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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:

32卷

期数:

2019年04期

页码:

145-147

栏目:

药物与临床

出版日期:

2019-02-15

文章信息/Info

Title:

Therapeutic Effect of Desloratadine Combined with Azelastine Hydrochloride Nasal Spray on Allergic Rhinitis

文章编号:

1006-1959（2019）04-0145-03

作者:

魏 巍

（佳木斯市中医院耳鼻喉科，黑龙江 佳木斯 154002）

Author(s):

WEI Wei

(Department of Otolaryngology,Jiamusi Hospital of Traditional Chinese Medicine,Jiamusi 154002,Heilongjiang,China)

关键词:

地氯雷他定; 盐酸氮卓斯汀鼻喷剂; 过敏性鼻炎; 抗过敏

Keywords:

Desloratadine; Azelastine hydrochloride nasal spray; Allergic rhinitis; Anti-allergy

分类号:

R765.21

DOI:

10.3969/j.issn.1006-1959.2019.04.047

文献标志码:

A

摘要:

目的 观察地氯雷他定联合盐酸氮卓斯汀鼻喷剂治疗过敏性鼻炎患者的临床效果。方法 选取2017年4月~2018年4月来我院就诊的过敏性鼻炎患者114例。采用随机数字表法划分法分为观察组与对照组，每组57例。对照组给予盐酸卓斯汀鼻喷剂，观察组在对照组治疗的基础上口服地氯雷他定，两组均连续治疗1个月，比较两组疗效、临床症状缓解时间、不良反应情况及指标的检测结果，随访3、6个月的复发率。结果 治疗后观察组总有效率为96.50%，高于对照组的82.46%，统计学意义显著（P＜0.01）。观察组的临床症状评分喷嚏（0.46±0.13）分、流涕（1.03±0.16）分、鼻痒（0.65±0.21）分、鼻堵（0.65±0.23）分均低于对照组的（0.87±0.21）分、（2.45±0.39）分、（2.41±0.52）分、（2.03±0.42）分，差异有统计学意义（P＜0.05）；观察组治疗后血清IgE、IL-4、Th1/Th2、IFN-γ的改善程度均优于对照组，统计学意义显著（P＜0.01）；观察组3月末复发6例（10.53%）、6月末复发14例（24.56%）均低于对照组的19例（33.33%）、27例（47.37%），统计学意义显著（P＜0.01）；两组不良反应比较，差异无统计学意义（P＞0.05）。结论 地氯雷他定与盐酸氮卓斯汀鼻喷剂治疗过敏性鼻炎，其联合使用的疗效更显著，作用时间长，不良反应少且复发率低。

Abstract:

Objective To observe the clinical effect of desloratadine combined with azelastine hydrochloride nasal spray in the treatment of patients with allergic rhinitis. Methods A total of 114 patients with allergic rhinitis who came to our hospital from April 2017 to April 2018 were selected. The random number table method was divided into observation group and control group, with 57 cases in each group. The control group was given Zhuo Sting Hydrochloride Nasal Spray, and the observation group was given oral loratadine on the basis of the control group. Both groups were treated continuously for 1 month. The efficacy of the two groups, the time of clinical symptom relief, the adverse reaction status and the results of the indicators were compared, and the recurrence rate was followed up for 3 and 6 months. Results The total effective rate of the observation group after treatment was 96.50%, which was higher than that of the control group 82.46%, statistically significant (P<0.01). The clinical symptom scores of the observation group were lower than that of the control group (0.46±0.13), salivation (1.03±0.16), nasal itching (0.65±0.21), and nasal blockage (0.65±0.23),they were lower than the control group (0.87±0.21), (2.45±0.39), (2.41±0.52), and (2.03±0.42), the difference was statistically significant (P<0.05). The improvement of IgE, IL-4, Th1/Th2 and IFN-γ was better than that of the control group, with statistical significance (P<0.01). In the observation group, 6 cases (10.53%) recurred at the end of March and 14 cases recurred at the end of June (24.56%) were lower than the control group in 19 cases (33.33%) and 27 cases (47.37%), statistically significant (P<0.01); there was no significant difference between the two groups (P>0.05). Conclusion Desloratadine and azelastine hydrochloride nasal spray are effective in the treatment of allergic rhinitis. The combined effect is more significant, with longer duration of action, less adverse reactions and lower recurrence rate.

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更新日期/Last Update: 2019-03-07