[1]阚强波,田灿琼,付玉东,等.生物标记物在肺挫伤中的应用价值[J].医学信息,2018,31(08):31-34.[doi:10.3969/j.issn.1006-1959.2018.08.011]
　KAN Qiang-bo,TIAN Can-qiong,FU Yu-dong,et al.Application Value of Biomarkers in Lung Contusion[J].Journal of Medical Information,2018,31(08):31-34.[doi:10.3969/j.issn.1006-1959.2018.08.011]
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生物标记物在肺挫伤中的应用价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年08期
页码:
31-34
栏目:
综述
出版日期:
2018-04-15

文章信息/Info

Title:
Application Value of Biomarkers in Lung Contusion
文章编号:
1006-1959（2018）08-0031-04
作者:
阚强波1; 田灿琼1; 付玉东1; 王俊峰1; 侯 波1; 洪志鹏2
1.云南省曲靖市第一人民医院胸外科，云南 曲靖 655000； 2.昆明医科大学第一附属医院胸外科，云南 昆明 650000
Author(s):
KAN Qiang-bo1; TIAN Can-qiong1; FU Yu-dong1; WANG Jun-feng1; HOU Bo1; HONG Zhi-peng2
1.Department of Thoracic Surgery,the First People's Hospital of Qujing City,Qujing 655000,Yunnan,China; 2.Department of Thoracic Surgery,First Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China
关键词:
生物标记物; 肺挫伤; 急性呼吸窘迫综合症
Keywords:
Key words：Biomarkers; Pulmonary contusion; Acute respiratory distress syndrome
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2018.08.011
文献标志码:
A
摘要:
急性炎症反应在肺挫伤的病理生理学中的重要作用已得到广泛认可，炎症反应是肺挫伤后病情演变加重的主要因素。肺挫伤与急性肺损伤和急性呼吸窘迫综合症的发生具有临床相关性已形成共识，然而免疫学评分和方法用于检测和评估肺挫伤的严重程度在临床中还没有建立，一种可能的方法是通过监测常规炎症标记物反映肺挫伤后发生的免疫反应。国外相关研究已表明炎症直接相关的生物标志物，如促血管生成素2、白介素6和降钙素原与炎症间接相关的标记物如人五聚素3和肾上腺髓质素原，它们都是ARDS的独立潜在危险因素。
Abstract:
Abstract：The important role of acute inflammatory reaction in the pathophysiology of lung contusion has been widely recognized. Inflammatory reaction is the main factor of exacerbation of the disease after lung contusion.There is a consensus that there is a clinical correlation between lung contusion and the occurrence of acute lung injury and acute respiratory distress syndrome.However, immunological scores and methods for detecting and evaluating the severity of lung contusion have not been established in clinical practice.One possible method is to monitor routine inflammatory markers to reflect the immune response after lung contusion.Foreign studies have shown that biomarkers directly related to inflammation,such as angiopoietin 2,interleukin 6 and calcitonin,are indirectly associated with inflammation,such as human pentagglutinin 3 and adrenomedullin,they are independent potential risk factors for ARDS.

参考文献/References:

[1]Artigas A,Bernard GR,Carlet J,et al.The American-European Consensus Conference on ARDS,Part 2[J].Intensive Care Med,1998,24(4):378-398.
[2]王邵华.炎症反应在肺挫伤中的作用机制研究进展[J].中国胸心血管外科临床杂志,2011,18(3):253-256.
[3]Hoth JJ,Martin RS,Yoza BK,et al.Pulmonary contusion primes systemic innate immunity responses[J].J Trauma,2009,67(1):14-21.
[4]Gallagher DC,Parikh SM,Balonov K,et al.Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury adult respiratory distress syndrome[J].Shock,2008,29(6):656-661.
[5]Persson C,Uller L.Transepithelial exit of leucocy tes:inflicting,reflecting or resolving airway inflammation[J].Thorax,2010,65(12):1111-1115.
[6]Tsantes A,Tsangaris I,Kopterides P,et al.The role of procalcitonin and IL-6 in discriminating between septic and non-septic causes of ALI/ARDS:a prospective observational study[J].Clin Chem Lab Med,2013,51(7):1535-1542.
[7]Stiletto RJ,Baacke M,Gotzen L,et al.Procalcitonin versus interleukin-6 levels in bronchoalveolar lavage fluids of trauma victims with severe lung contusion[J].Crit Care Med,2001,29(9):1690-1693.
[8]Lederer W,Stichlberger M,Hausdorfer J,et al.Alveolar neopterin,procalcitonin, and IL-6 in relation to serum levels and severity of lung injury in ARDS[J].Clin Chem Lab Med,2013,51(9):213-215.
[9]Brunkhorst FM,Eberhard OK,Brunkhorst R.Discrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitonin[J].Crit Care Med,1999,27(10):2172-2176.
[10]Assicot M,Gendrel D,Carsin H,et al.High serum procalcitonin concentrations in patients with sepsis and infection[J].Lancet,1993,341(8844):515-518.
[11]Chirouze C,Schuhmacher H,Rabaud C,et al.Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever[J].Clin Infect Dis,2002,35(2):156-161.
[12]Dandona P,Nix D,Wilson MF,et al.Procalcitonin increase after endotoxin injection in normal subjects[J].J Clin Endocrinol Metab,1994,79(6):1605-1608.
[13]Chastre J,Fagon JY.Ventilator-associated pneumonia[J].Am J Respir Crit Care Med,2002,165(7):867-903.
[14]Dupont H,Mentec H,Sollet JP,et al.Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia[J].Intensive Care Med,2001,27(2):355-362.
[15]Christ-Crain M,Jaccard-Stolz D,Bingisser R,et al.Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory z infections:cluster-randomised, singleblinded intervention trial[J].Lancet,2004,363(9409):600-607.
[16]Meisner M,Tschaikowsky K,Palmaers T,et al.Comparison of procalcitonin(PCT)and C-reactive protein(CRP)plasma concentrations at different SOFA scores during the course of sepsis and MODS[J].Crit Care,1999,3(1):45-50.
[17]Muller B,Becker KL,Schachinger H,et al.Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit[J].Crit Care Med,2000,28(4):977-983.
[18]Pettila V,Hynninen M,Takkunen O,et al.Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis[J].Intensive Care Med,2002,28(9):1220-1225.
[19]Wanner GA,Keel M,Steckholzer U,et al.Relationship between procalcitonin plasma levels and severity of injury,sepsis, organ failure,and mortality in injured patients[J].Crit Care Med,2000,28(4):950-957.
[20]Harbarth S,Holeckova K,Froidevaux C,et al.Diagnostic value of procalcitonin,interleukin-6,and interleukin-8 in critically ill patients admitted with suspected sepsis[J].Am J Respir Crit Care Med,2001,164(3):396-402.
[21]Ullman EA,Donley LP,Brady WJ,et al.Pulmonary trauma emergency department evaluation and management[J].Emerg Med Clin North Am,2003,21(2):291-313.
[22]Surdhar GK,Enayat MS,Lawson S,et al.Homozygous gene conversion in von Willebrand factor gene as a cause of type 3von Willebrand disease and predisposition to inhibitor development[J].Blood,2001,98(1):248-250.
[23]Blann AD,Taberner DA.A reliable marker of endothelial cell dysfunction:does it exist [J].Br J Haematol,1995,90(2):244-248.
[24]Siemiatkowski A,Kloczko J,Galar M,et al.von Willebrand factor antigen as a prognostic maker in posttraumatic acute lung injury[J].Haemostasis,2000,30(4):189-195.
[25]Flori HR,Ware LB,Milet M,et al.Early elevation of plasma von Willebrand factor antigen in pediatric acute lung injury is associated with an increased risk of death and prolonged mechanical ventilation[J].Pediatr Crit Care Med,2007,8(2):96-101.
[26]Van der Heijden M,van Nieuw Amerongen GP,Koolwijk P,et al.Angiopoietin-2,permeability oedema,occurrence and severity of ALI ARDS in septic and non-septic critically ill patients[J].Thorax,2008,63(10):903-909.
[27]Calfee CS,Delucchi K,Parsons PE,et al.Subphenotypes in acute respiratory distress syndrome:latent class analysis of data from two randomised controlled trials[J].Lancet Respir Med,2014,2(8):611-620.
[28]He X,Han B,Liu M.Long pentraxin 3 in pulmonary infction and acute lung injury[J].Am J Physiol Lung Cell Mol Physiol,2007,292(5):L1029-L1049.
[29]Fuchs D,Weiss G,Reibnegger G,et al.The role of neopterin as a monitor of cellular immune activation in transplantation,inflammatory,infectious,and malignant diseases[J].Crit Rev Clin Lab Sci,1992,29(3-4):307-341.
[30]Dhondt JL,Darras A,Mulliez P,et al.Unconjugated pteridines in bronchoalveolar lavage as indicators of alveolar macrophage activation[J].Chest,1989,95(2):348-351.
[31]Bühling F,Thlert G,Kaiser D,et al.Increased release of transforming growth factor(TGF)-beta1,TGF-beta2,and chemoattractant mediators in pneumonia[J].J Interferon Cytokine Res,1999,19(3):271-278.
[32]Christ-Crain M,Morgenthaler NG,Struck J,et al.Mid-regional pro-adrenomedullin as a prognostic marker in sepsis:an observational study[J].Crit Care,2005,9(6):R816-R824.
[33]Hoeboer SH,Groeneveld AB,van der Heijden M,et al.Serial inflammatory biomarkers of the severity,course and outcome of late onset acute respiratory distress syndrome in critically ill patients with or at risk for the syndrome after new-onset fever[J].Biomark Med,2015,9(6):605-616.
[34]Gallagher DC,Parikh SM,Balonov K,et al.Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury adult respiratory distress syndrome[J].Shock,2008,29(6):656-661.

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更新日期/Last Update: 2018-04-15