[1]杨进斌,韩建阁.右美托咪定复合丙泊酚和芬太尼在无痛人流术中的应用观察[J].医学信息,2018,31(03):134-136.[doi:10.3969/j.issn.1006-1959.2018.03.047]
 YANG Jin-bin,HAN Jian-ge.Application of Dexmetomidine Combined with Propofol and Fentanyl in Painless Induced Abortion[J].Journal of Medical Information,2018,31(03):134-136.[doi:10.3969/j.issn.1006-1959.2018.03.047]
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右美托咪定复合丙泊酚和芬太尼在无痛人流术中的应用观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年03期
页码:
134-136
栏目:
药物与临床
出版日期:
2018-02-01

文章信息/Info

Title:
Application of Dexmetomidine Combined with Propofol and Fentanyl in Painless Induced Abortion
文章编号:
1006-1959(2018)03-0134-03
作者:
杨进斌12韩建阁3
1.天津医科大学研究生院,天津 300070;2.海洋石油总医院,天津 300452;3.天津市胸科医院,天津 300051
Author(s):
YANG Jin-bin12HAN Jian-ge3
1.Graduate School of Tianjin Medical University,Tianjin 300070,China;2.Offshore Oil General Hospital,Tianjin 300452,China;3.Tianjin Chest Hospital,Tianjin 300051,China
关键词:
右美托咪定丙泊酚无痛人流术镇静并发症
Keywords:
DexmedetomidinePropofolPainless abortionSedationComplications
分类号:
R614
DOI:
10.3969/j.issn.1006-1959.2018.03.047
文献标志码:
A
摘要:
目的 观察右美托咪定复合丙泊酚和芬太尼在无痛人流术中的应用。方法 选择择期行无痛人流术的患者400例,随机分为丙泊酚和芬太尼组(P组)以及右美托咪定复合丙泊酚和芬太尼组(EP组)。术前2 min给予芬太尼0.5 μg/kg静注,术中丙泊酚以靶控(TCI)模式输注,右美托咪定以恒速模式输注,根据患者镇静深度适当调整注射速度。记录所有患者的药物起效时间、操作时间、苏醒时间以及出室时间,并记录低血压、心动过缓、缺氧和注射痛等不良事件。结果 EP组围术期低血压、心动过缓、缺氧、注射痛发生率较P组显著降低,差异具有统计学意义(P<0.01);EP组患者的起效时间较P组长,差异有统计学意义(P<0.05),而两组患者操作时间、苏醒时间、出室时间以及出室前VAS值差异无统计学意义(P>0.05)。结论 右美托咪定复合丙泊酚和芬太尼在无痛人流术中对呼吸、循环系统影响小,注射痛发生率更小,显著提高无痛人工流产术的安全性及舒适性。
Abstract:
Objective To observe the application of dexmetomidine combined with propofol and fentanyl in painless abortion.Methods 400 patients undergoing painless abortion were randomly divided into propofol and fentanyl group (P group) and Dexmedetomidine combined with propofol and fentanyl group (group EP).Preoperative 0.5μg/kgfentanyl intravenous injection2 min before the operation, intraoperative infusionof propofol in target controlled (TCI) mode, dexmedetomidine infusion at a constant speed mode, adjust the injection speed according to the depth of sedation of patients. Drug onset time, operation time, recovery time and ventricular exit time were recorded in all patients. Adverse events such as hypotension, bradycardia, anoxia and injection pain were recorded.Results The incidence of hypotension bradycardia hypoxia and injection pain in EP group was significantly lower than that in P group,the difference was statistically significant(P< 0.01). The onset time of EP group was significantly higher than that of P group,the difference was statistically significant(P< 0.05).However, there was no significant difference in operation time, recovery time, ventricular exit time and VAS value between the two groups (P> 0.05).Conclusion Dexmetomidine combined with propofol and fentanyl has little effect on respiratory and circulatory system and less incidence of injection pain during painless artificial abortion, which can significantly improve the safety and comfort of painless induced abortion.

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更新日期/Last Update: 2018-02-01