[1]李 俊,李春英.CD44v4在乳腺浸润性导管癌中的表达及 其与浸润转移的关系[J].医学信息,2019,32(11):95-97.[doi:10.3969/j.issn.1006-1959.2019.11.025]
　LI Jun,LI Chun-ying.Expression of CD44v4 in Breast Invasive Ductal Carcinoma and Its Relationship with Invasion and Metastasis[J].Journal of Medical Information,2019,32(11):95-97.[doi:10.3969/j.issn.1006-1959.2019.11.025]
点击复制

CD44v4在乳腺浸润性导管癌中的表达及 其与浸润转移的关系()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年11期
页码:
95-97
栏目:
论著
出版日期:
2019-06-01

文章信息/Info

Title:
Expression of CD44v4 in Breast Invasive Ductal Carcinoma and Its Relationship with Invasion and Metastasis
文章编号:
1006-1959（2019）11-0095-03
作者:
李 俊1; 李春英2
柳州市柳铁中心医院普外科1，病理科2，广西 柳州 545007
Author(s):
LI Jun1; LI Chun-ying2
Department of General Surgery1,Department of Pathology2,Liuzhou Municiple Liutie Central Hospital, Liuzhou 545007,Guangxi,China
关键词:
浸润性乳腺癌; CD44v4; 浸润转移
Keywords:
Key words：Breast invasive ductal carcinoma; CD44v4; Invasion and metastasis
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2019.11.025
文献标志码:
A
摘要:
目的 探讨CD44v4在浸润性乳腺导管癌中的表达及其与浸润转移的关系。方法 选取2011年1月~2018年3月我院收治的乳腺浸润性导管癌185例设为观察组，另选取同期收治的乳腺良性疾病患者60例设为对照组，采用免疫组化法检测两组CD44v4的表达情况，并比较观察组CD44v4表达及临床病理因素情况。结果 观察组CD44v4阳性表达率为60.54%，高于对照组的5.00%，差异有统计学意义（P＜0.05）。CD44v4表达在不同年龄、绝经前后月经状况、原发瘤大小间比较，差异无统计学意义（P＞0.05）；不同TNM分期、组织学分级、淋巴结转移患者的CD44v4表达比较，差异有统计学意义（P＜0.05）。结论 CD44v4蛋白在乳腺浸润性导管癌患者中为高表达，检测其表达可作为判断肿瘤预后的新指标。
Abstract:
Abstract：Objective To investigate the expression of CD44v4 in breast invasive ductal carcinoma and its relationship with invasion and metastasis.Methods A total of 185 patients breast invasive ductal carcinoma as observation group, and 60 patients with benign breast diseasea as control group, were admitted to our hospital from January 2011 to March 2018. The immunohistochemical method was used to detect the expression of CD44v4 between two groups, and the correlation between the CD44v4 expression and clinicopathologic factors of observation group was analyzed.Results The positive rate of CD44v4 expression was 60.54%,which was higher than that 5.00% of control group, the difference was statistically significant (P＜0.05). There was no statistically significant among different age, pre- and postmenopausal, different size of primary tumors with CD44v4 expression in observation group(P＞0.05); there was statistically significant between CD44v4 expression and patients in different TNM stage, histological grade and lymph node metastasis(P＜0.05).Conclusion CD44v4 is highly expressed in breast invasive ductal carcinoma patients, and it can be used as a new marker to judge the prognosis of breast cancer.

参考文献/References:

[1]Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China[J].Lancet Oncol,2014,15(7):279-289. [2]Chas M,Boivin L,Arbion F,et al．Clinicopathologic predictors of lymph node metastasis in breast cancer patients according to molecular subtype[J].J Gynecol Obstet Hum Reprod,2018,47(1):9-15. [3]Wang HK,Liang JF,Zheng HX,et al.Expression and prognostic significance of ECT2 in invasive breast cancer[J].J Clin Pathol,2018,71(5):442-445. [4] Zeilstra J,Joosten SP,van Andel H,et al.Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling[J].Oncogene,2014,33(5):665-670. [5]李键淇,齐洁敏.整合素α2β1及CD44v4在胃癌组织中的表达及意义[J].中国老年学杂志,2017,37(4):910-912. [6]中国抗癌协会乳腺癌专业委员会.《中国抗癌协会乳腺癌诊治指南与规范(2017年版)》修订小组成员[J].中国癌症杂志,2017,27(9):695-760. [7]Ma Y,Zhang S,Zang L,et al.Combination of shear wave elastography and Ki67 index as a novel predictive modality for the pathological response to neoadjuvant chemotherapy in patients with invasive breast cancer[J].Eur J Cancer,2016(69):86-101. [8]Kashyap T,Pramanik KK,Nath N,et al.Crosstalk between Raf-MEK-ERK and PI3K-Akt-GSK3β signaling networks promotes chemoresistance, invasion/migration and stemness via expression of CD44 variants (v4 and v6) in oral cancer[J].Oral Oncol,2018(86):234-243. [9]Spiegelberg D,Kuku G,Selvaraju R,et al.Characterization of CD44 variant expression in head and neck squamous cell carcinomas[J].Tumour Biol,2014,35(3):2053-2062. [10]Athanassiou-Papaefthymiou M,Shkeir O,Kim D,et al.Evaluation of CD44 variant expression in oral, head and neck squamous cell carcinomas using a triple approach and its clinical significance[J].Int J Immunopathol Pharmacol,2014,27(3):337-349. [11]Geng Y,Chandrasekaran S,Hsu JW,et al.Phenotypic switch in blood: effects of pro-inflammatory cytokines on breast cancer cell aggregation and adhesion[J].PLoS One,2013,8(1):54959. [12]Kozlowski J,Kozlowska A,Kocki J.Breast cancer metastasis-insight into selected molecular mechanisms of the phenomenon[J].Postepy Hig Med Dosw,2015(69):447-451. [13]Zen K,Liu DQ,Guo YL,et al.CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration[J].PLoS One,2008,3(3):e1826.

相似文献/References:

[1]刘 飞,叶 帆,杨晓文.整合素α6β1和CD44V4在卵巢上皮癌中表达及相关性分析[J].医学信息,2018,31(04):62.[doi:10.3969/j.issn.1006-1959.2018.04.020]
　LIU Fei,YE Fan,YANG Xiao-wen.Expression and Correlation of Integrin α6β1 and CD44V4 in Epithelial Ovarian Carcinoma[J].Journal of Medical Information,2018,31(11):62.[doi:10.3969/j.issn.1006-1959.2018.04.020]
[2]王 露,赵苏苏,陈思敏,等.乳腺柱状细胞病变与临床病理的关系[J].医学信息,2018,31(13):13.[doi:10.3969/j.issn.1006-1959.2018.13.004]
　WANG Lu,ZHAO Su-su,CHEN Si-min,et al.The Relationship between the Clinicopathological and Pathological Changes of Mammary Columnar Cell[J].Journal of Medical Information,2018,31(11):13.[doi:10.3969/j.issn.1006-1959.2018.13.004]

更新日期/Last Update: 2019-06-01