[1]李 科.骨形态发生蛋白4与乳腺癌骨转移的相关性研究[J].医学信息,2018,31(13):17-20.[doi:10.3969/j.issn.1006-1959.2018.13.005]
　LI Ke.Relationship between Bone Morphogenetic Protein 4 and Bone Metastasis in Breast Cancer[J].Journal of Medical Information,2018,31(13):17-20.[doi:10.3969/j.issn.1006-1959.2018.13.005]
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骨形态发生蛋白4与乳腺癌骨转移的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年13期
页码:
17-20
栏目:
出版日期:
2018-07-01

文章信息/Info

Title:
Relationship between Bone Morphogenetic Protein 4 and Bone Metastasis in Breast Cancer
文章编号:
1006-1959（2018）13-0017-04
作者:
李 科
四川中医药高等专科学校第一附属医院/绵阳富临医院普外科，四川 绵阳 621000
Author(s):
LI Ke
The First Affiliated Hospital of Sichuan College of Traditional Chinese Medicine/General Surgery,Mianyang Fulin Hospital,Mianyang 621000,Sichuan,China
关键词:
BMP-4; 乳腺肿瘤; 骨转移; 免疫组织化学
Keywords:
Key words：BMP-4; Breast tumor; Bone metastasis; immunohistochemistry
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2018.13.005
文献标志码:
A
摘要:
目的 探讨乳腺癌组织及癌旁正常乳腺组织中骨形态发生蛋白4的表达情况，分析BMP-4表达水平与乳腺癌骨转移的相关性。方法 收集自2003年1月~2016年12月绵阳富临医院乳腺外科乳腺癌患者术后病理标本，其中228例乳腺癌组织石蜡标本，40例癌旁2 cm正常组织石蜡标本作为对照。应用免疫组织化学检测BMP-4蛋白在癌组织和癌旁正常组织中的表达情况。结果 BMP-4在有骨转移乳腺癌组织、无骨转移乳腺癌组织及癌旁正常组织阳性表达率分别为11.90%（5/42）,39.78%（74/186）, 45.00%（18/40）。发生骨转移乳腺癌组织中BMP-4阳性表达率较无骨转移的乳腺癌组织、癌旁正常组织明显降低，差异有统计学意义(P＜0.05)。结论 BMP-4表达水平降低与乳腺癌骨转移相关,BMP-4阳性表达的患者较BMP-4阴性表达的患者骨转移发生几率低。
Abstract:
Abstract：Objective To investigate the expression of bone morphogenetic protein-4 in breast cancer tissues and adjacent normal breast tissues,and to analyze the correlation between BMP-4 expression level and bone metastasis of breast cancer.Methods The postoperative pathological specimens of breast cancer patients from Mianyang Fulin Hospital in Mianyang from January 2003 to December 2016 were collected.Among them,228 specimens of breast cancer tissue and 40 paraffin specimens of 2 cm adjacent normal tissues were used as controls.Immunohistochemistry was used to detect the expression of BMP-4 protein in cancer tissues and adjacent normal tissues.Results The positive expression rates of BMP-4 in breast cancer tissues, bone metastasis-free breast cancer tissues and adjacent normal tissues were 11.90%(5/42),39.78% (74/186),and 45.00%(18/40),respectively.The positive expression rate of BMP-4 in breast cancer tissues with bone metastasis was significantly lower than that in breast cancer tissues without adjacent bone metastasis,and the difference was statistically significant(P<0.05).Conclusion Decreased expression of BMP-4 is associated with bone metastasis in breast cancer,and patients with positive BMP-4 expression have a lower incidence of bone metastases than patients with negative BMP-4 expression.

参考文献/References:

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更新日期/Last Update: 2018-07-01