[1]刘琼兴,陈荣琳,路亚丽,等.SII、NLR、PLR水平与老年脓毒症预后的相关性[J].医学信息,2025,38(06):123-126.[doi:10.3969/j.issn.1006-1959.2025.06.021]
　LIU Qiongxing,CHEN Ronglin,LU Yali,et al.Correlation Between the Levels of SII, NLR, PLR and the Prognosis of Sepsis in the Elderly[J].Journal of Medical Information,2025,38(06):123-126.[doi:10.3969/j.issn.1006-1959.2025.06.021]
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SII、NLR、PLR水平与老年脓毒症预后的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年06期
页码:
123-126
栏目:
论著
出版日期:
2025-03-15

文章信息/Info

Title:
Correlation Between the Levels of SII, NLR, PLR and the Prognosis of Sepsis in the Elderly
文章编号:
1006-1959（2025）06-0123-04
作者:
刘琼兴1; 陈荣琳2; 路亚丽2; 黄 冠3
1.汕头大学医学院，广东 汕头 515041；2.深圳市龙岗中心医院重症医学科，广东 深圳 518116；3.深圳市龙岗中心医院病理科，广东 深圳 518116
Author(s):
LIU Qiongxing1;  CHEN Ronglin2;  LU Yali2;  HUANG Guan3
1.School of Medicine, Shantou University, Shantou 515041, Guangdong, China;2.Intensive Care Unit, Shenzhen Longgang Central Hospital, Shenzhen 518116, Guangdong, China;3.Department Pathology, Shenzhen Longgang Central Hospital, Shenzhen 518116, Guangdong, China
关键词:
SII; NLR; PLR; 脓毒症
Keywords:
SII;  NLR;  PLR;  Sepsis
分类号:
R631+.2
DOI:
10.3969/j.issn.1006-1959.2025.06.021
文献标志码:
A
摘要:
目的 研究系统免疫炎症指数（SII）、中性粒细胞与淋巴细胞计数比值（NLR）、血小板与淋巴细胞计数比值（PLR）水平与老年脓毒症患者预后的相关性。方法 选取2022年1月-2023年12月深圳市龙岗中心医院重症医学科收治的96例老年脓毒症患者为研究对象，依据28 d内患者预后分为生存组（81例）、死亡组（15例），比较两组患者临床资料（年龄、性别、APACHEⅡ评分及SII、NLR、PLR水平，并分析SII 水平与老年脓毒症患者预后危险因素的独立相关性。结果 生存组血清SII、去甲肾上腺素使用时间、去甲肾上腺素使用总量、呼吸机使用时间、感染情况与死亡组比较，差异有统计学意义（P＜0.05）；两组性别、年龄、APACHEⅡ评分、SOFA评分、NLR、PLR等指标比较，差异无统计学意义（P＞0.05）；Spearman相关性分析显示，SII与去甲肾上腺素使用总量、呼吸机和去甲肾上腺素使用时间均无明显相关性（P＞0.05）。结论 SII水平对老年脓毒症病情程度和预后具有一定的预测价值，可作为临床评估其病情严重程度和预后的辅助指标，值得临床应用。
Abstract:
Objective To study the correlation between systemic immune inflammation index (SII), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and prognosis in elderly patients with sepsis. Methods A total of 96 elderly patients with sepsis admitted to the Intensive Care Unit, Shenzhen Longgang Central Hospital from January 2022 to December 2023 were selected as the research objects. According to the prognosis of patients within 28 days, they were divided into survival group (81 patients) and death group (15 patients). The clinical data (age, gender, APACHEⅡ score, SII, NLR and PLR levels) of the two groups were compared, and the independent correlation between SII level and prognostic risk factors of elderly patients with sepsis was analyzed. Results There were significant differences in serum SII, norepinephrine use time, total norepinephrine use, ventilator use time and infection between the survival group and the death group (P<0.05). There was no significant difference in gender, age, APACHEⅡ score, SOFA score, NLR and PLR between the two groups (P>0.05). Spearman correlation analysis showed that there was no significant correlation between SII and total norepinephrine use, ventilator and norepinephrine use time (P>0.05). Conclusion The level of SII has a certain predictive value for the severity and prognosis of sepsis in the elderly, which can be used as an auxiliary index to evaluate the severity and prognosis of sepsis in the elderly. It is worthy of clinical application.

参考文献/References:

[1]Chiu C,Legrand M.Epidemiology of sepsis and septic shock[J].Curr Opin Anaesthesiol,2021,34(2):71-76.[2]Weng L,Xu Y,Yin P,et al.National incidence and mortality of hospitalized sepsis in China[J].Crit Care,2023,27(1):84.[3]顾晓霞,高振军.溃疡性结肠炎患者肠道菌群失调与H.pylori感染和DAI评分及免疫球蛋白水平的相关性[J].中国微生态学杂志,2023,35(3):348-352.[4]杨银娟,尚亚楠,尚向涛.脓毒症患者肠道细菌紊乱与炎性细胞因子及T淋巴细胞亚群的相关性[J].中国急救复苏与灾害医学杂志,2020,15(9):1092-1095[5]Zhao DN,Li SL,Cui J,et al.Plasma miR-125a and miR-125b insepsis: correlation with disease risk, inflammation, severity,and prognosis[J].J Clin Lab Anal,2020,34(2):e23036.[6]中国医师协会急诊医师分会,中国研究型医院学会休克与脓毒症专业委员会.中国脓毒症/脓毒性休克急诊治疗指南(2018)[J].中国急救医学,2018,38(9):741-756.[7]李超,李妮妮,吕红霞,等.微小RNA-122a、微小RNA-133a-3P与脓毒症患者严重程度、预后的关系[J].中国临床医生杂志,2022,50(5):586-588.[8]赵娜,赵宁,申晓楠,等.脓毒症患者的凝血功能、炎症因子变化及其与病情严重程度和预后的相关性[J].海南医学,2024,35(6):844-848.[9]陈君,王妮,陈栩栩,等.ICU脓毒症患者血清Presepsin、内毒素、IL-6、PCT水平与预后的相关性[J].中华医院感染学杂志,2022,32(3):356-359.[10]张赟,陈娟,黄尧米.血浆Th1/Th2细胞、ET、PTA、PCT与脓毒症患儿病情严重程度及转归的关系分析[J].河北医科大学学报,2022,43(12):1449-1453.[11]余广炜,林增杰,涂福泉,等.中性粒细胞/淋巴细胞比值联合随机血糖对脓毒症预测价值[J].中华急诊医学杂志,2024,33(5):636-642.[12]龚广欣,杨坷,赵里曼.尿毒症性脑病的危险因素及相关炎症因子的预测价值[J].中国卫生检验杂志,2020,30(15):1905-1907.[13]Liu YM,Pan GHR.Research progress on the pathogenesis of acute lung injury in sepsis[J].hinese Journal of Difficult and Complicated Cases,2022,21(8):868-871,876.[14]于欢,张秀丽.外周血感染性指标IL-6联合NLR评估脓毒血症患者病情的临床价值[J].中国预防医学杂志,2022,21(10):1120-1124.[15]郑承全.系统免疫炎症指数联合预后营养指数在评价脓毒症患者病情及预后应用价值[D].南昌:昌大学,2022. [16]潘树滨,张芳晓,马晓春,等.中性粒细胞/淋巴细胞比值早期预测脓毒症器官功能损伤及28 d 病死率的临床价值[J].中华危重病急救医学,2021,33(6):665-670.[17]马占一,李传贵,张敬红,等.CRP、PCT、NLR联合检测预警输尿管结石发生尿源性脓毒血症的临床研究 [J].陆军军医大学学报,2022,44(6):589-594.[18]左扬松,周素芹,王丽莉,等.脓毒症相关急性肺损伤患者趋化因子受体4、可溶性髓样细胞触发受体样转录因子-1检测价值探讨[J].实用医院临床杂志,2023,20(6):84-86.[19]Wang Q,Liu K,Jin C.Clinical value of micro RNA-378a-3p in sepsis and its role in sepsis-induced inflammation and cardiac dysfunction[J].Bioengineered,2021,12(1):8496-8504.[20]奚耀,赵雷,钱风华,等.老年脓毒症患者红细胞分布宽度与病情程度的相关性[J].实用临床医药杂志,2021,25(16):112-115.

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更新日期/Last Update: 1900-01-01