[1]张益勋,胡逸萍,钟穗航,等.DNA甲基化在病理性瘢痕中的作用研究[J].医学信息,2018,31(09):46-48,52.[doi:10.3969/j.issn.1006-1959.2018.09.015]
 ZHANG Yi-xun,HU Yi-ping,ZHONG Sui-hang,et al.Study on the Role of DNA Methylation in Pathological Scars[J].Journal of Medical Information,2018,31(09):46-48,52.[doi:10.3969/j.issn.1006-1959.2018.09.015]
点击复制

DNA甲基化在病理性瘢痕中的作用研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年09期
页码:
46-48,52
栏目:
综述
出版日期:
2018-05-01

文章信息/Info

Title:
Study on the Role of DNA Methylation in Pathological Scars
文章编号:
1006-1959(2018)09-0046-04
作者:
张益勋胡逸萍钟穗航谢有富
暨南大学附属广州市红十字会医院烧伤整形科,广东 广州 510220
Author(s):
ZHANG Yi-xunHU Yi-pingZHONG Sui-hangXIE You-fu
Department of Burn and Plastic Surgery,Guangzhou Red Cross Hospital,Jinan University,Guangzhou 510220,Guangdong,China
关键词:
病理性瘢痕增生性瘢痕瘢痕疙瘩DNA甲基化
Keywords:
Key words:Pathological scarsHypertrophic scarKeloidDNA methylation
分类号:
R363
DOI:
10.3969/j.issn.1006-1959.2018.09.015
文献标志码:
A
摘要:
病理性瘢痕是指烧伤、创伤和手术等后创面过度修复引起,以胶原等大量细胞外基质产生与沉积失衡为特征的皮肤纤维增生性疾病,包括增生性瘢痕与瘢痕疙瘩等。随着对增生性瘢痕研究的不断深入,人们发现DNA甲基化在瘢痕形成的发生和发展过程中起着重要的作用。本文就DNA甲基化在病理性瘢痕中作用的研究进展进行综述。
Abstract:
Abstract:Pathological scars are caused by excessive repair of wounds after burn,trauma,and surgery,which are caused by a large amount of extracellular matrix produced by collagen and other extracellular matrix,including hyperplastic scar and keloid.With the development of hypertrophic scar,DNA methylation plays an important role in the occurrence and development of scar formation.This article reviews the research progress of the role of DNA methylation in pathological scars.

参考文献/References:

[1]Safonov I.Pathological Scars(Keloid and Hypertrophic Scars)[M].Atlas of Scar Treatment and Correction.Springer Berlin Heidelberg,2012:97-160.
[2]Biao Hu,Mehrnaz Gharaee-Kermani,Zhe Wu.Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation[J].Am J Pathol,2010,177(1):21-28.
[3]Zhang X,Hu M,Lyu X,et al.DNA methylation regulated gene expression in organ fibrosis[J].Biochim Biophys Acta,2017,1863(9):2389-2397.
[4]Podolak-Popinigis J,Ronowicz A,Dmochowska M,et al.The methylome and transcriptome of fetal skin:implications for scarless healing[J].Epigenomics,2016,8(10):1331-1345.
[5]Helliwell CA,Gonzalez-Bayon R.Epigenetics[J].Encyclopedia of Applied Plant Sciences,2017(2):152-156.
[6]Hermann A,Gowher H,Jeltsch A.Biochemistry and biology of mammalian DNA methyltransferases[J].Cellular and Molecular Life Sciences,2004,61(19-20):2571-2587.
[7]Edwards JR,Yarychkivska O,Boulard M,et al.DNA methylation and DNA methyltransferases[J].Epigenetics Chromatin,2017(10):23.
[8]Bestor TH.The DNA methyltransferases of mammals[J].Human Molecular Genetics,2000,9(16):2395-2402.
[9]Robert MF,Morin S,Beaulieu N,et al.DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells[J].Nat Genet,2003,33(1):61-65.
[10]Dowson C,O'Reilly S.DNA methylation in fibrosis[J].Eur J Cell Biol,2016,95(9):323-330.
[11]Hao X,Luo H,Krawczyk M,et al.DNA methylation markers for diagnosis and prognosis of common cancers[J].Proc Natl Acad Sci USA,2017,114(28):7414-7419.
[12]Lewis CJ,Mardaryev AN,Sharov AA,et al.The Epigenetic Regulation of Wound Healing[J].Adv Wound Care,2014,3(7):468-475.
[13]Saldanha SN,Royston KJ,Udayakumar N,et al.Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing[J].Int J Mol Sci,2015,17(1):E16.
[14]Zhang S,Duan E.Epigenetic regulations on skin wound healing: implications from current researches[J].Ann Transl Med,2015,3(16):227.
[15]Fu S,Sun L,Zhang X,et al.5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor[J].Exp Eye Res,2017(165):47-58.
[16]Darby IA,Zakuan N,Billet F,et al.The myofibroblast,a key cell in normal and pathological tissue repair[J].Cellular and Molecular Life Sciences,2016,73(6):1145-1157.
[17]Gabbiani G,Majno G.Dupuytren's contracture:fibroblast contraction An ultrastructural study[J].American Journal of Pathology,1972,66(1):131-146.
[18]Bechtel W,McGoohan S,Zeisberg EM,et al.Methylation determines fibroblast activation and fibrogenesis in the kidney[J].Nature Medicine,2010,16(5):544-550.
[19]杨娥,张恒术.烧伤创面愈合后瘢痕组织成纤维细胞DNA甲基化初步研究[J].中国烧伤创疡杂志,2015,27(03):219-223.
[20]Cisneros J,Hagood J,Checa M,et al.Hypermethylation-mediated silencing of p14(ARF)in fibroblasts from idiopathic pulmonary fibrosis[J].American Journal of Physiology,2012,303(4):L295-L303.
[21]Kotake Y,Naemura M,Murasaki C,et al.Transcriptional Regulation of the p16 Tumor Suppressor Gene[J].Anticancer Research,2015,35(8):4397-4401.
[22]姚庆君,陈璧,胡大海,等.深Ⅱ度烧伤早期及愈后增生性瘢痕组织中p16基因表达的甲基化调控[J].第四军医大学学报,2005,26(04):371-373.
[23]Chalmers RL.The evidence for the role of transforming growth factor-beta in the formation of abnormal scarring[J].International Wound Journal,2011,8(3):218-223.
[24]Xie JL,Qi SH,Pan S,et al.Expression of Smad Protein by Normal Skin Fibroblasts and Hypertrophic Scar Fibroblasts in Response to Transforming Growth Factor β1[J].Dermatologic Surgery,2008,34(9):1216-1224.
[25]Xu M,He J,Li J,et al.Methyl-CpG-binding domain 3 inhibits epithelial-mesenchymal transition in pancreatic cancer cells via TGF-β Smad signalling[J].British Journal of Cancer,2017,116(1):91-99.
[26]E Y,Qipa Z,Hengshu Z.The Expression of DNMT1 in Pathologic Scar Fibroblasts and the Effect of 5-aza-2-Deoxycytidine on Cytokines of Pathologic Scar Fibroblasts[J].Wounds,2014,26(5):139-146.
[27]He Y,Deng Z,Alghamdi M,et al.From genetics to epigenetics:new insights into keloid scarring[J].Cell Prolif,2017,50(2).
[28]季江,冷红,冀胜军,等.瘢痕疙瘩及其成纤维细胞p16基因甲基化状态和相关基因表达研究[J].中华皮肤科杂志,2015,48(3):171-174.
[29]Zou QP,Yang E,Zhang HS.Effect of the methylation enzyme inhibitors of 5-aza-2-deoxycytidine on the TGF-beta smad signal transduction pathway in human keloid fibroblasts[J].Chinese Journal Of Plastic Surgery,2013,29(4):285-289.
[30]Rooney N,Riggio AI,Mendoza-Villanueva D,et al.Runx Genes in Breast Cancer and the Mammary Lineage[J].Adv Exp Med Biol,2017(962):353-368.
[31]RUNX Genes in Development and Cancer: Regulation of Viral Gene Expression and the Discovery of RUNX Family Genes[J].Advances in Cancer Research,2008(99):33-76.
[32]陈贵宗.甲基化抑制剂对瘢痕疙瘩成纤维细胞RUNX3及Cdc2L1基因转录调节作用研究[D].广东医学院,2012.
[33]Feng Y,Goulet AC,Nelson MA.Identification and characterization of the human Cdc2l2 gene promoter[J].GENE,2004(330):75-84.
[34]Zhang G,Jiang J,Luo S,et al.Analyses of CDC2L1 gene mutations in keloid tissue[J].Clinical and Experimental Dermatology,2012,37(3):277-283.
[35]Zhang G,Guan Q,Chen G,et al.DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts[J].Arch Dermatol Res,2017.
[36]Garcia-Rodriguez L,Jones L,Chen KM,et al.Causal network analysis of head and neck keloid tissue identifies potential master regulators[J].Laryngoscope,2016,126(10):E319-E324.
[37]苑春雨.瘢痕疙瘩中lncRNA表达谱及基因组甲基化异常的初探[D].北京协和医学院,2017.

相似文献/References:

[1]杜雅静,王宇意,章丹婷,等.研磨珠均质仪提取增生性瘢痕组织蛋白质的方法[J].医学信息,2018,31(15):51.[doi:10.3969/j.issn.1006-1959.2018.15.017]
 DU Ya-jing,WANG Yu-yi,ZHANG Dan-ting,et al.Method for Extracting Hyperplastic Scar Tissue Protein by Grinding Bead Homogenizer[J].Journal of Medical Information,2018,31(09):51.[doi:10.3969/j.issn.1006-1959.2018.15.017]
[2]朱伟东,王富生,王志远.瘢痕组织中胶原蛋白提取及纯化研究[J].医学信息,2018,31(17):84.[doi:10.3969/j.issn.1006-1959.2018.17.025]
 ZHU Wei-dong,WANG Fu-sheng,WANG Zhi-yuan.Extraction and Purification of Collagen from Scar Tissue[J].Journal of Medical Information,2018,31(09):84.[doi:10.3969/j.issn.1006-1959.2018.17.025]
[3]韩玉丽,刘琪琪,李 真,等.增生性瘢痕分子信号通路研究[J].医学信息,2019,32(22):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
 HAN Yu-li,LIU Qi-qi,LI Zhen,et al.Study on Molecular Signaling Pathway of Hypertrophic Scar[J].Journal of Medical Information,2019,32(09):31.[doi:10.3969/j.issn.1006-1959.2019.22.011]
[4]刘琪琪,韩玉丽,辛 燕.病理性瘢痕相关炎性因素的研究[J].医学信息,2021,34(01):41.[doi:10.3969/j.issn.1006-1959.2021.01.012]
 LIU Qi-qi,HAN Yu-li,XIN Yan.Study on Inflammatory Factors Related to Pathological Scars[J].Journal of Medical Information,2021,34(09):41.[doi:10.3969/j.issn.1006-1959.2021.01.012]
[5]蔡润智,谢有富,何飘飘,等.HIF-1α在病理性瘢痕中的作用研究[J].医学信息,2021,34(04):57.[doi:10.3969/j.issn.1006-1959.2021.04.015]
 CAI Run-zhi,XIE You-fu,HE Piao-piao,et al.Study on the Role of HIF-1α in Pathological Scars[J].Journal of Medical Information,2021,34(09):57.[doi:10.3969/j.issn.1006-1959.2021.04.015]

更新日期/Last Update: 2018-05-01