[1]张艳萍,曹 玉,孙国平.服用阿司匹林对乳腺癌患者生存获益的Meta分析[J].医学信息,2018,31(20):72-77.[doi:10.3969/j.issn.1006-1959.2018.20.021]
　ZHANG Yan-ping,CAO Yu,SUN Guo-ping.Meta Analysis of the Survival Benefit of Patients with Breast Cancer Treated with Aspirin[J].Medical Information,2018,31(20):72-77.[doi:10.3969/j.issn.1006-1959.2018.20.021]
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服用阿司匹林对乳腺癌患者生存获益的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年20期
页码:
72-77
栏目:
论著
出版日期:
2018-10-15

文章信息/Info

Title:
Meta Analysis of the Survival Benefit of Patients with Breast Cancer Treated with Aspirin
文章编号:
1006-1959（2018）20-0072-06
作者:
张艳萍; 曹 玉; 孙国平
安徽医科大学第一附属医院全科医学科，安徽 合肥 230022
Author(s):
ZHANG Yan-ping; CAO Yu; SUN Guo-ping
Department of General Medicine,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China
关键词:
乳腺癌; 阿司匹林; 预后; Meta分析
Keywords:
Breast cancer; Aspirin; Prognosis; Meta-analysis
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2018.20.021
文献标志码:
A
摘要:
目的 采用Meta分析探讨服用阿司匹林是否改善乳腺癌患者的预后。方法 检索PubMed、EMBASE、CNKI等中外数据库中关于服用阿司匹林与乳腺癌预后关系的文献，时间截止至2018年3月，提取全因死亡及乳腺癌特异死亡的相关结果进行效应量的合并，对纳入的数据进行敏感性分析、发表偏倚分析等。所有统计分析均采用Stata12.0软件完成。结果 共纳入11篇文献，其中包括9篇队列研究及2篇巢式病例对照研究，共计乳腺癌患者36862例。Meta分析结果显示，诊断前服用阿司匹林的乳腺癌患者与未服用的患者相比，无论是总死亡率（HR=1.06，95%CI=0.78~1.43）还是肿瘤特异死亡率（HR=1.06，95%CI=0.66~1.69）均无显著改善。诊断后服用阿司匹林并不能降低乳腺癌患者的总死亡率（HR=0.84，95%CI=0.64~1.11），但可降低肿瘤特异死亡率（HR=0.73，95%CI=0.55~0.98）。对纳入文献进行敏感性分析，结果显示，诊断后服用阿司匹林并不能降低肿瘤特异死亡率（HR=0.95，95%CI=0.85~1.06）。结论 服用阿司匹林对改善乳腺癌患者的死亡率无显著作用。
Abstract:
Objective To investigate whether taking aspirin improves the prognosis of breast cancer patients by meta-analysis. Methods The literatures on the relationship between aspirin and breast cancer prognosis in PubMed,EMBASE,CNKI and other Chinese and foreign databases were searched.The results of the combination of all-cause death and breast cancer-specific death were combined until March 2018.The data is subjected to sensitivity analysis,publication bias analysis,and the like.All statistical analyses were performed using Stata 12.0 software.Results A total of 11 articles were included,including 9 cohort studies and 2 nested case-control studies,with a total of 36,862 breast cancer patients.Meta analysis showed that there was no significant improvement in total mortality(HR=1.06,95%CI=0.78~1.43)or tumor specific mortality(HR=1.06,95%CI=0.66~1.69)in patients with breast cancer who took aspirin before diagnosis compared with those who did not.Taking aspirin after diagnosis did not reduce the overall mortality of breast cancer patients(HR=0.84,95%CI=0.64~1.11),but reduced tumor-specific mortality(HR=0.73,95%CI=0.55~0.98).Sensitivity analysis of the included literature showed that taking aspirin after diagnosis did not reduce tumor-specific mortality(HR=0.95,95%CI=0.85~1.06). Conclusion Taking aspirin has no significant effect on improving mortality in breast cancer patients.

参考文献/References:

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更新日期/Last Update: 2018-11-09