[1]陈 鹏,吴 楠,葛俊君,等.地衣芽胞杆菌联合幽门螺旋杆菌补救疗法的临床观察[J].医学信息,2018,31(23):114-116.[doi:10.3969/j.issn.1006-1959.2018.23.031]
　CHEN Peng,WU Nan,GE Jun-jun,et al.Clinical Observation of Bacillus Licheniformis Combined with H.pylori Salvage Therapy[J].Journal of Medical Information,2018,31(23):114-116.[doi:10.3969/j.issn.1006-1959.2018.23.031]
点击复制

地衣芽胞杆菌联合幽门螺旋杆菌补救疗法的临床观察()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年23期
页码:
114-116
栏目:
临床研究
出版日期:
2018-12-01

文章信息/Info

Title:
Clinical Observation of Bacillus Licheniformis Combined with H.pylori Salvage Therapy
文章编号:
1006-1959（2018）23-0114-03
作者:
陈 鹏1; 吴 楠1; 葛俊君1; 杨秋燕1; 陈 曦2
1.上海长征医院南京分院消化科，江苏 南京 210011；2.解放军第八一医院消化科，江苏 南京 210002
Author(s):
CHEN Peng1;  WU Nan1; GE Jun-jun1; YANG Qiu-yan1; CHEN Xi2
1.Department of Gastroenterology,Nanjing Branch of Shanghai Changzheng Hospital,Nanjing 210011,Jiangsu,China;2.Department of Gastroenterology,No. 81 Hospital of PLA,Nanjing 210002,Jiangsu,China
关键词:
地衣芽胞杆菌; 幽门螺旋杆菌; 补救疗法
Keywords:
Bacillus licheniformis; H.pylori; Hp; Remedial therapy
分类号:
R57
DOI:
10.3969/j.issn.1006-1959.2018.23.031
文献标志码:
A
摘要:
探讨地衣芽胞杆菌联合幽门螺旋杆菌补救治疗的临床疗效及不良反应。方法 将胃镜及呼气试验确认的Hp感染者予标准三联疗法治疗清除2周，4周后复查Hp，采用随机数字表法将202例首次清除Hp失败者分为地衣芽胞杆菌联合补救疗法的观察组（n=102）和非联合疗法的对照组（n=100），对比分析根治率及不良反应率；结果 观察组根治率优于对照组（89.13% vs 80.65%），但差异无统计学意义（P＞0.05），不良反应发生率低于对照组（5.43% vs 19.35%），差异有统计学意义（P＜0.05）；结论 地衣芽孢杆菌联合补救疗法清除HP不能加强根治效果，但可以减少药物引起的不良反应。
Abstract:
Objective To investigate the clinical efficacy and adverse reactions of Bacillus licheniformis combined with H.pylori，Hp. Methods Hp patients diagnosed by gastroscopy and breath test were treated with standard triple therapy for 2 weeks, and Hp, was rechecked 4 weeks later. 202 cases Hp losers were randomly divided into two groups: observation group (n=102) treated with Bacillus licheniformis combined with rescue therapy and control group (n=100) without combined therapy. The curative rate and adverse reaction rate were compared and analyzed. Results The radical cure rate of the observation group was better than that of the control group (89.13% vs 80.65%), but the difference was not statistically significant (P>0. 05), and the incidence of adverse reactions was lower than that of the control group (5.43% vs 19.35%),the difference was statistically significant (P<0.05).Conclusion The removal of HP by Bacillus licheniformis combined with rescue therapy can not strengthen the curative effect, but can reduce the adverse reaction caused by drugs.

参考文献/References:

[1]Winter JA,Letley DD,Cook KW,et al.A role for the vac-uolating cytotoxin,VacA,in colonization and Helicobac-ter pylori-induced metaplasia in the stomach[J].J Infect Dis,2014,210(6):954-963.
[2]Sugano K,Tack J,Kuipers EJ,et al.Kyoto global consensus report An Helicobacter pylori gastritis[J].Gut,2015,64(9):1353-1367.
[3]李欢,龙辉,吴清明.益生菌联合健康教育对提高幽门螺杆菌根除率的作用[J].临床内科杂志,2017,8 (34):561-562.
[4]漆小龙,李可.益生菌在幽门螺杆菌根除治疗中的研究进展[J].胃肠病学,2016,21(10):633-636.
[5]Liuba P,Pesome E.Infection and early atherosclerosis does the evidence support causation[J].Acta Paediatr,2005,94(6):643-651.
[6]Sugano K,Tack J,Kuipers EJ,et al.faculty members of Kyoto Global Consensus Conference.Kyoto global consensus report on Helicobacter pylori gastritis[J].Gut,2015,64(9):1353-1367.
[7]Fallone CA,Chiba N,van Zanten SV,et al.The Toronto Consensus for the Treatment of Helicobacter pylori Infection in Adults[J].Gastroenterology,2016,151(1):51-69.
[8]Malfertheiner P,Megraud F,O'Morain CA,et al.European Helicobacter and Microbiota Study Group and Consensus panel.Management of Helicobacter pylori infection-the MaastrichtV/Florence Consensus Report[J].Gut,2017,66(1):6-30.
[9]中华医学会消化病学分会幽门螺杆菌学组.幽门螺杆菌胃炎京都全球共识研讨会纪要[J].中华消化杂志.2016,36(1):53-57.
[10]陈淑萍,王磊,余建奎.益生菌联合三联疗法根除幽门螺杆菌的临床研究[J].中华临床感染病杂志，2012,2(4):98-100.
[11]Nam H,Ha M,Bae O,et al.Effect of Weissecca confuse strain PL9001 on the adherence and growth of Helicobacter pylori[J].Appl Environ Microbiol,2005,68(19):4642-4645.
[12]Lu C,Sang J,He H,et al.Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy:a meta analysis [J].Sci Rep,2016(6):23522.
[13]杜琼芳,蒋永爱,王建宁,等.微生态制剂在十二指肠球部溃疡伴Hp感染治疗中的应用[J].医药导报,2015,34(8):31-33.
[14]任乃刚,陈伟,彭勃.整肠生的作用机理及临床应用[J].中国临床药理学杂志,2013(9):716-717.
[15]Malfertheiner P,Megraud F,0'Morain CA,et al.Management of helicobacter pylori infection -the maastricht IV/Mlorence consensus report[J].Gut,2012,61(5):646-664.
[16]边佳昕,闵涛玲,陈昌发,等.益生菌用于疾病治疗的研究进展[J].世界临床药物,2017,38(2):134-137.
[17]Kamiya T,Wang L,Forsythe P,et al.Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats[J].Gut,2006,55(2): 191-196.
[18]Rousseaux C,Thuru X,Gelot A,et al.Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors[J].Nat Med,2007,13(1):35-37.

相似文献/References:

[1]邱梦君,郑国荣.大黄、黄连、黄芩联合三联序贯治疗Hp感染的疗效分析[J].医学信息,2018,31(06):137.[doi:10.3969/j.issn.1006-1959.2018.06.047]
　QIU Meng-jun,ZHENG Guo-rong.Curative Effect Analysis of Sequential Treatment of Hp Infection by Rhubarb,Coptis Chinensis and Radix Scutellariae[J].Journal of Medical Information,2018,31(23):137.[doi:10.3969/j.issn.1006-1959.2018.06.047]
[2]夏 铭,张正坤,曾海龙,等.四种疗法治疗幽门螺杆菌阳性消化性溃疡疗效分析[J].医学信息,2018,31(11):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
　XIA Ming,ZHANG Zheng-kun,ZENG Hai-long,et al.Therapeutic Effect of Four Kinds of Therapy on Helicobacter Pylori Positive Peptic Ulcer[J].Journal of Medical Information,2018,31(23):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
[3]侯拂晓.四联疗法治疗幽门螺旋杆菌相关性十二指肠球炎疗效分析[J].医学信息,2018,31(17):135.[doi:10.3969/j.issn.1006-1959.2018.17.042]
　HOU Fu-xiao.Therapeutic Effect of Quadruple Therapy on Helicobacter pylori Associated Duodenal Inflammation[J].Journal of Medical Information,2018,31(23):135.[doi:10.3969/j.issn.1006-1959.2018.17.042]
[4]谢迎新.复方嗜酸乳杆菌联合常规四联疗法治疗幽门螺旋杆菌感染消化性溃疡的疗效[J].医学信息,2020,33(02):138.[doi:10.3969/j.issn.1006-1959.2020.02.040]
　XIE Ying-xin.Effect of Compound Lactobacillus Acidophilus Combined with Conventional Quadruple Therapy in the Treatment of Peptic Ulcer Caused by Helicobacter Pylori Infection[J].Journal of Medical Information,2020,33(23):138.[doi:10.3969/j.issn.1006-1959.2020.02.040]
[5]关 旭,田 桦,卓 越,等.不同疗程布拉氏酵母菌对四联疗法根除Hp的影响[J].医学信息,2020,33(05):144.[doi:10.3969/j.issn.1006-1959.2020.05.046]
　GUAN Xu,TIAN Hua,ZHUO Yue,et al.Effects of Different Courses of Candida Bratella on the Eradication of Hp by Quadruple Therapy[J].Journal of Medical Information,2020,33(23):144.[doi:10.3969/j.issn.1006-1959.2020.05.046]
[6]罗小洋,刘戈云,熊 欢,等.老年性胃溃疡相关因素临床研究[J].医学信息,2022,35(18):93.[doi:10.3969/j.issn.1006-1959.2022.18.024]
　LUO Xiao-yang,LIU Ge-yun,XIONG Huan,et al.Clinical Study on Related Factors of Senile Gastric Ulcer[J].Journal of Medical Information,2022,35(23):93.[doi:10.3969/j.issn.1006-1959.2022.18.024]
[7]郭月欢,甘惠中.幽门螺旋杆菌感染与非酒精性脂肪肝的相关性研究[J].医学信息,2022,35(08):89.[doi:10.3969/j.issn.1006-1959.2022.08.021]
　GUO Yue-huan,GAN Hui-zhong.Correlation Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease[J].Journal of Medical Information,2022,35(23):89.[doi:10.3969/j.issn.1006-1959.2022.08.021]
[8]陈淑平,张 苗,王丽芳.蒲公英联合四联方案治疗脾胃湿热型幽门螺旋杆菌感染相关性胃炎的疗效[J].医学信息,2023,36(13):107.[doi:10.3969/j.issn.1006-1959.2023.13.021]
　CHEN Shu-ping,ZHANG Miao,WANG Li-fang.Efficacy of Dandelion Combined with Quadruple Regimen in the Treatment of Helicobacter Pylori Infection-related Gastritis of Spleen-stomach Damp-heat Type[J].Journal of Medical Information,2023,36(23):107.[doi:10.3969/j.issn.1006-1959.2023.13.021]
[9]闫静静,韩 怡.幽门螺旋杆菌感染与非酒精性脂肪性肝病的相关性研究[J].医学信息,2023,36(18):114.[doi:10.3969/j.issn.1006-1959.2023.18.021]
　YAN Jing-jing,HAN Yi.Correlation Analysis Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease[J].Journal of Medical Information,2023,36(23):114.[doi:10.3969/j.issn.1006-1959.2023.18.021]
[10]刘克学.铝碳酸镁联合兰索拉唑治疗幽门螺旋杆菌相关性胃溃疡的临床疗效及安全性[J].医学信息,2023,36(18):140.[doi:10.3969/j.issn.1006-1959.2023.18.027]
　LIU Ke-xue.Clinical Efficacy and Safety of Hydrotalcite Combined with Lansoprazole in the Treatment of Helicobacter Pylori-associated Gastric Ulcer[J].Journal of Medical Information,2023,36(23):140.[doi:10.3969/j.issn.1006-1959.2023.18.027]

更新日期/Last Update: 2018-12-17