[1]李亮亮,王伟灵,赵 诚,等.血糖及糖化血红蛋白的检测及干扰研究进展[J].医学信息,2019,32(05):43-47.[doi:10.3969/j.issn.1006-1959.2019.05.015]
　LI Liang-liang,WANG Wei-ling,ZHAO Cheng,et al.Progress in Detection and Interference of Blood Glucose and Glycated Hemoglobin[J].Medical Information,2019,32(05):43-47.[doi:10.3969/j.issn.1006-1959.2019.05.015]
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血糖及糖化血红蛋白的检测及干扰研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年05期
页码:
43-47
栏目:
综述
出版日期:
2019-03-01

文章信息/Info

Title:
Progress in Detection and Interference of Blood Glucose and Glycated Hemoglobin
文章编号:
1006-1959（2019）05-0043-05
作者:
李亮亮; 王伟灵; 赵 诚; 尹 元
（上海中医药大学附属上海市中西医结合医院检验科，上海 200082）
Author(s):
LI Liang-liang; WANG Wei-ling; ZHAO Cheng; YIN Yuan
(Department of Clinical Laboratory,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China)
关键词:
糖尿病; 血糖; 糖化血红蛋白
Keywords:
Diabetes; Blood sugar; Glycated hemoglobin
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2019.05.015
文献标志码:
A
摘要:
2010年美国糖尿病协会将糖化血红蛋白（HbA1c）检测作为筛选和诊断糖尿病指标，其参考界值为HbA1c≥6.5%。至此，HbA1c同血糖一样正式成为糖尿病诊断检测指标。血糖及HbA1c作为杰出的糖尿病诊疗指标，其检验方法灵活多变且较易受外界多种因素影响，干扰检测结果的准确性。随着检验技术的进步，临床与糖尿病诊疗相关的生物传感器的应用逐渐广泛，本文将针对二者常见检测方法的干扰因素做一综述。
Abstract:
In 2010, the American Diabetes Association used glycosylated hemoglobin (HbA1c) as a screening and diagnostic diabetes indicator with a reference margin of HbA1c ≥ 6.5%. At this point, HbA1c has officially become a diagnostic indicator for diabetes, just like blood sugar. Blood glucose and HbA1c are excellent indicators for diagnosis and treatment of diabetes. The test methods are flexible and changeable, and are more susceptible to various external factors, which interferes with the accuracy of test results. With the advancement of testing technology, the application of biosensors related to clinical diagnosis and treatment of diabetes has become more and more extensive. This paper will review the interference factors of common detection methods.

参考文献/References:


[1]American Diabetes Association.Classification and diagnosis of diabetes[J].Diabetes Care,2017,40(Suppl 1):S11-S24.
[2]International Diabetes Federation.The IDF Diabetes Atlas8th edition[EB/OL].2017
[2018-08-30]. http://www.diabetesatlas.org/.
[3]Wang L,Gao P,Zhang M,et al.Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013[J].JAMA,2017,317(24):2515-2523.
[4]张大伟,赵刚,洪瑞金,等.人体无创血糖检测的发展与现状[J].光学仪器,2017,39(5):87-89.
[5]郭洁茹,李娟.中美权威2型糖尿病防治指南药物治疗更新透视[J].医药导报,2018,37(11):1299-1302.
[6]中国2型糖尿病防治指南(2017年版)[J].中国实用内科杂志,2018,38(4):292-344.
[7]解宏杰,邱玲,国秀芝,等.四种型号便携式血糖仪的准确度验证[J].现代检验医学杂志,2013,28(2):113-117.
[8]Lenters-Westra E,Schindhelm RK,Bilo HJ,et al.Haemoglobin A1c: historicaloverview and current concepts[J].Diabetes Res Clin Pract 2013,99(2):75-84.
[9]康建华,杨立顺,袁海生,等.变异血红蛋白和氨基甲酰血红蛋白对糖化血红蛋白测定干扰的评价[J].检验医学,2012,6(27):482-485.
[10]张力,张立平,葛才保,等.14种活血化淤类药物对生化检测指标的分析干扰[J].首都食品与医药,2015(10):109-111.
[11]周竞,颜巍,施建丰,等.维生素C对3种血糖检测方法的干扰效应分析[J].国际检验医学杂志,2017,38(10):1336-1337,1340.
[12]Sartor Z,Kesey J,Dissanaike S,et al.The Effects of IntravenousVitamin C on Point-of-Care Glucose Monitoring[J].Journal of Burn Care & Research,2015,36(1):50-56.
[13]Godwin Z,Lima K,Greenhalgh D,et al.A Retrospective Analysis of Clinical Laboratory Interferences Caused by Frequently Administered Medications in Burn Patients[J].Journal of Burn Care & Research,2016,37(1):E10-E17.
[14]邹雪梅.住院患者POCT血糖检测准确性的干扰因素分析[J].实用妇科内分泌杂志(电子版),2017,4(33):118,120.
[15]黄建荣.血液标本放置时间对生化检验结果的影响[J].内蒙古中医药,2013,25(28):167-168.
[16]Tang Z,Lee JH,Louie RF,et al.Effects of different hematocrit levels on glucose measurements with handheld meters for point-of-care testing[J].Arch Pathol Lab Med,2000,124(8):1135-1140.
[17]沈建江,符布清,赵春,等.运用CLSIEP7-A2文件评价溶血对血糖检测的影响[J].检验医学,2018,33(5):404-406.
[18]纪昕,王鑫,岳晓乐,等.3种便携式血糖检测仪的分析性能评价[J].检验医学与临床,2016,13(7):917-919.
[19]董海波.糖化血红蛋白的检测技术与临床应用进展[J].糖尿病新世界,2015,23(35):7-8.
[20]陈建标,江利爱,张玲.毛细管电泳法检测糖化血红蛋白与常见干扰因素的相关性分析[J].中国民族民间医药,2016,25(8):58-59.
[21]陈雨,胡莹莹,郝英英,等.变异血红蛋白对糖化血红蛋白检测的影响与分析[J].中华医学杂志,2014,94(6):538-441.
[22]李俊敏,杨莹,董旭婉,等.两种检测糖化血红蛋白(HbA1c)方法的比较[J].现代食品科技,2016,32(1):284-289.
[23]王彦.HbJ-Bangkok和HbD-LosAngeles对TosohG7糖化血红蛋白分析仪测定结果的干扰及处理[A]//中国生物化学与分子生物学会脂质与脂蛋白专业委员会（The Chinese Society of Lipids and Lipoproteins）.第十二届全国脂质与脂蛋白学术会议论文汇编[C].中国生物化学与分子生物学会脂质与脂蛋白专业委员会（The Chinese Society of Lipids and Lipoproteins）:中国生物化学与分子生物学会,2014.
[24]温冬梅,张秀明,索明环,等.血红蛋白变异体对糖化血红蛋白测定结果的干扰及处理[J].中华检验医学杂志,2014,37(2):123-126.
[25]徐安平,夏勇,纪玲,等.血红蛋白变异体对糖化血红蛋白不同检测系统的影响[J].中华检验医学杂志,2015,38(7):470-474.
[26]American Diabetes Association.Standards of medical care in diabetes-2013[J].Diabetes Care,2013,36(Suppl 1):S11-S66.
[27]Wen DM,Xu SN,Wang WJ,et al.Evaluation of the Interference of Hemoglobin Variant J-Bangkok on Glycated Hemoglobin (HbA1c) Measurement by Five Different Methods[J].Experimental and clinical endocrinology & diabetes,2017,125(10):655-660.
[28]杨璐,张怡婷,蒋叶.血红蛋白水平对糖化血红蛋白测定的影响[J].江苏医药,2015,24(41):2948-2950.
[29]English E,Idris I,Smith G,et al.The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis:a systematic review[J].Diabetologia,2015,58(7):1409-1421.
[30]胡耀宗,王伟佳,温冬梅,等.葡萄糖-6-磷酸脱氢酶缺乏对3种HbA1c检测系统结果的干扰评价[J].临床检验杂志,2017,35(2):98-100.
[31]郭瑛,李洪结,张育荣.免疫比浊法检测肿瘤患者糖化血红蛋白假性升高原因分析[J].国际检验医学杂志,2013,17(34):2319-2320.
[32]American Diabetes Association. Diagnosis and classification ofdiabetes mellitus[J].Diabetes Care,2014,37(Suppl 1):S81-S90.
[33]陈碧玲,谭庆玲,张惠,等.糖化血红蛋白与2 型糖尿病患者免疫功能改变的相关性分析[J].中国免疫学杂志,2014,30(10):1393-1400.
[34]刘晓丹,徐静.妊娠前空腹血糖、体质量对妊娠糖尿病患者发病的预测效果[J].海南医学,2016,27(19):3185-3187.
[35]Kwon SS,Kwon JY,Park YW,et al.HbA1c for diagnosis and prognosis of gestational diabetes mellitus[J].Diabetes Res Clin Pract,2015,110(1):38-43.
[36]董淑华.糖化血红蛋白联合空腹血糖在妊娠期糖尿病筛检中的作用分析[J].中国医药指南,2018,16(32):2-3.
[37]詹前美.糖化血红蛋白、D-二聚体、抗凝血酶Ⅲ联合检测对糖尿病微血管病变的临床应用价值[J].国际检验医学杂志,2014,11(15):332-335.
[38]Taylor R,Holmanr R.Normal weight individuals who developtype 2 diabetes: the personal fat threshold[J].Clin Sci,2015,128(7):405-410.
[39]Goodall I.HbA1c standardisation destination--global IFCCStandardisation.How, why, whereand when--a tortuous pathwayfrom kit manufacturers, via inter-laboratory lyophilized and wholeblood comparisons to designated national comparison schemes[J].Clin BiochemRev,2005,26(1):5-19.
[40]Schwartz KL,Monsur J,Hammad A,et al.Comparison of Point of Care and LaboratoryHbA1c Analysis: A MetroNet Study[J].J Am Board Family Med,2009,22(4):461-463.
[41]Pundir CS,Chawla S.Determination of glycated hemoglobin with special emphasis on biosensing methods[J].Anal Biochem,2014,444(9):47-56.
[42]Hsieh KM,Lan KC,Hu WL,et al.Glycated hemoglobin (HbA(1c)) affinity biosensors with ring-shaped interdigital electrodes on impedance measurement[J].Biosensors Bioelectronics,2013,49(5):450-456.
[43]Jain U,Chauhan N.Glycated hemoglobin detection with electrochemical sensing amplified by gold nanoparticles embedded N-doped graphene nanosheet[J].Biosensors Bioelectronic,2017,89(Suppl 1):S578-S584.

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更新日期/Last Update: 2019-03-01