[1]张德郁,潘盛强,李 宁.PI3K/Akt信号通路在中医药靶向骨关节炎中的应用研究[J].医学信息,2025,38(07):166-171.[doi:10.3969/j.issn.1006-1959.2025.07.034]
 ZHANG Deyu,PAN Shengqiang,LI Ning.Application of PI3K/Akt Signaling Pathway in Traditional Chinese Medicine Targeting Osteoarthritis[J].Journal of Medical Information,2025,38(07):166-171.[doi:10.3969/j.issn.1006-1959.2025.07.034]
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PI3K/Akt信号通路在中医药靶向骨关节炎中的应用研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年07期
页码:
166-171
栏目:
综述
出版日期:
2025-04-01

文章信息/Info

Title:
Application of PI3K/Akt Signaling Pathway in Traditional Chinese Medicine Targeting Osteoarthritis
文章编号:
1006-1959(2025)07-0166-06
作者:
张德郁1潘盛强1李 宁2
1.甘肃中医药大学中医临床学院,甘肃 兰州 730000;2.临洮县中医院骨伤科,甘肃 临洮 730500
Author(s):
ZHANG Deyu1 PAN Shengqiang1 LI Ning2
1.Clinical College of Traditional Chinese Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China;2.Department of Orthopedics and Traumatology, Lintao Hospital of Traditional Chinese Medicine, Lintao 730500, Gansu, China
关键词:
骨性关节炎PI3K/Akt信号通路中医药
Keywords:
Osteoarthritis PI3K/Akt signaling pathway Traditional Chinese medicine
分类号:
R684.3
DOI:
10.3969/j.issn.1006-1959.2025.07.034
文献标志码:
A
摘要:
骨关节炎(OA)是一种影响整个关节组织的复杂退行性疾病,目前尚未发现药物可以阻止或逆转软骨或骨丢失,除了手术治疗晚期骨性关节炎外,尚无有效的干预手段用以治疗骨性关节炎。临床与实验研究发现,中医药可通过参与PI3K/Akt信号通路来干预OA的发生进展,具体机制可能是通过激活膝关节免疫介导PI3K/Akt信号通路参与的炎性反应来调控膝关节软骨降解,软骨内稳态以及软骨细胞的功能特性,达到减轻滑膜水肿,降低炎症,促进软骨与成骨生长的目的。因此,PI3K/Akt信号通路为中医药干预OA提供了靶点与思路,但有关机制及系统论述相对较少,故基于PI3K/Akt信号通路,整理近年中药单体及复方对该通路的研究成果,以期为临床防治OA提供理论依据。
Abstract:
cartilage or bone loss. In addition to surgical treatment of advanced osteoarthritis, there is no effective intervention to treat osteoarthritis. Clinical and experimental studies have found that traditional Chinese medicine can interfere with the occurrence and progression of OA by participating in the PI3K/Akt signaling pathway. The specific mechanism may be to regulate the degradation of knee cartilage, cartilage homeostasis and functional characteristics of chondrocytes by activating the inflammatory response involved in the PI3K/Akt signaling pathway mediated by knee joint immunity, so as to reduce synovial edema, reduce inflammation and promote the growth of cartilage and osteogenesis. Therefore, the PI3K/Akt signaling pathway provides targets and ideas for traditional Chinese medicine to intervene in OA, but there are relatively few related mechanisms and systematic discussions. Therefore, based on the PI3K/Akt signaling pathway, the research results of traditional Chinese medicine monomers and compound prescriptions on this pathway in recent years are sorted out in order to provide a theoretical basis for clinical prevention and treatment of OA.

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更新日期/Last Update: 1900-01-01