[1]张雅静,卢树军,齐庆玲.右美托咪定预充对体外循环下心脏手术患者肾功能的影响[J].医学信息,2018,31(20):131-133.[doi:10.3969/j.issn.1006-1959.2018.20.039]
　ZHANG Ya-jing,LU Shu-jun,QI Qing-ling.Effect of Dexmedetomidine Prefilled on Renal Function in Patients undergoing Cardiac Surgery under Cardiopulmonary Bypass[J].Medical Information,2018,31(20):131-133.[doi:10.3969/j.issn.1006-1959.2018.20.039]
点击复制

右美托咪定预充对体外循环下心脏手术患者肾功能的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年20期
页码:
131-133
栏目:
药物与临床
出版日期:
2018-10-15

文章信息/Info

Title:
Effect of Dexmedetomidine Prefilled on Renal Function in Patients undergoing Cardiac Surgery under Cardiopulmonary Bypass
文章编号:
1006-1959（2018）20-0131-03
作者:
张雅静1; 卢树军2; 齐庆玲1
1.天津中医药大学第一附属医院麻醉科，天津 300000；2.天津市第一中心医院，天津 300192
Author(s):
ZHANG Ya-jing1; LU Shu-jun2; QI Qing-ling1
1.Department of Anesthesiology,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China;2.Tianjin First Central Hospital,Tianjin 300192,China
关键词:
右美托咪定; 体外循环; 预充液; 肾功能
Keywords:
Dexmedetomidine; Cardiopulmonary bypass; Prefilled; Renal function
分类号:
R614
DOI:
10.3969/j.issn.1006-1959.2018.20.039
文献标志码:
A
摘要:
目的 探讨体外循环过程中，预充右美托咪定对心脏手术患者肾功能的影响。方法 2014年1月~2017年1月于天津市第一中心医院择期行CPB心脏直视手术患者86例，随机分为对照组（C组）与观察组（D组），各43例。D组预充液加右美托咪定注射液1 μg/kg，C组预充液加等量生理盐水。在转机前（T0），转机后10 min（T1），升主动脉阻断后10 min（T2），升主动脉开放后10 min（T3），CPB结束后（T4）抽取血样检测NGAL、Cys-C和β2-MG；在各时间点经食道超声监测两组患者肾动脉内径、肾动脉平均血流速度和肾血流量。结果 ①与T0比较，T3、T4时两组患者NGAL均升高，差异有统计学意义（P＜0.05）；T4时C组NGAL水平高于D组，差异有统计学意义（P＜0.05）；②与T0比较，T3、T4时两组患者Cys-C均升高，差异有统计学意义（P＜0.05）；但两组间Cys-C水平各时间点比较，差异无统计学意义（P＞0.05）；③与T0比较，T2、T3和T4两组β2-MG均升高，差异有统计学意义（P＜0.05）；且T2、T3和T4时，D组患者β2-MG水平均低于C组，差异有统计学意义（P＜0.05）；④D组患者动脉平均血流速度在T3、T4时均高于T0时，差异有统计学意义（P＜0.05），肾血流量在T2、T3和T4时均高于T0时，差异有统计学意义（P＜0.05）；T3、T4时刻，D组患者肾动脉平均血流速度均高于C组，差异有统计学意义（P＜0.05）； T2、T3和T4时刻，D组患者肾血流量均高于C组，差异有统计学意义（P＜0.05）。结论 右美托咪定对CPB下心脏手术围术期肾功能具有保护作用，可有效抑制肾脏损伤，维持肾血流动力学稳定，提高围术期安全性。
Abstract:
Varicocele is a common male reproductive system disease that is an important cause of male infertility.At present,there are many treatment methods for clinical application,and different treatment methods are applicable to different types of patients and e

参考文献/References:

[1]SHI Qiu-xia,HAN Dan-nuo,JIA Ming,et al.Risk factors of acute kidney injury after cardiopulmonary bypass[J].Chinese Journal of Evidence-Bases Cardiovascular Medicine,2017(4):452-455.[2]Gaffney AM,Sladen RN.Acute kidney injury in cardiac surgery[J].Curr Opin Anaesthesiol,2015,28(1):50-59.[3]Sato Y,Kato TS,Oishi A,et al.Preoperative Factors Associated With Postoperative Requirements of Renal Replacement Therapy Following Cardiac Surgery[J].Am J Cardiol,2015,116(2):294-300.[4]Borthwick E,Ferguson A.Perioperative acute kidney injury: risk factors,recognition,management,and outcomes[J].BMJ,2010( 341):c3365.[5]Englberger L,Suri RM,Greason KL,et al.Deep hypothermic circulatory arrest is not a risk factor for acute kidney injury in thoracic aortic surgery[J].J Thorac Cardiovasc Surg,2011(141):552-558.[6]张慧,张涛元,王淼,等.联合瓣膜置换术后急性肾损伤发生的相关危险因素研究[J].中国体外循环杂志,2017,15(3):148-152.[7]Zhai M,Kang F,Han M,et al.The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass:A double-blind randomized controlled trial[J].J Journal of Clinical Anesthesia,2017(40):33-38.

相似文献/References:

[1]黄 勃.心脏手术后并发急性肾功能损伤的研究进展[J].医学信息,2018,31(03):52.[doi:10.3969/j.issn.1006-1959.2018.03.017]
　HUANG Bo.Progress in the Study of Acute Renal Injury after Cardiac Surgery[J].Medical Information,2018,31(20):52.[doi:10.3969/j.issn.1006-1959.2018.03.017]
[2]杨进斌,韩建阁.右美托咪定复合丙泊酚和芬太尼在无痛人流术中的应用观察[J].医学信息,2018,31(03):134.[doi:10.3969/j.issn.1006-1959.2018.03.047]
　YANG Jin-bin,HAN Jian-ge.Application of Dexmetomidine Combined with Propofol and Fentanyl in Painless Induced Abortion[J].Medical Information,2018,31(20):134.[doi:10.3969/j.issn.1006-1959.2018.03.047]
[3]侯 江.舒芬太尼联合右美托咪定用于临床麻醉的效果观察[J].医学信息,2018,31(03):144.[doi:10.3969/j.issn.1006-1959.2018.03.051]
　HOU Jiang.Clinical Observation on the Effect of Sufendate Combined with Dexlansoprazole in Clinical Anesthesia[J].Medical Information,2018,31(20):144.[doi:10.3969/j.issn.1006-1959.2018.03.051]
[4]陶 晶,王 鑫,黄 擘,等.右美托咪定对截肢术后发生谵妄的疗效观察[J].医学信息,2018,31(04):123.[doi:10.3969/j.issn.1006-1959.2018.04.043]
　TAO Jing,WANG Xin,HUANG Bo,et al.Therapeutic Effect of Dexmedetomidine on Delirium after Amputation[J].Medical Information,2018,31(20):123.[doi:10.3969/j.issn.1006-1959.2018.04.043]
[5]江亚楠,梁永新,施彩凤,等.右美托咪定在大鼠脊髓缺血再灌注损伤中的 保护作用及机制研究[J].医学信息,2018,31(07):69.[doi:10.3969/j.issn.1006-1959.2018.07.022]
　JIANG Ya-nan,LIANG Yong-xin,SHI Cai-feng,et al.Protective Effects and Mechanism of Dexmedetomidine on Spinal Cord Ischemia-Reperfusion Injury in Rats[J].Medical Information,2018,31(20):69.[doi:10.3969/j.issn.1006-1959.2018.07.022]
[6]孙素花,宋建防,褚海辰,等.右美托咪定经鼻给药在胸腔镜肺叶切除术中的疗效观察[J].医学信息,2018,31(07):78.[doi:10.3969/j.issn.1006-1959.2018.07.025]
　SUN Su-hua,SONG Jian-fang,CHU Hai-chen,et al.Efficacy of Dexmetomidine in Thoracoscopic Lobectomy by Nasal Administration[J].Medical Information,2018,31(20):78.[doi:10.3969/j.issn.1006-1959.2018.07.025]
[7]王绪飞,梁永新.右美托咪定复合布比卡因骶管阻滞对预防七氟醚 小儿麻醉苏醒期躁动的观察分析[J].医学信息,2018,31(08):78.[doi:10.3969/j.issn.1006-1959.2018.08.024]
　WANG Xu-fei,LIANG Yong-xin.Observation of Dexmedetomidine Combined with Bupivacaine Caudal Block in Preventing Sedation in Children with Sevoflurane during Anesthesia Recovery Period[J].Medical Information,2018,31(20):78.[doi:10.3969/j.issn.1006-1959.2018.08.024]
[8]李 璟,蒋 娜,王晶晶,等.右美托咪定对H9C2心肌细胞缺氧/复氧损伤的保护作用[J].医学信息,2018,31(09):83.[doi:10.3969/j.issn.1006-1959.2018.09.025]
　LI Jing,JIANG Na,WANG Jing-jing,et al.Protective Effects of Dexmedetomidine on Hypoxia/Reoxygenation Injury in H9C2 Cardiomyocytes[J].Medical Information,2018,31(20):83.[doi:10.3969/j.issn.1006-1959.2018.09.025]
[9]赵 亮,王绍林.右美托咪定滴鼻和七氟烷吸入对患儿麻醉前镇静和 苏醒后躁动的影响[J].医学信息,2018,31(10):124.[doi:10.3969/j.issn.1006-1959.2018.10.040]
　ZHAO Liang,WANG Shao-lin.Effects of Dexmedetomidine Dripping and Seven Halothane Inhalation on Sedation and Recovery Agitation after Anesthesia in Children[J].Medical Information,2018,31(20):124.[doi:10.3969/j.issn.1006-1959.2018.10.040]
[10]疏 腾,胡胜红,叶 慧,等.静脉输注右美托咪定对甲状腺切除手术患者术后恢复质量的影响[J].医学信息,2022,35(09):161.[doi:10.3969/j.issn.1006-1959.2022.09.041]
　SHU Teng,HU Sheng-hong,YE Hui,et al.Effect of Intravenous Infusion of Dexmedetomidine on Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery[J].Medical Information,2022,35(20):161.[doi:10.3969/j.issn.1006-1959.2022.09.041]
[11]朱金伟,刘 聪,刘忠民,等.右美托咪定对体外循环术后患者的心脏保护作用的研究[J].医学信息,2019,32(08):4.[doi:10.3969/j.issn.1006-1959.2019.08.002]
　ZHU Jin-wei,LIU Cong,LIU Zhong-min,et al.Cardiac Protective Effect of Dexmedetomidine on Patients after Cardiopulmonary Bypass[J].Medical Information,2019,32(20):4.[doi:10.3969/j.issn.1006-1959.2019.08.002]
[12]刘丽丽.右美托咪定联合舒芬太尼对体外循环心脏瓣膜置换术患者围术期器官保护及术后认知功能的影响[J].医学信息,2022,35(17):95.[doi:10.3969/j.issn.1006-1959.2022.17.025]
　LIU Li-li.Effects of Dexmedetomidine Combined with Sufentanil on Perioperative Organ Protection and Postoperative Cognitive Function in Patients Undergoing Cardiopulmonary Bypass Cardiac Valve Replacement[J].Medical Information,2022,35(20):95.[doi:10.3969/j.issn.1006-1959.2022.17.025]

更新日期/Last Update: 2018-11-09