[1]钟观连.小儿肺热咳喘口服液联合布地奈德雾化治疗儿童哮喘的临床效果及对临床症状的影响[J].医学信息,2025,38(17):121-125.[doi:10.3969/j.issn.1006-1959.2025.17.020]
　ZHONG Guanlian.Clinical Effect of Xiao’er Feire Kechuan Oral Liquid Combined with Budesonide Atomizationin the Treatment of Children with Asthma and its Influence on Clinical Symptoms[J].Journal of Medical Information,2025,38(17):121-125.[doi:10.3969/j.issn.1006-1959.2025.17.020]
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小儿肺热咳喘口服液联合布地奈德雾化治疗儿童哮喘的临床效果及对临床症状的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年17期
页码:
121-125
栏目:
论著
出版日期:
2025-09-01

文章信息/Info

Title:
Clinical Effect of Xiao’er Feire Kechuan Oral Liquid Combined with Budesonide Atomizationin the Treatment of Children with Asthma and its Influence on Clinical Symptoms
文章编号:
1006-1959（2025）17-0121-05
作者:
钟观连
萍乡市安源区妇幼保健院儿科门诊，江西 萍乡 337000
Author(s):
ZHONG Guanlian
Pediatric Outpatient, Pingxiang City Anyuan District Maternal and Child Health Hospital, Pingxiang 337000, Jiangxi, China
关键词:
小儿肺热咳喘口服液; 雾化; 哮喘; 布地奈德
Keywords:
Xiao’er Feire Kechuan oral liquid;  Atomization;  Asthma;  Budesonide
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2025.17.020
文献标志码:
A
摘要:
目的 分析小儿肺热咳喘口服液联合布地奈德雾化治疗儿童哮喘的临床效果及对临床症状的影响。方法 选取2021年5月-2024年2月萍乡市安源区妇幼保健院收治的66例哮喘患儿作为研究对象，并将其按照随机数字表法分为对照组和研究组，每组各33例。对照组使用吸入用布地奈德混悬液雾化吸入治疗，研究组在对照组基础上给予小儿肺热咳喘口服液口服治疗。比较两组临床效果、临床症状缓解时间（肺哮鸣音、咳嗽、憋喘缓解时间）、炎症因子水平[白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）和C反应蛋白（CRP）]、不良反应发生率（皮疹、头痛头晕、胃肠道不适）。结果 研究组治疗总有效率高于对照组（P＜0.05）。研究组临床症状缓解时间均低于对照组（P＜0.05）。治疗后，两组炎症因子水平均低于治疗前，且研究组炎症因子水平均低于对照组（P＜0.05）。研究组不良反应发生率低于对照组（P＜0.05）。结论 小儿肺热咳喘口服液联合雾化治疗儿童哮喘的临床效果确切，能够加快患儿临床症状改善，减轻患儿炎症反应，且安全性较高，值得临床应用。
Abstract:
Objective To analyze the clinical effect of Xiao’er Feire Kechuan Oral Liquid combined with budesonide atomization in the treatment of children with asthma and its influence on clinical symptoms. Methods A total of 66 children with asthma admitted to Pingxiang City Anyuan District Maternal and Child Health Hospital from May 2021 to February 2024 were selected as the research objects, and they were divided into control group and study group according to the random number table method, with 33 children in each group. The control group was treated with aerosol inhalation of budesonide suspension for inhalation, and the study group was treated with oral administration of Xiao’er Feire Kechuan oral liquid on the basis of the control group. The clinical effect, remission time of clinical symptoms (remission time of lung wheezing, cough and asthma), levels of inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP)] and incidence of adverse reactions (rash, headache and dizziness, gastrointestinal discomfort) were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). The remission time of clinical symptoms in the study group was lower than that in the control group (P<0.05). After treatment, the levels of inflammatory factors in the two groups were lower than those before treatment, and the levels of inflammatory factors in the study group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the study group was lower than that in the control group (P<0.05). Conclusion The clinical effect of Xiao’er Feire Kechuan oral liquid combined with atomization in the treatment of children with asthma is definite, which can accelerate the improvement of clinical symptoms and reduce the inflammatory response of children with high safety. It is worthy of clinical application.

参考文献/References:

[1]王文兰,张勤,许细财.玉屏风颗粒联合普米克令舒雾化吸入治疗儿童咳嗽变异性哮喘的疗效分析[J].浙江中医药大学学报,2023,47(1):58-63,68.[2]袁小霞,朱瑛.氧驱动雾化吸入治疗小儿支气管哮喘的临床护理干预策略分析[J].贵州医药,2022,46(6):1004-1005.[3]陈福将,吴超雄,何丽丹,等.吸入用复方异丙托溴铵溶液雾化吸入治疗儿童哮喘急性发作的临床研究[J].中国临床药理学杂志,2023,39(11):1523-1527.[4]李洪林,邓全敏.小儿咳喘灵颗粒联合布地奈德雾化吸入治疗咳嗽变异性哮喘的效果及安全性分析[J].中国国境卫生检疫杂志,2024,47(3):280-282.[5]黎鸣桃,黄淑芹,张可妃,等.细菌溶解产物胶囊联合布地奈德雾化吸入治疗对咳嗽变异性哮喘患儿免疫功能、气道功能的影响[J].临床和实验医学杂志,2023,22(2):175-179.[6]郑蕾芳,程纯,朱静.布地奈德联合特布他林及异丙托溴铵雾化吸入治疗急性发作期中度儿童哮喘临床研究[J].中国药业,2021,30(2):52-55.[7]李涛,张海波,唐静,等.沙丁胺醇、布地奈德辅助雾化吸入治疗小儿哮喘合并呼吸道病毒感染的疗效及预后观察[J].临床和实验医学杂志,2020,19(19):2070-2074.[8]鞠婧婧,李亚南,赵宇蕾,等.血浆维生素D水平与儿童哮喘的相关性及布地奈德、异丙托溴铵雾化吸入联合维生素D的治疗效果[J].实用心脑肺血管病杂志,2019,27(11):93-97.[9]杨会荣,刘建华,张培红,等.自拟平喘汤联合特布他林雾化吸入治疗急性发作期儿童支气管哮喘的疗效分析[J].中国现代医学杂志,2021,31(19):38-43.[10]陈爽花,刘文峰.布地奈德联合不同药物雾化吸入治疗儿童哮喘急性发作的疗效比较[J].浙江临床医学,2021,23(3):369-370.[11]祁海峰,张迎旭.布地奈德雾化剂联合重组人干扰素α-2b雾化吸入治疗小儿支气管哮喘对炎症因子表达的影响分析[J].贵州医药,2022,46(11):1724-1725.[12]王贞,辛丽红.沙丁胺醇、布地奈德辅助雾化吸入治疗小儿哮喘合并呼吸道病毒感染的疗效[J].中华生物医学工程杂志,2020,26(4):360-364.[13]朱元璐,黄琴,余忠红.复方异丙托溴铵联合不同剂量布地奈德混悬液雾化吸入治疗儿童变异性哮喘的临床研究[J].解放军医药杂志,2019,31(1):59-62,78.[14]方瑞,都鹏飞.特布他林联合布地奈德间歇雾化治疗儿童支气管哮喘的疗效观察[J].中国医院用药评价与分析,2019,19(8):953-955.[15]宋明媚,张海英.雾化吸入布地奈德联合酮替芬和脱敏疗法治疗儿童过敏性鼻炎哮喘综合征的效果[J].湖南师范大学学报(医学版),2021,18(2):243-246.[16]黄晓燕,陈积雄,罗海伶,等.孟鲁司特钠片联合布地奈德、沙丁胺醇、异丙托溴铵雾化吸入治疗支气管哮喘患儿的临床研究[J].解放军预防医学杂志,2019,37(8):125-126,129.[17]马莉娟.标准化干扰素α2b联合布地奈德混悬液治疗儿童支气管哮喘的效果和安全性评价[J].中国标准化,2023(16):285-288.[18]邱萌.维生素D滴剂辅助布地奈德雾化吸入治疗儿童支气管哮喘对炎症反应与气道重塑的影响[J].中国医院用药评价与分析,2020,20(11):1295-1299.[19]汪佩林,徐文付,徐双云,等.小儿肺热咳喘口服液联合布地奈德雾化吸入治疗小儿喘息性支气管炎的疗效及改善机体炎症反应和免疫力的效果研究[J].现代生物医学进展,2023,23(6):1165-1168,1189.[20]韩颖,蓝常肇,马少杰,等.小儿肺热咳喘口服液联合三联吸入雾化治疗法对哮喘急性发作的影响[J].现代生物医学进展,2020,20(6):1116-1119.

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更新日期/Last Update: 1900-01-01