[1]吴丕六,汤 磊.PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的价值研究[J].医学信息,2019,32(04):163-165.[doi:10.3969/j.issn.1006-1959.2019.04.054]
　WU Pi-liu,TANG Lei.PCT, IL-6 and CRP Levels Predict the Value of Chorioamnionitis and Early Onset Sepsis in Patients with Premature Rupture of Fetal Membranes[J].Journal of Medical Information,2019,32(04):163-165.[doi:10.3969/j.issn.1006-1959.2019.04.054]
点击复制

PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的价值研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年04期
页码:
163-165
栏目:
诊疗技术
出版日期:
2019-02-15

文章信息/Info

Title:
PCT, IL-6 and CRP Levels Predict the Value of Chorioamnionitis and Early Onset Sepsis in Patients with Premature Rupture of Fetal Membranes
文章编号:
1006-1959（2019）04-0163-03
作者:
吴丕六1; 汤 磊2
（1.重庆市璧山区妇幼保健院新生儿科，重庆 402760；2.重庆市巴南区人民医院，重庆 401320）
Author(s):
WU Pi-liu1; TANG Lei2
(1.Department of Neonatrics,Bishan District Maternal and Child Health Hospital,Chongqing 402760,China;2.Banan People's Hospital of Chongqing,Chongqing 401320,China)
关键词:
PCT; IL-6; CRP; 胎膜早破; 绒毛膜羊膜炎; 新生儿早发性败血症
Keywords:
PCT; IL-6; CRP; Premature rupture of fetal membranes; Chorioamnionitis; Neonatal early sepsis
分类号:
R714.433
DOI:
10.3969/j.issn.1006-1959.2019.04.054
文献标志码:
A
摘要:
目的 观察联合检测PCT、IL-6和CRP水平预测未足月胎膜早破患者并发绒毛膜羊膜炎及新生儿早发性败血症的临床价值。方法 将2017年1月~2018年6月在我院治疗的70例未足月胎膜早破（PPROM）患者设为观察组，选取同期在我院产检孕周正常的70例孕妇设为对照组，根据病理检查将观察组分为绒毛膜羊膜炎组与无绒毛膜羊膜炎组，同时依据新生儿感染情况分为败血症组和非感染组。对比观察组和对照组外周血、脐血PCT、IL-6、CRP水平表达情况，并对观察组孕妇分娩后胎盘胎膜进行病理学检查以及追踪新生儿感染情况。结果 观察组孕妇外周血中PCT、IL-6、CRP水平均高于对照组，差异有统计学意义（P＜0.05）；无绒毛膜羊膜炎组PCT、IL-6、CRP水平低于绒毛膜羊膜炎组，差异有统计学意义（P＜0.05）；联合检测PCT、IL-6及CRP诊断绒毛膜羊膜炎的敏感性为68.75%、特异性为93.75%、阳性预测值为97.05%；脐血PCT、IL－6、CRP水平在败血症组新生儿中显著升高，与非感染组新生儿及对照组新生儿比较，差异有统计学意义（P＜0.05）。结论 PPROM孕妇外周血PCT、IL-6、CRP水平较高，三项指标联合检测对绒毛膜羊膜炎预测价值高，脐血PCT、IL－6、CRP水平检测有利于早期诊断新生儿早发性败血症。
Abstract:
Objective To observe the clinical value of combined detection of PCT, IL-6 and CRP levels in predicting chorioamnionitis and early onset sepsis in patients with premature rupture of fetal membranes. Methods 70 patients with premature rupture of fetal membranes (PPROM) who were treated in our hospital from January 2017 to June 2018 were enrolled in the observation group. 70 pregnant women who were normal in the gestational week of our hospital were selected as control group,according to pathological examination, the observation group was divided into chorioamnionitis group and non-chorioamnionitis group.At the same time, according to the neonatal infection, it was divided into sepsis group and non-infected group. The expressions of PCT, IL-6 and CRP in peripheral blood and cord blood were compared between the observation group and the control group. The pathological examination of the placenta membrane of the pregnant women in the observation group and the neonatal infection were followed. Results The levels of PCT, IL-6 and CRP in the peripheral blood of the pregnant women in the observation group were higher than those in the control group,the difference was statistically significant (P<0.05).The level of PCT,IL-6,CRP in non-chorioamnionitis group was significantly lower than that in chorioamnionitis group,the difference was statistically significant (P<0.05); the sensitivity of combined detection of PCT, IL-6 and CRP in the diagnosis of chorioamnionitis was 68.75%, specificity was 93.75%, positive predictive value was 97.05%; cord blood PCT, IL -6. The level of CRP was significantly increased in neonates in the septic group. Compared with the neonates in the non-infected group and the control group, the difference was statistically significant (P<0.05). Conclusion The peripheral blood of PPROM is higher in PCT, IL-6 and CRP. The combined detection of three indicators has high predictive value for chorioamnionitis. The detection of cord blood PCT, IL-6 and CRP levels is helpful for early diagnosis of early onset sepsis in neonates.

参考文献/References:


[1]Cabrera IB,Qui?觡ones JN,Durie D,et al.Use of intracervical balloons and chorioamnionitis in term premature rupture of membranes[J].J Matern Fetal Neonatal Med,2016,29(6):967-971.
[2]中华医学会妇产科学分会产科学组.胎膜早破的诊断与处理指南(2015)[J].中华妇产科杂志,2015,50(1):3-8.
[3]李婷婷,黄为民.未足月胎膜早破时间与组织学绒毛膜羊膜炎的相关性[J].实用医学杂志,2016,32(11):1831-1833.
[4]宋继荣,单海欧.胎膜早破孕妇IL-8及TNF-α的含量与绒毛膜羊膜炎及新生儿预后的关系[J].黑龙江医药科学,2015,38(6):146-147.
[5]Wortham JM,Hansen NI,Schrag SJ,et al.Chorioamnionitis and culture-confirmed，early-onset neonatal infections[J].Pediatrics,2016,137(1):1-11.
[6]邓秀容.降钙素原测定在未足月胎膜早破孕妇中的应用[J].实用中西医结合临床,2016,16(5):67-68．
[7]Lee J,Romero R,Kim SM,et al.A new anti-microbial combination prolongs the latency period,reduces acute histologic chorioamnionitis as well as funisitis，and improves neonatal outcomes in pretermPROM[J].J Matern Fetal Neonatal Med,2016,29(5):707-720.
[8]李小林,李静.早产胎膜早破合并绒毛膜羊膜炎的预测研究进展[J].中国综合临床,2015,31(7):667-669.

相似文献/References:

[1]张 洁.WBC、CRP和PCT在急诊发热患者诊治中的应用[J].医学信息,2018,31(07):157.[doi:10.3969/j.issn.1006-1959.2018.07.055]
　ZHANG Jie.Application of WBC,CRP and PCT in Diagnosis and Treatment of Emergency Fever Patients[J].Journal of Medical Information,2018,31(04):157.[doi:10.3969/j.issn.1006-1959.2018.07.055]
[2]金力荣,杨麦青,徐洪波,等.TGF-β1、TNF-α、IL-4、IL-6在早期胚胎停育中的意义[J].医学信息,2022,35(11):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
　JIN Li-rong,YANG Mai-qing,XU Hong-bo,et al.Significance of TGF-β1, TNF-α, IL-4 and IL-6 in Early Embryo Arrest[J].Journal of Medical Information,2022,35(04):93.[doi:10.3969/j.issn.1006-1959.2022.11.024]
[3]管 建,姜娟娟.血清IL-6、IL-10、CRP和PCT水平检测对手足口病早期 合并细菌感染患儿的临床诊断价值[J].医学信息,2018,31(15):146.[doi:10.3969/j.issn.1006-1959.2018.15.047]
　GUAN Jian,JIANG Juan-juan.Clinical Diagnostic Value of Serum Levels of IL-6,IL-10,CRP and PCT in Children with Hand-Foot-and-Mouth Disease Combined with Early Bacterial Infection[J].Journal of Medical Information,2018,31(04):146.[doi:10.3969/j.issn.1006-1959.2018.15.047]
[4]甘维桃,曾 凡,冮绍斌.乌司他丁对膝关节置换术后关节炎症及周围肿胀的影响[J].医学信息,2019,32(02):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
　GAN Wei-tao,ZENG Fan,GANG Shao-bin.Effect of Ulinastatin on Joint Inflammation and Peripheral Swelling after Knee Joint Replacement[J].Journal of Medical Information,2019,32(04):161.[doi:10.3969/j.issn.1006-1959.2019.02.049]
[5]陈恒安,胡 海,刘金龙,等.股骨头坏死骨髓IL-6表达与骨髓水肿分级的相关性研究[J].医学信息,2019,32(03):65.[doi:10.3969/j.issn.1006-1959.2019.03.021]
　CHEN Heng-an,HU Hai,LIU Jin-long,et al.Correlation between Bone Marrow IL-6 Expression and Grade of Bone Marrow Edema in Osteonecrosis of Femoral Head[J].Journal of Medical Information,2019,32(04):65.[doi:10.3969/j.issn.1006-1959.2019.03.021]
[6]褚福行,李珊珊,李思琪,等.慢性牙周炎伴肥胖患者血清中IL-6、IL-18表达水平的研究[J].医学信息,2019,32(01):92.[doi:10.3969/j.issn.1006-1959.2019.01.028]
　CHU Fu-xing,LI Shan-shan,LI Si-qi,et al.Study on the Expression Levels of IL-6 and IL-18 in Serum of Patients with Chronic Periodontitis and Obesity[J].Journal of Medical Information,2019,32(04):92.[doi:10.3969/j.issn.1006-1959.2019.01.028]
[7]卢 俊,邓佳秀,秦 娟,等.血浆中TNF-α、IL-6、ACE水平及DVH参数与放射性肺炎发生的相关性分析[J].医学信息,2019,32(10):78.[doi:10.3969/j.issn.1006-1959.2019.10.026]
　LU Jun,DENG Jia-xiu,QIN Juan,et al.Correlation between TNF-α,IL-6,ACE Levels and DVH Parameters in Plasma and the Occurrence of Radiation Pneumonitis[J].Journal of Medical Information,2019,32(04):78.[doi:10.3969/j.issn.1006-1959.2019.10.026]
[8]易晓明,曾 芬.甲泼尼龙治疗SCAP的效果及其对降钙素原水平的影响[J].医学信息,2019,32(21):145.[doi:10.3969/j.issn.1006-1959.2019.21.047]
　YI Xiao-ming,ZENG Fen.Effect of Methylprednisolone on SCAP and its Effect on Procalcitonin Level[J].Journal of Medical Information,2019,32(04):145.[doi:10.3969/j.issn.1006-1959.2019.21.047]
[9]周雯雯.支原体肺炎与细菌性肺炎炎性指标及血清降钙素原水平比较[J].医学信息,2020,33(02):169.[doi:10.3969/j.issn.1006-1959.2020.02.054]
　ZHOU Wen-wen.Comparison of Inflammatory Indexes and Serum Procalcitonin Levels in Mycoplasma Pneumonia and Bacterial Pneumonia[J].Journal of Medical Information,2020,33(04):169.[doi:10.3969/j.issn.1006-1959.2020.02.054]
[10]陈少忠.IL-6、TNF-α及血磷在老年脓毒症患者中的变化和相关性[J].医学信息,2020,33(05):119.[doi:10.3969/j.issn.1006-1959.2020.05.038]
　CHEN Shao-zhong.Changes and Correlations of IL-6,TNF-α and Blood Phosphorus in Elderly Patients with Sepsis[J].Journal of Medical Information,2020,33(04):119.[doi:10.3969/j.issn.1006-1959.2020.05.038]

更新日期/Last Update: 2019-03-07