[1]李在明,魏正强.外泌体在结直肠癌中的研究进展[J].医学信息,2019,32(03):42-44.[doi:10.3969/j.issn.1006-1959.2019.03.014]
 LI Zai-ming,WEI Zheng-qiang.Research Progress of Exosomes in Colorectal Cancer[J].Journal of Medical Information,2019,32(03):42-44.[doi:10.3969/j.issn.1006-1959.2019.03.014]
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外泌体在结直肠癌中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年03期
页码:
42-44
栏目:
综述
出版日期:
2019-02-01

文章信息/Info

Title:
Research Progress of Exosomes in Colorectal Cancer
文章编号:
1006-1959(2019)03-0042-03
作者:
李在明魏正强
(重庆医科大学附属第一医院胃肠外科,重庆 400000)
Author(s):
LI Zai-mingWEI Zheng-qiang
(Department of Gastroenterology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400000,China)
关键词:
结直肠癌外泌体标志物肿瘤微环境
Keywords:
Colorectal cancerExosomesMarkersTumor microenvironment
分类号:
R735.35
DOI:
10.3969/j.issn.1006-1959.2019.03.014
文献标志码:
A
摘要:
近年来,由于对外泌体的不断认识和了解,研究外泌体已成为当下的热点,外泌体是细胞分泌的一种纳米级囊泡结构,可来源于机体正常细胞及肿瘤细胞,在血液、唾液、尿液、母乳等多种体液中均有分布,其参与许多生物学和病理学过程,主要是由于它们在细胞间通讯作用,源自结直肠癌(CRC)细胞的外泌体与肿瘤发生、进展、转移、预后等相关。本文就外泌体在结直肠癌中的研究进展进行综述。
Abstract:
In recent years, due to the continuous understanding and understanding of exosomes, research on exosomes has become a hot spot. Exosomes are a kind of nano-sized vesicle structure secreted by cells, which can be derived from normal cells and tumor cells in the blood. It is distributed in various body fluids such as saliva, urine, and breast milk. It is involved in many biological and pathological processes, mainly due to their intercellular communication, and the exosomes derived from colorectal cancer (CRC) cells. Tumor development, progression, metastasis, prognosis, etc. This article reviews the research progress of exosomes in colorectal cancer.

参考文献/References:


[1]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
[2]Arnold M,Mónica S Sierra,Laversanne M,et al.Global patterns and trends in colorectal cancer incidence and mortality[J].Gut,2017,66(4):683-691.
[3]Ogorevc E.The role of extracellular vesicles in phenotypic cancer transformation[J].Radiology & Oncology,2013,47(3):197-205.
[4]Jiang XC,Gao JQ.Exosomes as Novel Bio-carriers for Gene and Drug Delivery[J].International Journal of Pharmaceutics,2017,521(1-2):167-175.
[5]Hannafon B,Ding WQ.Intercellular Communication by Exosome-Derived microRNAs in Cancer[J].International Journal of Molecular Sciences,2013,14(7):14240-14269.
[6]Demory BM,Higginbotham JN,Franklin JL,et al.Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS[J].Molecular & Cellular Proteomics,2013,12(2):343-355.
[7]Chiba M,Kimura M,Asari S.Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines[J].Oncology Reports,2012,28(5):1551-1558.
[8]Simpson RJ,Lim JW,Moritz RL,et al.Exosomes: proteomic insights and diagnostic potential[J].Expert Review of Proteomics,2009,6(3):267-283.
[9]Choi DS,Park JO,Jang SC,et al.Erratum: Proteomic analysis of microvesicles derived from human colorectal cancer ascites[J].Proteomics,2011,11(13):2745-2751.
[10]Gho YS,Lee C.Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks[J].Molecular Biosystems,2017,13(7):1291.
[11]Minciacchi VR,Freeman MR,Di Vizio D.Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes[J].Seminars in Cell & Developmental Biology,2015,40(2):41-51.
[12]Bhome R,Bullock MD,Saihati HAA,et al.A top-down view of the tumor microenvironment: structure, cells and signaling[J].Frontiers in Cell & Developmental Biology,2015(3):33.
[13]Lugini L,Valtieri M,Federici C,et al.Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells[J].Oncotarget,2016,7(31):50086-50098.
[14]Dai G,Yao X,Zhang Y,et al.Colorectal cancer cell-derived exosomes containing miR-10b regulate fibroblast cells via the PI3K/Akt pathway[J].Bull Cancer,2018,105(4):336-349.
[15]Bhome R,Goh RW,Bullock MD,et al.Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression[J].Aging,2017,9(12):2666-2694.
[16]Iorio MV,Croce CM.MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review[J].EMBO Molecular Medicine,2012,4(3):143-159.
[17]Herrera M,Llorens C,Marta Rodríguez,et al.Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer[J].Molecular Cancer,2018,17(1):114.
[18]崔琮,徐建明,王友亮.外泌体在消化系统肿瘤诊断中的应用[J].世界华人消化杂志,2016(35):4644-4651.
[19]Boelens MC,Wu TJ,Nabet BY,et al.Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways[J].Cell,2014,159(3):499-513.
[20]Kurywchak P,Kalluri R.An evolving function of DNA-containing exosomes in chemotherapy-induced immune response[J].Cell Research,2017,27(6):722-723.
[21]Ren J,Ding L,Zhang D,et al.Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19[J].Theranostics,2018,8(14):3932-3948.
[22]Li C,Li W,Zhang Y,et al.Increased expression of antisense lncRNA SPINT1-AS1 predicts a poor prognosis in colorectal cancer and is negatively correlated with its sense transcript[J].Oncotargets & Therapy,2018(11):3969-3978.
[23]Liu L,Meng T,Yang XH,et al.Prognostic and predictive value of long non-coding RNA GAS5 and mircoRNA-221 in colorectal cancer and their effects on colorectal cancer cell proliferation, migration and invasion[J].Cancer Biomarkers,2018,22(2):283-299.

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更新日期/Last Update: 2019-02-25