[1]刘 杨,王傲迪,蒙茹茹,等.氢气分子在生物医学领域研究进展[J].医学信息,2019,32(12):31-33.[doi:10.3969/j.issn.1006-1959.2019.12.011]
 LIU Yang,WANG Ao-di,MENG Ru-ru,et al.Research Progress of Hydrogen Molecules in Biomedical Field[J].Journal of Medical Information,2019,32(12):31-33.[doi:10.3969/j.issn.1006-1959.2019.12.011]
点击复制

氢气分子在生物医学领域研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年12期
页码:
31-33
栏目:
综述
出版日期:
2019-06-15

文章信息/Info

Title:
Research Progress of Hydrogen Molecules in Biomedical Field
文章编号:
1006-1959(2019)12-0031-03
作者:
刘 杨12王傲迪12蒙茹茹12马 凯12刘晓军12徐 浩13
1.西安医学院基础医学部,陕西 西安 710021; 2.西安医学院药学院,陕西 西安 710021; 3.空军军医大学生物医学工程系,陕西 西安 710032
Author(s):
LIU Yang12WANG Ao-di12MENG Ru-ru12MA Kai12LIU Xiao-jun12XU Hao13
1.Department of Basic Medicine,Xi'an Medical College,Xi'an 710021,Shaanxi,China; 2.School of Pharmacy,Xi'an Medical College,Xi'an 710021,Shaanxi,China; 3.Department of Biomedical Engineering,Air Force Military Medical University,Xi'an 710032,Shaanxi,China
关键词:
氢气分子抗炎性抗氧化
Keywords:
Key words:Hydrogen moleculeAnti-inflammatoryAnti-oxidation
分类号:
R318
DOI:
10.3969/j.issn.1006-1959.2019.12.011
文献标志码:
A
摘要:
氢气是一种无色无味的、难溶于水的、密度最小的双原子气体,具有一定的还原性。近年来,越来越多的研究表明,氢气作为一种新型的医学气体分子,有明显的抗凋亡、抗炎性和选择性抗氧化反应等作用,对多种疾病模型具有良好的防治作用,并在临床试验中取得较好的效果,但其具体的作用机制尚不完全明确。由此可见,氢气不仅不是生理性惰性气体,还是一种理想的治疗性医疗气体,要将其广泛应用于临床医学领域,还需进一步阐明并证实氢气发挥作用的确切机制,从而使其能更好地治疗人类多种相关性疾病。本文主要就氢气的医疗性应用研究进行综述。
Abstract:
Abstract:HyHdrogen is a colorless, odorless, water-insoluble, least dense diatomic gas with a certain degree of reducibility. In recent years, more and more studies have shown that hydrogen, as a new type of medical gas molecule, has obvious anti-apoptotic, anti-inflammatory and selective antioxidant effects, and has a good preventive effect on various disease models. And achieved good results in clinical trials, but its specific mechanism of action is not completely clear. It can be seen that hydrogen is not only a physiological inert gas, but also an ideal therapeutic medical gas. To be widely used in the field of clinical medicine, it is necessary to further clarify and confirm the exact mechanism of hydrogen action, so that it can be more Good treatment of a variety of related diseases in humans. This paper reviews the medical application of hydrogen.

参考文献/References:

[1]Ohsawa I,Ishikawa M,Takahashi K,et al.Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J].Nat Med,2007,13(6):688-694. [2]Ohta S,Nakao A,Ohno K.The 2011 medical molecular hydrogensymposium:An inaugural symposium of the journal medical gas research[J].Med Gas Res,2011,1(1):10. [3]Liu C,Kurokawa R,Fujino M,et al.Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes[J].Sci Rep,2014,4(1):5485-5486. [4]Meng X,Chen H,Wang G,et al.Hydrogen-rich saline attenuates chemotherapy- induced ovarian injury via regulation of oxidative stress[J].Exp Ther Med,2015,10(6):2277-2282. [5]尤杨,冯倩,夏岳,等.匹伐他汀对大鼠心肌缺血再灌注后氧化应激作用的影响[J].河北医科大学学报,2015,36(4):371-376. [6]李海英,李红,赵春慧,等.氧化应激失衡对围产儿结局及产妇产后糖代谢的影响[J].河北医科大学学报,2015,36(6):709-711. [7]Liu L,Xie K,Chen H,et al.Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation,oxidative stress and neuronal apoptosis[J].Brain Res,2014,1589(9):78-92. [8]Du Z,Jia H,Liu J,et al.Effects of three hydrogen-rich liquids on hemorrhagic shock in rats[J].J Surg Res,2015,193(1):377-382. [9]Tian Y,Guo S,Zhang Y,et al.Effects of Hydrogen-Rich Saline on Hepatectomy-Induced Postoperative Cognitive Dysfunction in Old Mice[J].Mol Neurobiol,2017,54(4):2579-2584. [10]Liu Q,Li BS,Song YJ,et al.Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice[J].Mol Med Rep,2016,13(4):3588-3596. [11]Liu GD,Zhang H,Wang L,et al.Molecular hydrogen regulates the expression of miR-9,miR-21 and miR-199 in LPS-activated retinal microglia cells[J].Int J Ophthalmol,2013,6(3):280-285. [12]Liu Y,Yang L,Tao K,et al.Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release[J].BMC Gastroenterol,2014(14):12. [13]Shigeta T,Sakamoto S,Li XK,et al.Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats[J].Transplantation,2015,99(3):500-507. [14]赵悦,马雪,解用江,等.饱和氢盐水对心肌缺血再灌注损伤老年大鼠心肌细胞线粒体损伤的影响[J].中华老年心脑血管病杂志,2016,18(12):1301-1307. [15]Noda K,Shigemura N,Tanaka Y,et al.A novel method of preserving cardiac grafts using a hydrogen-rich water bath[J].J Heater Lung Transplant,2013,32(2):241-250. [16]刘雪聪,刘福林,李志林,等.氢气对大鼠离体心肌缺血再灌注损伤的保护作用及机制[J].山东医药,2015,55(6):1-3. [17]Wang T,Zhao L,Liu M,et al.Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats[J].Toxicol Appl Pharmacol,2014,280(1):169-176. [18]Runtuwene J,Amitani H,Amitani M,et al.Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer[J].Peer J,2015(3):e859. [19]Saitoh Y,Ikeshima M,Kawasaki N,et al.Transient generation of hydrogen peroxide is responsible for carcinostatic effects of hydrogen combined with platinum nanocolloid,together with increases intracellular ROS,DNA cleavages,and proportion of G2/M-phase[J].Free Radic Res,2016,50(4):385-395. [20]李敏.富氢水对社区代谢综合征患者血脂及高密度脂蛋白功能的影响[D].泰山医学院,2013. [21]薛乾.分子氢对心肌缺血再灌注损伤保护的膜分子机制研究[D].第二军医大学,2016.

更新日期/Last Update: 2019-06-15