[1]褚福行,李珊珊,李思琪,等.慢性牙周炎伴肥胖患者血清中IL-6、IL-18表达水平的研究[J].医学信息,2019,32(01):92-94.[doi:10.3969/j.issn.1006-1959.2019.01.028]
　CHU Fu-xing,LI Shan-shan,LI Si-qi,et al.Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with Chronic Periodontitis and Obesity[J].Journal of Medical Information,2019,32(01):92-94.[doi:10.3969/j.issn.1006-1959.2019.01.028]
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慢性牙周炎伴肥胖患者血清中IL-6、IL-18表达水平的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年01期
页码:
92-94
栏目:
论著
出版日期:
2019-01-01

文章信息/Info

Title:
Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with Chronic Periodontitis and Obesity
文章编号:
1006-1959（2019）01-0092-04
作者:
褚福行; 李珊珊; 李思琪; 李维善
佳木斯大学附属口腔医院牙周黏膜科，黑龙江 佳木斯 154004
Author(s):
CHU Fu-xing; LI Shan-shan; LI Si-qi; LI Wei-shan
Periodontal Oral Mucosa of Stomatological Hospital Affiliated Jiamusi University,Jiamusi154004,Heilongjiang,China
关键词:
慢性牙周炎; 肥胖; IL-6; IL-18
Keywords:
Chronic periodontitis; Obesity; IL-6; IL-18
分类号:
R781.4+2
DOI:
10.3969/j.issn.1006-1959.2019.01.028
文献标志码:
A
摘要:
目的 探究白细胞介素6（IL-6）、白细胞介素18（IL-18）在肥胖慢性牙周炎患者血清中的表达水平变化及意义。方法 选取2017年9月~2018年5月在佳木斯大学附属口腔医院牙周科门诊确诊为慢性牙周炎患者15例设为NP组，另选取同期慢性牙周炎伴肥胖患者15例设为FP组。收集两组患者外周血样本并记录牙周PD、CAL，采用双抗体夹心酶联免疫吸附法（ELISA法)测定样本中的IL-6、IL-18的表达水平，分析两组间指标的差异及相关性。结果 FP组血清中IL-6、IL-18分别为（9.16±2.35）pg/ml、（325.22±98.67）pg/ml，其表达水平分别高于NP组的（6.15±2.06）pg/ml和（241.52±78.82）pg/ml，差异有统计学意义（P＜0.05）；FP组中PD与血清中IL-6、IL-18呈高度正相关（r＝0.894，P＜0.01；r＝0.819，P＜0.01）；CAL与血清中IL-6、IL-18呈正相关（r＝0.885，P＜0.01，r＝0.828，P＜0.01）；NP组中PD与血清中IL-6、IL-18也有正相关关系（r＝0.842，P＜0.01，r＝0.728，P＜0.01）；CAL与血清中IL-6、IL-18呈正相关（r＝0.884，P＜0.01，r＝0.707，P＜0.01）。结论 肥胖状态所导致的外周血中IL-6、IL-18水平的升高与CP的发生发展存在着密切联系。
Abstract:
Objective To investigate the changes and significance of interleukin-6 (IL-6) and interleukin-18 (IL-18) expression in serum of obese chronic periodontitis patients. Methods From September 2017 to May 2018, 15 patients with chronic periodontitis diagnosed in the periodontal clinic of Jiamusi University Hospital of Stomatology were selected as NP group, and 15 patients with chronic periodontitis and obesity were selected as FPgroup. Peripheral blood samples were collected from both groups and PD and CAL were recorded. The expression levels of IL-6 and IL-18 in the samples were determined by double antibody sandwich enzyme-linked immunosorbent assay (ELISA).The differences and correlations between the two groups were analyzed. Results The serum levels of IL-6 and IL-18 in FP group were (9.16±2.35) pg/ml and (325.22±98.67) pg/ml, respectively, and their expression levels were higher than that of NP group (6.15±2.06) pg/ml and (241.52±78.82) pg/ml, the difference was statistically significant (P<0.05); PD in the FP group was highly positively correlated with serum IL-6 and IL-18 (r=0.894, P<0.01;r=0.819,P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.885, P<0.01, r=0.828, P<0.01);There was a positive correlation between PD and serum IL-6 and IL-18 in NP group (r=0.842,P<0.01,r=0.728, P<0.01); CAL was positively correlated with serum IL-6 and IL-18 (r=0.884,P<0.01,r=0.707,P<0.01). Conclusion The increase of IL-6 and IL-18 levels in peripheral blood caused by obesity is closely related to the occurrence and development of CP.

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更新日期/Last Update: 2019-01-22