[1]季士亮.药物致剥脱性皮炎的临床分析[J].医学信息,2018,31(18):112-114.[doi:10.3969/j.issn.1006-1959.2018.18.035]
　JI Shi-liang.Clinical Analysis of Drug-induced Exfoliative Dermatitis[J].Journal of Medical Information,2018,31(18):112-114.[doi:10.3969/j.issn.1006-1959.2018.18.035]
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药物致剥脱性皮炎的临床分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年18期
页码:
112-114
栏目:
调查分析
出版日期:
2018-09-15

文章信息/Info

Title:
Clinical Analysis of Drug-induced Exfoliative Dermatitis
文章编号:
1006-1959（2018）18-0112-03
作者:
季士亮1; 2
1.苏州科技城医院临床药学室，江苏 苏州 215000； 2.南京医科大学附属苏州医院，江苏 苏州 215000
Author(s):
JI Shi-liang1; 2
1.Clinical Pharmacy Room,Suzhou Science and Technology Town Hospital,Suzhou 215000,Jiangsu,China; 2.Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215000,Jiangsu,China
关键词:
药物不良反应; 剥脱性皮炎型药疹; 药学监护
Keywords:
Key words：Adverse drug reaction; Exfoliative dermatitis eruption; Pharmaceutical monitoring
分类号:
R758.25
DOI:
10.3969/j.issn.1006-1959.2018.18.035
文献标志码:
A
摘要:
目的 调查药源性剥脱性皮炎的发生特点及诊疗方法，为临床合理用药提供参考。方法 计算机检索中国知网、万方数据库、PubMed、Embase电子数据库有关药物致剥脱性皮炎的不良反应文献并结合手工检索不良反应网站，检索时间为2000~2018年，查阅药物型剥脱性皮炎的病例报道。按照相关项目录入SPSS22.0对性别、年龄以及药物品种、类别、给药途径等用药情况进行统计分析。结果 共查阅药物型剥脱性皮炎报道285篇，文献中包含病例320例，其中男性占60.30%，女性占38.13%，男性发病率高于女性，差异有统计学意义（P＜0.05）；年龄分布以成年人为主；其中有63.75%的患者存在药物过敏史或皮肤病史；大部分患者的症状能在1个月内得到控制或治愈。结论 药物致剥脱性皮炎与性别有一定的关联性，且患者预先存在的皮肤病及其治疗可能是引起ED发生的主要原因。
Abstract:
Abstract：Objective To investigate the occurrence characteristics and diagnosis and treatment methods of drug-induced exfoliative dermatitis,and provide reference for clinical rational drug use.Methods Computers were searched for the adverse reactions of drug-induced exfoliative dermatitis in China Knowledge Network,Wanfang Database,PubMed,and Embase electronic databases,and combined with manual retrieval of adverse reaction sites.The search time was as 2000 to 2018,and the case report of drug-type exfoliative dermatitis was reviewed.According to the relevant items,SPSS22.0 was used to analyze the sex,age,drug type,category,and route of administration.Results A total of 285 cases of drug-type exfoliative dermatitis were reported.There were 320 cases in the literature,including 60.30% of males and 38.13% of females.The male incidence rate was higher than that of females,the difference was statistically significant(P<0.05);age distribution adults are the main;63.75% of them have a history of drug allergy or skin history; most patients can be controlled or cured within 1 month.Conclusion Drug-induced exfoliative dermatitis has a certain correlation with gender,and pre-existing skin diseases and treatment may be the main cause of ED.

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更新日期/Last Update: 2018-09-15