(10):1661-1665.[14]刘琳,朱红江,刘明阳,等.低分子肝素联合尿激酶治疗下肢深静脉血栓的有效性及对生活质量的影响[J].中国临床保健杂志,2022,25(1):82-85.[15]刘志伟,孟凡星,叶欣,等.低分子肝素对老年股骨颈骨折患者围术期下肢静脉血栓的预防作用及风险评估[J].中国医刊,2021,56(6):624-626.[16]张嵘,何地芹,刘红娟,等.低分子肝素钠治疗高血压脑出血合并下肢深静脉血栓形成的疗效观察[J].颈腰痛杂志,2021,42(3):407-409.[17]王龙刚.低分子肝素钙对股骨粗隆间骨折患者术后下肢深静脉血栓风险的影响[J].中国药物与临床,2020,20(24):4119-4121.[18]宋江涛,陈嘉联.低分子肝素与利伐沙班预防脊柱外科术后下肢深静脉血栓比较[J].安徽医药,2020,24(12):2519-2522.[19]郭亚,李刚,葛玉堂.低分子肝素钙与阿哌沙班片预防老年髋部骨折患者下肢深静脉血栓形成的效果及安全性比较[J].上海医学,2022,45(11):763-768.[20]杨新华,刘鹏,朱军,等.低分子肝素钙预防腰椎退行性疾病术后深静脉血栓形成的有效性和安全性[J].局解手术学杂志,2020,29(2):134-137.[21]张晨,宋国瑞,刘子歌,等.低分子肝素与利伐沙班预防全膝关节置换术后静脉血栓成形的疗效及安全性对比分析[J].陕西医学杂志,2020,49(9):1153-1156.[22]莫智媛.低分子肝素钠联合气压治疗在预防妇科肿瘤术后下肢深静脉血栓(DVT)的临床效果和应用价值[J].现代预防医学,2020,47(14):2681-2684.[23]李洁,宋恒文,杨能,等.国产那屈肝素钙注射液在中国健康受试者中的生物等效性及安全性研究[J].中国药房,2022,33(16):2017-2021.

更新日期/Last Update: 1900-01-01