[1]黎 云.宫颈环形电切术联合重组人干扰素α-2b凝胶治疗CIN伴高危型HPV感染的临床效果[J].医学信息,2026,39(02):128-132.[doi:10.3969/j.issn.1006-1959.2026.02.024]
　LI Yun.Clinical Effect of Loop Electrosurgical Excision Procedure Combined with RecombinantInterferon α-2b Gel in the Treatment of CIN with High-risk HPV Infection[J].Journal of Medical Information,2026,39(02):128-132.[doi:10.3969/j.issn.1006-1959.2026.02.024]
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宫颈环形电切术联合重组人干扰素α-2b凝胶治疗CIN伴高危型HPV感染的临床效果()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年02期
页码:
128-132
栏目:
临床证据信息
出版日期:
2026-01-15

文章信息/Info

Title:
Clinical Effect of Loop Electrosurgical Excision Procedure Combined with RecombinantInterferon α-2b Gel in the Treatment of CIN with High-risk HPV Infection
文章编号:
1006-1959（2026）02-0128-05
作者:
黎 云
武宁县妇幼保健院妇产科，江西 武宁 332300
Author(s):
LI Yun
Department of Obstetrics and Gynecology, Wuning County Maternal and Child Health Hospital, Wuning 332300, Jiangxi, China
关键词:
宫颈环形电切术; 重组人干扰素α-2b凝胶; CIN; 高危型HPV感染
Keywords:
Loop electrosurgical excision procedure;  Recombinant interferon α-2b gel;  CIN;  High-risk HPV infection
分类号:
R711
DOI:
10.3969/j.issn.1006-1959.2026.02.024
文献标志码:
A
摘要:
目的 评估宫颈环形电切术联合重组人干扰素α-2b凝胶在宫颈上皮内瘤变（CIN）伴高危型人乳头瘤病毒（HPV）感染治疗中的应用效果。方法 按照随机数字表法将武宁县妇幼保健院2022年5月-2024年4月诊治的48例CIN伴高危型HPV感染患者分为对照组24例和研究组24例。对照组行宫颈环形电切术治疗，研究组在对照组基础上采用重组人干扰素α-2b凝胶进行治疗。比较两组临床疗效、HPV阳性率、炎症指标水平（TNF-α、CRP、IL-4）、免疫功能（T淋巴细胞亚群CD4+、CD8+、CD4+/CD8+）。结果 研究组治疗总有效率高于对照组（P＜0.05）。治疗后，研究组HPV阳性率低于对照组（P＜0.05）。治疗后，研究组炎症指标水平均低于对照组（P＜0.05）。治疗后，研究组CD4+、CD4+/CD8+水平均高于对照组，而CD8+水平低于对照组（P＜0.05）。结论 宫颈环形电切术联合重组人干扰素α-2b凝胶治疗CIN伴高危型HPV感染患者的临床效果确切，能够抑制HPV感染发生，减轻患者炎症反应，改善患者免疫功能，临床应用价值较高。
Abstract:
Objective To analyze the clinical effect of loop electrosurgical excision procedure (LEEP) combined with recombinant interferon α-2b gel in the treatment of cervical intraepithelial neoplasia (CIN) with high-risk human papillomavirus (HPV) infection. Methods A total of 48 patients with CIN and high-risk HPV infection diagnosed and treated in Wuning County Maternal and Child Health Hospital from May 2022 to April 2024 were selected as the research objects. Using the random number table method, patients were assigned to either a control group or a study group, with 24 patients in each group. The control group was treated with loop electrosurgical excision procedure, and the study group was treated with recombinant human interferon α-2b gel on the basis of the control group. The clinical efficacy, HPV positive rate, inflammatory index levels (TNF-α, CRP, IL-4) and immune function (T lymphocyte subsets CD4+, CD8+, CD4+/CD8+) were compared between the two groups. Results The study group had a higher total effective rate than that in the control group (P<0.05). After treatment, the study group showed a significantly lower HPV-positive rate than that in the control group (P<0.05). After treatment, a significant reduction in inflammatory index levels was observed in the study group compared to the control group (P<0.05). After treatment, compared to the control group, the study group showed increased CD4+ levels and an elevated CD4+/CD8+ ratio, whereas CD8+ level was decreased (P<0.05). Conclusion Loop electrosurgical excision procedure combined with recombinant interferon α-2b gel has a definite clinical effect in the treatment of CIN patients with high-risk HPV infection, which can inhibit the occurrence of HPV infection, reduce the inflammatory response of patients, improve their immune function, and has high clinical application value.

参考文献/References:

[1]秦燕萍,杜鹏,杨丽芳.LEEP联合重组人干扰素α-2b凝胶治疗宫颈上皮内瘤变的疗效及对患者免疫功能的影响[J].中国性科学,2020,29(5):29-32.[2]弋文娟,蒋洪昆,陈煜岊,等.膦甲酸钠联合重组人干扰素用于高级别宫颈上皮内瘤变伴高危型HPV感染患者宫颈环形电切术后临床研究[J].中国性科学,2019,28(12):125-129.[3]张佳珍.LEEP术后干扰素凝胶联合保妇康栓对CINⅢ患者疗效及炎症因子水平的影响[J].中国计划生育学杂志,2019,27(5):608-611.[4]林琳,傅亚均.宫颈上皮内瘤变Ⅰ级合并高危型HPV感染行宫颈环形电切术与聚焦超声治疗的疗效对比[J].传染病信息,2018,31(4):368-371.[5]张艳,杜然,张娴,等.光动力治疗宫颈环形电切术后宫颈低级别鳞状上皮内病变合并高危型人乳头瘤病毒感染的疗效分析[J].中国医师杂志,2023,25(9):1377-1380.[6]刘娟,杨丽.宫颈上皮内瘤变合并人乳头瘤病毒感染患者宫颈环形电切术后的病原菌分布炎症因子水平变化及临床意义[J].山西医药杂志,2022,51(17):1934-1938.[7]张菲菲,高广云,张海燕,等.宫颈上皮内瘤变患者宫颈环形电切术后HPV持续感染的高危因素分析及其对阴道微生态和免疫调节功能的影响[J].现代生物医学进展,2022,22(15):2854-2859.[8]刘静云,吕志红,徐芳,等.微管蛋白及P16蛋白在宫颈上皮内瘤变Ⅱ～Ⅲ级患者宫颈环形电切术后复发预测模型的应用分析[J].中国医学装备,2022,19(6):101-105.[9]吴婉如,邓勍,张翠雯.宫颈环形电切术联合重组人干扰素a2b对宫颈鳞状上皮内瘤变患者疗效及对阴道微生态的影响[J].河北医学,2022,28(12):2081-2086.[10]杨滢,尹家瑶,张小雪.宫颈环形电切术辅以保妇康栓治疗慢性重度宫颈炎伴宫颈上皮内瘤样病变Ⅰ、Ⅱ级患者效果及对预后影响[J].临床误诊误治,2021,34(3):91-96.[11]冯美宁,郜欣.宫颈环形电切术后应用重组干扰素α-2b栓治疗高危型人乳头瘤病毒感染宫颈上皮内瘤变的效果[J].中国肿瘤临床与康复,2020,27(5):552-555.[12]吴华长,高春元,叶礼翠.LEEP锥切术联合雌激素补充治疗围绝经期HPV阳性低度宫颈上皮内瘤变临床效果[J].中国计划生育学杂志,2022,30(11):2543-2546.[13]程芙蓉,冯陆志,李海生.宫颈多点活检+宫颈管搔刮术与宫颈环形电切术在宫颈上皮内瘤变诊断及病理分级中的应用价值[J].中国妇幼保健,2018,33(14):3336-3339.[14]杨雨露,姚玉琴,张苗,等.聚焦超声与子宫颈环形电切术治疗子宫颈高级别鳞状上皮内病变疗效研究[J].中国实用妇科与产科杂志,2023,39(12):1241-1244.[15]周佳怡,张跃明,何静,等.高级别宫颈鳞状上皮内病变患者宫颈锥切术后高危型人乳头瘤病毒持续感染的相关因素分析[J].肿瘤预防与治疗,2021,34(5):408-413.[16]李红,杨元娟,王耀楷,等.宫颈高级别鳞状上皮内病变及以上患者LEEP术后切缘状态与病变残留的关系分析[J].湖南师范大学学报(医学版),2022,19(5):122-126.[17]陈见美,符永帅,周冬梅,等.宫颈冷刀锥切术治疗宫颈上皮内瘤变的疗效观察及术后切缘阳性的危险因素分析[J].现代生物医学进展,2020,20(1):135-139.[18]姚丽.LEEP联合派特灵治疗宫颈上皮内瘤样病变及高危型HPV感染疗效及对患者感染清除率、微生态环境相关免疫因子的影响[J].陕西医学杂志,2018,47(8):994-996.[19]李寅红,刘铭兰,季滢.LEEP联合干扰素对宫颈上皮内瘤变患者免疫功能和高危型HPV DNA表达的影响[J].医学临床研究,2019,36(10):2061-2062.[20]孟丽,张迪,张海蓉.宫颈上皮内瘤变患者LEEP术前后人乳头状瘤病毒负荷与疾病预后的关系研究[J].中国肿瘤临床与康复,2018,25(11):1297-1299.

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更新日期/Last Update: 1900-01-01