[1]葛忠耀,田 寅,王 博,等.SIRT6和HIF-1α在三阴性乳腺癌中的表达及临床价值[J].医学信息,2019,32(05):95-97.[doi:10.3969/j.issn.1006-1959.2019.05.028]
　GE Zhong-yao,TIAN Yin,WANG Bo,et al.Expression and Clinical Value of SIRT6 and HIF-1α in Triple Negative Breast Cancer[J].Medical Information,2019,32(05):95-97.[doi:10.3969/j.issn.1006-1959.2019.05.028]
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SIRT6和HIF-1α在三阴性乳腺癌中的表达及临床价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年05期
页码:
95-97
栏目:
论著
出版日期:
2019-03-01

文章信息/Info

Title:
Expression and Clinical Value of SIRT6 and HIF-1α in Triple Negative Breast Cancer
文章编号:
1006-1959（2019）05-0095-03
作者:
葛忠耀; 田 寅; 王 博; 胡少军; 尹佳新; 刘应红; 徐 雷
（佳木斯大学附属第一医院肿瘤外科，黑龙江 佳木斯 154007）
Author(s):
GE Zhong-yao; TIAN Yin; WANG Bo; HU Shao-jun; YIN Jia-xin; LIU Ying-hong; XU Lei
(Department of Oncology,the First Affiliated Hospital,Jiamusi University,Jiamusi 154007,Heilongjiang,China)
关键词:
SIRT6; HIF-1α; TNBC乳腺癌; 免疫组织化学
Keywords:
SIRT6; HIF-1α; TNBC breast cancer; Immunohistochemistry
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2019.05.028
文献标志码:
A
摘要:
目的 探索SIRT6基因与缺氧诱导因子（HIF-1α）在三阴性乳腺癌（TNBC）中的表达关系，分析二者相关性及临床价值。方法 收集2017年6月~2018年12月佳木斯大学附属第一医院病理科60例TNBC乳腺癌组织及其对应60例腋窝淋巴结病理组织，并取癌旁正常组织40例。采用免疫组化法检测癌组织、转移淋巴结及癌旁组织中SIRT6、HIF-1α表达，分析二者表达与TNBC乳腺癌临床病理参数、发生发展的关系以及二者表达的相关性。结果 SIRT6在TNBC乳腺癌组织中表达阳性率（80.00%）高于癌旁组织（24.00%），差异有统计学意义（P＜0.05），其表达与TNBC乳腺癌组织分化程度，临床TNM分期、转移淋巴结有关（P＜0.05）；在TNBC乳腺癌组织、癌旁组织中HIF-1α的阳性率分别为86.67%、15.00%。且HIF-1α在TNBC乳腺癌组织与癌旁组织表达差异有统计学意义（P＜0.05）。并与TNBC乳腺癌的组织分化程度，临床TNM分期、转移淋巴结相关（P＜0.05）；在TNBC乳腺癌中SIRT6与HIF-1α的表达呈正相关（r=0.823，P＜0.05）。结论 在TNBC乳腺癌中SIRT6与HIF-1α的较高的阳性表达率可能与其发生发展及早期转移有关，检测SIRT6与HIF-1α将有助于了解TNBC乳腺癌的进展及侵袭转移情况，它们有希望为TNBC乳腺癌的早期发现、治疗及预后的评估提供新的研究思路。
Abstract:
Objective To explore the relationship between SIRT6 gene and hypoxia-inducible factor (HIF-1α) in triple negative breast cancer (TNBC), and to analyze their correlation and clinical value. Methods A total of 60 TNBC breast cancer tissues and 60 corresponding axillary lymph node tissues were collected from the Department of Pathology, the First Affiliated Hospital of Jiamusi University from June 2017 to December 2018, and 40 normal tissues adjacent to the cancer were collected. The expressions of SIRT6 and HIF-1α in cancer tissues, metastatic lymph nodes and paracancerous tissues were detected by immunohistochemistry. The relationship between the expression of SIRT6 and HIF-1α in TNBC breast cancer and the relationship between them were analyzed. Results The positive rate of SIRT6 expression in TNBC breast cancer tissues (80.00%) was higher than that in adjacent tissues (24.00%). The difference was statistically significant (P<0.05),the expression was correlated with the degree of TNBC breast cancer differentiation, clinical TNM stage and metastatic lymph nodes (P<0.05). The positive rates of HIF-1α in TNBC breast cancer tissues and adjacent tissues were 86.67% and 15.00%, respectively. The expression of HIF-1α in TNBC breast cancer tissues and adjacent tissues was statistically significant (P<0.05).It was associated with the degree of tissue differentiation, clinical TNM stage and metastatic lymph nodes of TNBC breast cancer (P<0.05). There was a positive correlation between SIRT6 and HIF-1α expression in TNBC breast cancer(r=0.823,P<0.05). Conclusion The higher positive expression rate of SIRT6 and HIF-1α in TNBC breast cancer may be related to its development and early metastasis. Detection of SIRT6 and HIF-1α will help to understand the progression and invasion and metastasis of TNBC breast cancer. I hope to provide new research ideas for the early detection, treatment and prognosis evaluation of TNBC breast cancer.

参考文献/References:


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更新日期/Last Update: 2019-03-01